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The genetics of statin-induced myopathy.
Atherosclerosis. 2010 Jun; 210(2):337-43.A

Abstract

OBJECTIVE

Our goal was to use genetic variants to identify factors contributing to the muscular side effects of statins.

BACKGROUND

Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are usually well tolerated medications, but muscle symptoms, ranging from mild myalgia to clinically important rhabdomyolysis are an important side effect of these drugs and a leading cause of noncompliance. Recent results suggest that genetic factors increase the risk of statin-related muscle complaints. We performed a systematic review of the medical literature to determine genetic factors associated with statin myopathy.

METHODS

We identified English language articles relating statin myopathy and genetic diseases and gene variants via a PubMed search. Articles pertinent to the topic were reviewed in detail.

RESULTS/CONCLUSIONS

Our review suggests that some patients are susceptible to statin myopathy because of pre-existing subclinical inherited muscular disorders, or genetic variation in statin uptake proteins encoded by SLCO1B1 or the cytochrome P enzyme system. Variations in genes affecting pain perception and polymorphism in vascular receptors may also contribute to statin myopathy. None of the variants identified in this review suggested novel metabolic mechanisms leading to statin myopathy.

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Authors+Show Affiliations

Ghatak A
Department of Internal Medicine, University of Connecticut, Farmington, CT 06032, USA.
Faheem O
No affiliation info available
Thompson PD
No affiliation info available

MeSH

AdultAgedCytochrome P-450 Enzyme SystemFemaleGenetic VariationHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLiver-Specific Organic Anion Transporter 1MaleMiddle AgedMusclesMuscular DiseasesMuscular DystrophiesOrganic Anion TransportersRhabdomyolysis

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

20042189

Citation

Ghatak, Abhijit, et al. "The Genetics of Statin-induced Myopathy." Atherosclerosis, vol. 210, no. 2, 2010, pp. 337-43.
Ghatak A, Faheem O, Thompson PD. The genetics of statin-induced myopathy. Atherosclerosis. 2010;210(2):337-43.
Ghatak, A., Faheem, O., & Thompson, P. D. (2010). The genetics of statin-induced myopathy. Atherosclerosis, 210(2), 337-43. https://doi.org/10.1016/j.atherosclerosis.2009.11.033
Ghatak A, Faheem O, Thompson PD. The Genetics of Statin-induced Myopathy. Atherosclerosis. 2010;210(2):337-43. PubMed PMID: 20042189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The genetics of statin-induced myopathy. AU - Ghatak,Abhijit, AU - Faheem,Osman, AU - Thompson,Paul D, Y1 - 2009/11/27/ PY - 2009/10/17/received PY - 2009/11/20/revised PY - 2009/11/20/accepted PY - 2010/1/1/entrez PY - 2010/1/1/pubmed PY - 2010/12/14/medline SP - 337 EP - 43 JF - Atherosclerosis JO - Atherosclerosis VL - 210 IS - 2 N2 - OBJECTIVE: Our goal was to use genetic variants to identify factors contributing to the muscular side effects of statins. BACKGROUND: Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are usually well tolerated medications, but muscle symptoms, ranging from mild myalgia to clinically important rhabdomyolysis are an important side effect of these drugs and a leading cause of noncompliance. Recent results suggest that genetic factors increase the risk of statin-related muscle complaints. We performed a systematic review of the medical literature to determine genetic factors associated with statin myopathy. METHODS: We identified English language articles relating statin myopathy and genetic diseases and gene variants via a PubMed search. Articles pertinent to the topic were reviewed in detail. RESULTS/CONCLUSIONS: Our review suggests that some patients are susceptible to statin myopathy because of pre-existing subclinical inherited muscular disorders, or genetic variation in statin uptake proteins encoded by SLCO1B1 or the cytochrome P enzyme system. Variations in genes affecting pain perception and polymorphism in vascular receptors may also contribute to statin myopathy. None of the variants identified in this review suggested novel metabolic mechanisms leading to statin myopathy. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/20042189/The_genetics_of_statin_induced_myopathy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(09)00990-3 DB - PRIME DP - Unbound Medicine ER -