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Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats.
Phytomedicine. 2010 Jul; 17(8-9):674-8.P

Abstract

Valerian root (Valeriana officinalis) is a popular and widely available herbal supplement, primarily used to treat insomnia and anxiety. Until recently, its mechanism of action has remained unknown. Neurobiological research has begun to show that the herb, with its active valerenic acid, interacts with the GABA(A)-ergic system, a mechanism of action similar to the benzodiazepine drugs. This series of experiments sought to corroborate these findings with behavioral measures, compare them to the benzodiazepine diazepam, and to analyze the chemical composition of Valeriana officinalis. Rats were administered either ethanol (1 ml/kg), diazepam (1mg/kg), valerian root extract (3 ml/kg), valerenic acid (3mg/kg), or a solution of valerenic acid and exogenous GABA (75 microg/kg and 3.6 microg/kg, respectively) and assessed for the number of entries and time spent on the open arms of an elevated plus maze. Results showed that there was a significant reduction in anxious behavior when valerian extract or valerenic acid exposed subjects were compared to the ethanol control group. The evidence supports Valeriana officinalis as a potential alternative to the traditional anxiolytics as measured by the elevated plus maze.

Authors+Show Affiliations

Department of Psychology, Eastern Oregon University, LaGrande, OR 97850, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

20042323

Citation

Murphy, K, et al. "Valeriana Officinalis Root Extracts Have Potent Anxiolytic Effects in Laboratory Rats." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 17, no. 8-9, 2010, pp. 674-8.
Murphy K, Kubin ZJ, Shepherd JN, et al. Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. Phytomedicine. 2010;17(8-9):674-8.
Murphy, K., Kubin, Z. J., Shepherd, J. N., & Ettinger, R. H. (2010). Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 17(8-9), 674-8. https://doi.org/10.1016/j.phymed.2009.10.020
Murphy K, et al. Valeriana Officinalis Root Extracts Have Potent Anxiolytic Effects in Laboratory Rats. Phytomedicine. 2010;17(8-9):674-8. PubMed PMID: 20042323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. AU - Murphy,K, AU - Kubin,Z J, AU - Shepherd,J N, AU - Ettinger,R H, Y1 - 2009/12/29/ PY - 2009/04/07/received PY - 2009/08/24/revised PY - 2009/10/19/accepted PY - 2010/1/1/entrez PY - 2010/1/1/pubmed PY - 2010/12/14/medline SP - 674 EP - 8 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 17 IS - 8-9 N2 - Valerian root (Valeriana officinalis) is a popular and widely available herbal supplement, primarily used to treat insomnia and anxiety. Until recently, its mechanism of action has remained unknown. Neurobiological research has begun to show that the herb, with its active valerenic acid, interacts with the GABA(A)-ergic system, a mechanism of action similar to the benzodiazepine drugs. This series of experiments sought to corroborate these findings with behavioral measures, compare them to the benzodiazepine diazepam, and to analyze the chemical composition of Valeriana officinalis. Rats were administered either ethanol (1 ml/kg), diazepam (1mg/kg), valerian root extract (3 ml/kg), valerenic acid (3mg/kg), or a solution of valerenic acid and exogenous GABA (75 microg/kg and 3.6 microg/kg, respectively) and assessed for the number of entries and time spent on the open arms of an elevated plus maze. Results showed that there was a significant reduction in anxious behavior when valerian extract or valerenic acid exposed subjects were compared to the ethanol control group. The evidence supports Valeriana officinalis as a potential alternative to the traditional anxiolytics as measured by the elevated plus maze. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/20042323/Valeriana_officinalis_root_extracts_have_potent_anxiolytic_effects_in_laboratory_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(09)00290-6 DB - PRIME DP - Unbound Medicine ER -