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Association between low pulmonary function and metabolic risk factors in Korean adults: the Korean National Health and Nutrition Survey.

Abstract

Impaired lung function is a risk factor for cardiovascular events and mortality. In addition, lung function impairment is also associated with insulin resistance and type 2 diabetes mellitus. It is well known that a common mechanism, such as insulin resistance and obesity, underlies metabolic syndrome. Our aim was to evaluate the association between impaired lung function and metabolic risk factors using data from a nationwide survey of chronic obstructive pulmonary disease prevalence in Korea and the Korean National Health and Nutrition Survey in 2001. The study population included 4001 subjects (aged > or =18 years) who underwent spirometry at least twice. We analyzed the association of low pulmonary function with metabolic syndrome components using multiple linear regression and also analyzed the association of metabolic syndrome with restrictive lung disease and obstructive lung disease using multiple logistic regression adjusted for waist to height ratio, sex, age, smoking, and the other covariates. Waist girth, systolic blood pressure, and triglyceride were associated with forced vital capacity (FVC); and only triglyceride was so with forced expiratory volume in 1 second (FEV(1)), but not with FEV(1)/FVC ratio. The odds ratio of metabolic syndrome for restrictive lung disease (FVC <80%, FEV(1)/FVC >0.7) was 1.40 (95% confidence interval, 1.01-1.98), and that for obstructive lung disease (FEV(1)/FVC <0.7) was 0.93 (95% confidence interval, 0.67-1.28) after adjustment for covariates. These results indicate that low pulmonary function in the general population is associated with clustering of metabolic syndrome risk factors and, furthermore, that restrictive lung disease is also related to metabolic syndrome.

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  • Authors+Show Affiliations

    ,

    Department of Family Medicine, Health Promotion Center, Hallym University Sacred Heart Hospital, Gyeonggi 431-070, South Korea.

    , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Asian Continental Ancestry Group
    Blood Glucose
    Body Mass Index
    Health Surveys
    Humans
    Insulin Resistance
    Korea
    Logistic Models
    Lung
    Metabolic Syndrome
    Middle Aged
    Odds Ratio
    Prevalence
    Pulmonary Disease, Chronic Obstructive
    Risk Factors
    Smoking
    Spirometry
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20045536

    Citation

    Paek, Yu-Jin, et al. "Association Between Low Pulmonary Function and Metabolic Risk Factors in Korean Adults: the Korean National Health and Nutrition Survey." Metabolism: Clinical and Experimental, vol. 59, no. 9, 2010, pp. 1300-6.
    Paek YJ, Jung KS, Hwang YI, et al. Association between low pulmonary function and metabolic risk factors in Korean adults: the Korean National Health and Nutrition Survey. Metab Clin Exp. 2010;59(9):1300-6.
    Paek, Y. J., Jung, K. S., Hwang, Y. I., Lee, K. S., Lee, D. R., & Lee, J. U. (2010). Association between low pulmonary function and metabolic risk factors in Korean adults: the Korean National Health and Nutrition Survey. Metabolism: Clinical and Experimental, 59(9), pp. 1300-6. doi:10.1016/j.metabol.2009.12.005.
    Paek YJ, et al. Association Between Low Pulmonary Function and Metabolic Risk Factors in Korean Adults: the Korean National Health and Nutrition Survey. Metab Clin Exp. 2010;59(9):1300-6. PubMed PMID: 20045536.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between low pulmonary function and metabolic risk factors in Korean adults: the Korean National Health and Nutrition Survey. AU - Paek,Yu-Jin, AU - Jung,Ki-Suck, AU - Hwang,Young-Il, AU - Lee,Kang-Sook, AU - Lee,Dong Ryul, AU - Lee,Jung-Un, Y1 - 2010/01/04/ PY - 2009/02/24/received PY - 2009/11/26/revised PY - 2009/12/02/accepted PY - 2010/1/5/entrez PY - 2010/1/5/pubmed PY - 2010/9/14/medline SP - 1300 EP - 6 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 59 IS - 9 N2 - Impaired lung function is a risk factor for cardiovascular events and mortality. In addition, lung function impairment is also associated with insulin resistance and type 2 diabetes mellitus. It is well known that a common mechanism, such as insulin resistance and obesity, underlies metabolic syndrome. Our aim was to evaluate the association between impaired lung function and metabolic risk factors using data from a nationwide survey of chronic obstructive pulmonary disease prevalence in Korea and the Korean National Health and Nutrition Survey in 2001. The study population included 4001 subjects (aged > or =18 years) who underwent spirometry at least twice. We analyzed the association of low pulmonary function with metabolic syndrome components using multiple linear regression and also analyzed the association of metabolic syndrome with restrictive lung disease and obstructive lung disease using multiple logistic regression adjusted for waist to height ratio, sex, age, smoking, and the other covariates. Waist girth, systolic blood pressure, and triglyceride were associated with forced vital capacity (FVC); and only triglyceride was so with forced expiratory volume in 1 second (FEV(1)), but not with FEV(1)/FVC ratio. The odds ratio of metabolic syndrome for restrictive lung disease (FVC <80%, FEV(1)/FVC >0.7) was 1.40 (95% confidence interval, 1.01-1.98), and that for obstructive lung disease (FEV(1)/FVC <0.7) was 0.93 (95% confidence interval, 0.67-1.28) after adjustment for covariates. These results indicate that low pulmonary function in the general population is associated with clustering of metabolic syndrome risk factors and, furthermore, that restrictive lung disease is also related to metabolic syndrome. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/20045536/Association_between_low_pulmonary_function_and_metabolic_risk_factors_in_Korean_adults:_the_Korean_National_Health_and_Nutrition_Survey_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(09)00509-5 DB - PRIME DP - Unbound Medicine ER -