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[Microangiopathy in chronic venous insufficiency].
Dtsch Med Wochenschr. 1991 Mar 22; 116(12):447-53.DM

Abstract

Skin in the medial malleolar region was examined in 15 patients with moderately severe venous insufficiency (9 women, 6 men; mean age 57 [35-76] years), using intravital fluorescence microscopy, transcutaneous pO2 measurement and laser Doppler flowmetry. The findings were compared with those in a healthy control group (8 women, 7 men; mean age 53 [35-73] years). The arteriolar vasoconstriction response was tested by comparing laser Doppler flowmetry readings in the recumbent and sitting positions. Transcutaneous pO2 was likewise measured in both positions. Capillary morphology and microangiodynamics were investigated before and after injection of Na-fluorescein. The microangiopathy of moderately severe venous insufficiency was characterised fluorescence microscopically by greatly dilated, elongated and winding (glomerulus-like) capillaries, and by an increase in the pericapillary leakage diameter (halo). However, the vasoconstrictive response to change in posture remained largely intact, and there was little alteration in the spontaneous rhythmic flow waves. In contrast, flow in the recumbent position was significantly increased (P less than 0.001), since laser Doppler flowmetry also measures the flow in deeper (1-6 mm), non-nutrient skin vessels. In spite of a normal capillary count, the mean transcutaneous pO2 was reduced, in keeping with the microangiopathy observed in the superficial nutrient capillaries. These pronounced morphological and dynamic changes explain the development of trophic lesions.

Authors+Show Affiliations

Departement für Innere Medizin, Universitätsspital Zürich.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

ger

PubMed ID

2004586

Citation

Leu, A J., et al. "[Microangiopathy in Chronic Venous Insufficiency]." Deutsche Medizinische Wochenschrift (1946), vol. 116, no. 12, 1991, pp. 447-53.
Leu AJ, Yanar A, Pfister G, et al. [Microangiopathy in chronic venous insufficiency]. Dtsch Med Wochenschr. 1991;116(12):447-53.
Leu, A. J., Yanar, A., Pfister, G., Geiger, M., Franzeck, U. K., & Bollinger, A. (1991). [Microangiopathy in chronic venous insufficiency]. Deutsche Medizinische Wochenschrift (1946), 116(12), 447-53.
Leu AJ, et al. [Microangiopathy in Chronic Venous Insufficiency]. Dtsch Med Wochenschr. 1991 Mar 22;116(12):447-53. PubMed PMID: 2004586.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Microangiopathy in chronic venous insufficiency]. AU - Leu,A J, AU - Yanar,A, AU - Pfister,G, AU - Geiger,M, AU - Franzeck,U K, AU - Bollinger,A, PY - 1991/3/22/pubmed PY - 1991/3/22/medline PY - 1991/3/22/entrez SP - 447 EP - 53 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch Med Wochenschr VL - 116 IS - 12 N2 - Skin in the medial malleolar region was examined in 15 patients with moderately severe venous insufficiency (9 women, 6 men; mean age 57 [35-76] years), using intravital fluorescence microscopy, transcutaneous pO2 measurement and laser Doppler flowmetry. The findings were compared with those in a healthy control group (8 women, 7 men; mean age 53 [35-73] years). The arteriolar vasoconstriction response was tested by comparing laser Doppler flowmetry readings in the recumbent and sitting positions. Transcutaneous pO2 was likewise measured in both positions. Capillary morphology and microangiodynamics were investigated before and after injection of Na-fluorescein. The microangiopathy of moderately severe venous insufficiency was characterised fluorescence microscopically by greatly dilated, elongated and winding (glomerulus-like) capillaries, and by an increase in the pericapillary leakage diameter (halo). However, the vasoconstrictive response to change in posture remained largely intact, and there was little alteration in the spontaneous rhythmic flow waves. In contrast, flow in the recumbent position was significantly increased (P less than 0.001), since laser Doppler flowmetry also measures the flow in deeper (1-6 mm), non-nutrient skin vessels. In spite of a normal capillary count, the mean transcutaneous pO2 was reduced, in keeping with the microangiopathy observed in the superficial nutrient capillaries. These pronounced morphological and dynamic changes explain the development of trophic lesions. SN - 0012-0472 UR - https://www.unboundmedicine.com/medline/citation/2004586/[Microangiopathy_in_chronic_venous_insufficiency]_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-2008-1063631 DB - PRIME DP - Unbound Medicine ER -