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Pharmacological management in children and adolescents with pervasive developmental disorder.
Aust N Z J Psychiatry. 2010 May; 44(5):410-28.AN

Abstract

OBJECTIVE

Pervasive developmental disorder (PDD) is associated with emotional and behavioural problems. There is no pharmacological cure for PDD, but some comorbidities and dysfunctional behaviours in PDD can be managed pharmacologically. The aim of the present study was to provide a better understanding of the efficacy and limitations in the currently available agents.

METHODS

Electronic literature searches were conducted from the following sources: MEDLINE, Cochrane Library, PSYARTICLES and PsycINFO. Search terms included, but were not limited to, 'autism', 'PDD', 'autism spectrum disorder' ('ASD'), and 'pharmacological management'.

RESULTS

A range of pharmacological agents are available for the management of various dysfunctional symptoms in PDD. Broadly speaking, these agents help in the management of repetitive stereotyped behaviours, anxiety, aggression/irritability/self-injurious behaviour, hyperactivity/inattention and in sleep.

CONCLUSIONS

There is a paucity of systemic, well-conducted trials on the use of pharmacological agents in the management of PDD, and more research in this area is warranted.

Authors+Show Affiliations

Department of Child and Adolescent Psychiatry, Institute of Mental Health, Singapore, Singapore. min_sung@imh.com.sgNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

20047454

Citation

Sung, Min, et al. "Pharmacological Management in Children and Adolescents With Pervasive Developmental Disorder." The Australian and New Zealand Journal of Psychiatry, vol. 44, no. 5, 2010, pp. 410-28.
Sung M, Fung DS, Cai Y, et al. Pharmacological management in children and adolescents with pervasive developmental disorder. Aust N Z J Psychiatry. 2010;44(5):410-28.
Sung, M., Fung, D. S., Cai, Y., & Ooi, Y. P. (2010). Pharmacological management in children and adolescents with pervasive developmental disorder. The Australian and New Zealand Journal of Psychiatry, 44(5), 410-28. https://doi.org/10.3109/00048670903493330
Sung M, et al. Pharmacological Management in Children and Adolescents With Pervasive Developmental Disorder. Aust N Z J Psychiatry. 2010;44(5):410-28. PubMed PMID: 20047454.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacological management in children and adolescents with pervasive developmental disorder. AU - Sung,Min, AU - Fung,Daniel S S, AU - Cai,Yiming, AU - Ooi,Yoon Phaik, PY - 2010/1/6/entrez PY - 2010/1/6/pubmed PY - 2010/9/24/medline SP - 410 EP - 28 JF - The Australian and New Zealand journal of psychiatry JO - Aust N Z J Psychiatry VL - 44 IS - 5 N2 - OBJECTIVE: Pervasive developmental disorder (PDD) is associated with emotional and behavioural problems. There is no pharmacological cure for PDD, but some comorbidities and dysfunctional behaviours in PDD can be managed pharmacologically. The aim of the present study was to provide a better understanding of the efficacy and limitations in the currently available agents. METHODS: Electronic literature searches were conducted from the following sources: MEDLINE, Cochrane Library, PSYARTICLES and PsycINFO. Search terms included, but were not limited to, 'autism', 'PDD', 'autism spectrum disorder' ('ASD'), and 'pharmacological management'. RESULTS: A range of pharmacological agents are available for the management of various dysfunctional symptoms in PDD. Broadly speaking, these agents help in the management of repetitive stereotyped behaviours, anxiety, aggression/irritability/self-injurious behaviour, hyperactivity/inattention and in sleep. CONCLUSIONS: There is a paucity of systemic, well-conducted trials on the use of pharmacological agents in the management of PDD, and more research in this area is warranted. SN - 1440-1614 UR - https://www.unboundmedicine.com/medline/citation/20047454/Pharmacological_management_in_children_and_adolescents_with_pervasive_developmental_disorder_ L2 - http://journals.sagepub.com/doi/full/10.3109/00048670903493330?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -