Tags

Type your tag names separated by a space and hit enter

The effects of nocturnal compared with conventional hemodialysis on mineral metabolism: A randomized-controlled trial.
Hemodial Int. 2010 Apr; 14(2):174-81.HI

Abstract

Hyperphosphatemia is common among patients receiving dialysis and is associated with increased mortality. Nocturnal hemodialysis (NHD) is a long, slow dialytic modality that may improve hyperphosphatemia and disorders of mineral metabolism. We performed a randomized-controlled trial of NHD compared with conventional hemodialysis (CvHD); in this paper, we report detailed results of mineral metabolism outcomes. Prevalent patients were randomized to receive NHD 5 to 6 nights per week for 6to 10 hours per night or to continue CvHD thrice weekly for 6 months. Oral phosphate binders and vitamin D analogs were adjusted to maintain phosphate, calcium and parathyroid hormone (PTH) levels within recommended targets. Compared with CvHD patients, patients in the NHD group had a significant decrease in serum phosphate over the course of the study (0.49 mmol/L, 95% confidence interval 0.24-0.74; P=0.002) despite a significant reduction in the use of phosphate binders. Sixty-one percent of patients in the NHD group compared with 20% in the CvHD group had a decline in intact PTH (P=0.003). Nocturnal hemodialysis lowers serum phosphate, calcium-phosphate product and requirement for phosphate binders. The effects of NHD on PTH are variable. The impact of these changes on long-term cardiovascular and bone-related outcomes requires further investigation.

Authors+Show Affiliations

Department of Medicine, University of Calgary, Alberta, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20041960

Citation

Walsh, Michael, et al. "The Effects of Nocturnal Compared With Conventional Hemodialysis On Mineral Metabolism: a Randomized-controlled Trial." Hemodialysis International. International Symposium On Home Hemodialysis, vol. 14, no. 2, 2010, pp. 174-81.
Walsh M, Manns BJ, Klarenbach S, et al. The effects of nocturnal compared with conventional hemodialysis on mineral metabolism: A randomized-controlled trial. Hemodial Int. 2010;14(2):174-81.
Walsh, M., Manns, B. J., Klarenbach, S., Tonelli, M., Hemmelgarn, B., & Culleton, B. (2010). The effects of nocturnal compared with conventional hemodialysis on mineral metabolism: A randomized-controlled trial. Hemodialysis International. International Symposium On Home Hemodialysis, 14(2), 174-81. https://doi.org/10.1111/j.1542-4758.2009.00418.x
Walsh M, et al. The Effects of Nocturnal Compared With Conventional Hemodialysis On Mineral Metabolism: a Randomized-controlled Trial. Hemodial Int. 2010;14(2):174-81. PubMed PMID: 20041960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of nocturnal compared with conventional hemodialysis on mineral metabolism: A randomized-controlled trial. AU - Walsh,Michael, AU - Manns,Braden J, AU - Klarenbach,Scott, AU - Tonelli,Marcello, AU - Hemmelgarn,Brenda, AU - Culleton,Bruce, Y1 - 2009/12/22/ PY - 2010/1/1/entrez PY - 2010/1/1/pubmed PY - 2010/9/9/medline SP - 174 EP - 81 JF - Hemodialysis international. International Symposium on Home Hemodialysis JO - Hemodial Int VL - 14 IS - 2 N2 - Hyperphosphatemia is common among patients receiving dialysis and is associated with increased mortality. Nocturnal hemodialysis (NHD) is a long, slow dialytic modality that may improve hyperphosphatemia and disorders of mineral metabolism. We performed a randomized-controlled trial of NHD compared with conventional hemodialysis (CvHD); in this paper, we report detailed results of mineral metabolism outcomes. Prevalent patients were randomized to receive NHD 5 to 6 nights per week for 6to 10 hours per night or to continue CvHD thrice weekly for 6 months. Oral phosphate binders and vitamin D analogs were adjusted to maintain phosphate, calcium and parathyroid hormone (PTH) levels within recommended targets. Compared with CvHD patients, patients in the NHD group had a significant decrease in serum phosphate over the course of the study (0.49 mmol/L, 95% confidence interval 0.24-0.74; P=0.002) despite a significant reduction in the use of phosphate binders. Sixty-one percent of patients in the NHD group compared with 20% in the CvHD group had a decline in intact PTH (P=0.003). Nocturnal hemodialysis lowers serum phosphate, calcium-phosphate product and requirement for phosphate binders. The effects of NHD on PTH are variable. The impact of these changes on long-term cardiovascular and bone-related outcomes requires further investigation. SN - 1542-4758 UR - https://www.unboundmedicine.com/medline/citation/20041960/The_effects_of_nocturnal_compared_with_conventional_hemodialysis_on_mineral_metabolism:_A_randomized_controlled_trial_ L2 - https://doi.org/10.1111/j.1542-4758.2009.00418.x DB - PRIME DP - Unbound Medicine ER -