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Association between low pulmonary function and metabolic risk factors in Korean adults: the Korean National Health and Nutrition Survey.
Metabolism 2010; 59(9):1300-6M

Abstract

Impaired lung function is a risk factor for cardiovascular events and mortality. In addition, lung function impairment is also associated with insulin resistance and type 2 diabetes mellitus. It is well known that a common mechanism, such as insulin resistance and obesity, underlies metabolic syndrome. Our aim was to evaluate the association between impaired lung function and metabolic risk factors using data from a nationwide survey of chronic obstructive pulmonary disease prevalence in Korea and the Korean National Health and Nutrition Survey in 2001. The study population included 4001 subjects (aged > or =18 years) who underwent spirometry at least twice. We analyzed the association of low pulmonary function with metabolic syndrome components using multiple linear regression and also analyzed the association of metabolic syndrome with restrictive lung disease and obstructive lung disease using multiple logistic regression adjusted for waist to height ratio, sex, age, smoking, and the other covariates. Waist girth, systolic blood pressure, and triglyceride were associated with forced vital capacity (FVC); and only triglyceride was so with forced expiratory volume in 1 second (FEV(1)), but not with FEV(1)/FVC ratio. The odds ratio of metabolic syndrome for restrictive lung disease (FVC <80%, FEV(1)/FVC >0.7) was 1.40 (95% confidence interval, 1.01-1.98), and that for obstructive lung disease (FEV(1)/FVC <0.7) was 0.93 (95% confidence interval, 0.67-1.28) after adjustment for covariates. These results indicate that low pulmonary function in the general population is associated with clustering of metabolic syndrome risk factors and, furthermore, that restrictive lung disease is also related to metabolic syndrome.

Authors+Show Affiliations

Department of Family Medicine, Health Promotion Center, Hallym University Sacred Heart Hospital, Gyeonggi 431-070, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20045536

Citation

Paek, Yu-Jin, et al. "Association Between Low Pulmonary Function and Metabolic Risk Factors in Korean Adults: the Korean National Health and Nutrition Survey." Metabolism: Clinical and Experimental, vol. 59, no. 9, 2010, pp. 1300-6.
Paek YJ, Jung KS, Hwang YI, et al. Association between low pulmonary function and metabolic risk factors in Korean adults: the Korean National Health and Nutrition Survey. Metab Clin Exp. 2010;59(9):1300-6.
Paek, Y. J., Jung, K. S., Hwang, Y. I., Lee, K. S., Lee, D. R., & Lee, J. U. (2010). Association between low pulmonary function and metabolic risk factors in Korean adults: the Korean National Health and Nutrition Survey. Metabolism: Clinical and Experimental, 59(9), pp. 1300-6. doi:10.1016/j.metabol.2009.12.005.
Paek YJ, et al. Association Between Low Pulmonary Function and Metabolic Risk Factors in Korean Adults: the Korean National Health and Nutrition Survey. Metab Clin Exp. 2010;59(9):1300-6. PubMed PMID: 20045536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between low pulmonary function and metabolic risk factors in Korean adults: the Korean National Health and Nutrition Survey. AU - Paek,Yu-Jin, AU - Jung,Ki-Suck, AU - Hwang,Young-Il, AU - Lee,Kang-Sook, AU - Lee,Dong Ryul, AU - Lee,Jung-Un, Y1 - 2010/01/04/ PY - 2009/02/24/received PY - 2009/11/26/revised PY - 2009/12/02/accepted PY - 2010/1/5/entrez PY - 2010/1/5/pubmed PY - 2010/9/14/medline SP - 1300 EP - 6 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 59 IS - 9 N2 - Impaired lung function is a risk factor for cardiovascular events and mortality. In addition, lung function impairment is also associated with insulin resistance and type 2 diabetes mellitus. It is well known that a common mechanism, such as insulin resistance and obesity, underlies metabolic syndrome. Our aim was to evaluate the association between impaired lung function and metabolic risk factors using data from a nationwide survey of chronic obstructive pulmonary disease prevalence in Korea and the Korean National Health and Nutrition Survey in 2001. The study population included 4001 subjects (aged > or =18 years) who underwent spirometry at least twice. We analyzed the association of low pulmonary function with metabolic syndrome components using multiple linear regression and also analyzed the association of metabolic syndrome with restrictive lung disease and obstructive lung disease using multiple logistic regression adjusted for waist to height ratio, sex, age, smoking, and the other covariates. Waist girth, systolic blood pressure, and triglyceride were associated with forced vital capacity (FVC); and only triglyceride was so with forced expiratory volume in 1 second (FEV(1)), but not with FEV(1)/FVC ratio. The odds ratio of metabolic syndrome for restrictive lung disease (FVC <80%, FEV(1)/FVC >0.7) was 1.40 (95% confidence interval, 1.01-1.98), and that for obstructive lung disease (FEV(1)/FVC <0.7) was 0.93 (95% confidence interval, 0.67-1.28) after adjustment for covariates. These results indicate that low pulmonary function in the general population is associated with clustering of metabolic syndrome risk factors and, furthermore, that restrictive lung disease is also related to metabolic syndrome. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/20045536/Association_between_low_pulmonary_function_and_metabolic_risk_factors_in_Korean_adults:_the_Korean_National_Health_and_Nutrition_Survey_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(09)00509-5 DB - PRIME DP - Unbound Medicine ER -