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Genetic basis of Parkinson disease.
Neurosurg Focus. 2010 Jan; 28(1):E7.NF

Abstract

Over the past few years, considerable progress has been made in understanding the molecular mechanisms of Parkinson disease (PD). Mutations in certain genes are found to cause monogenic forms of the disorder, with autosomal dominant or autosomal recessive inheritance. These genes include alpha-synuclein, parkin, PINK1, DJ-1, LRRK2, and ATP13A2. The monogenic variants are important tools in identifying cellular pathways that shed light on the pathogenesis of this disease. Certain common genetic variants are also likely to modulate the risk of PD. International collaborative studies and meta-analyses have identified common variants as genetic susceptibility risk/protective factors for sporadic PD.

Authors+Show Affiliations

Institute for Biomedical Technology (BIOMED), Centre for Research and Technology-Thessaly (CERETETH), Larussa, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20043722

Citation

Xiromerisiou, Georgia, et al. "Genetic Basis of Parkinson Disease." Neurosurgical Focus, vol. 28, no. 1, 2010, pp. E7.
Xiromerisiou G, Dardiotis E, Tsimourtou V, et al. Genetic basis of Parkinson disease. Neurosurg Focus. 2010;28(1):E7.
Xiromerisiou, G., Dardiotis, E., Tsimourtou, V., Kountra, P. M., Paterakis, K. N., Kapsalaki, E. Z., Fountas, K. N., & Hadjigeorgiou, G. M. (2010). Genetic basis of Parkinson disease. Neurosurgical Focus, 28(1), E7. https://doi.org/10.3171/2009.10.FOCUS09220
Xiromerisiou G, et al. Genetic Basis of Parkinson Disease. Neurosurg Focus. 2010;28(1):E7. PubMed PMID: 20043722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic basis of Parkinson disease. AU - Xiromerisiou,Georgia, AU - Dardiotis,Efthimios, AU - Tsimourtou,Vaïa, AU - Kountra,Persa Maria, AU - Paterakis,Konstantinos N, AU - Kapsalaki,Eftychia Z, AU - Fountas,Kostas N, AU - Hadjigeorgiou,Georgios M, PY - 2010/1/2/entrez PY - 2010/1/2/pubmed PY - 2010/2/17/medline SP - E7 EP - E7 JF - Neurosurgical focus JO - Neurosurg Focus VL - 28 IS - 1 N2 - Over the past few years, considerable progress has been made in understanding the molecular mechanisms of Parkinson disease (PD). Mutations in certain genes are found to cause monogenic forms of the disorder, with autosomal dominant or autosomal recessive inheritance. These genes include alpha-synuclein, parkin, PINK1, DJ-1, LRRK2, and ATP13A2. The monogenic variants are important tools in identifying cellular pathways that shed light on the pathogenesis of this disease. Certain common genetic variants are also likely to modulate the risk of PD. International collaborative studies and meta-analyses have identified common variants as genetic susceptibility risk/protective factors for sporadic PD. SN - 1092-0684 UR - https://www.unboundmedicine.com/medline/citation/20043722/Genetic_basis_of_Parkinson_disease_ L2 - https://thejns.org/doi/10.3171/2009.10.FOCUS09220 DB - PRIME DP - Unbound Medicine ER -