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Association between local traffic-generated air pollution and preeclampsia and preterm delivery in the south coast air basin of California.
Environ Health Perspect. 2009 Nov; 117(11):1773-9.EH

Abstract

BACKGROUND

Preeclampsia is a major complication of pregnancy that can lead to substantial maternal and perinatal morbidity, mortality, and preterm birth. Increasing evidence suggests that air pollution adversely affects pregnancy outcomes. Yet few studies have examined how local traffic-generated emissions affect preeclampsia in addition to preterm birth.

OBJECTIVES

We examined effects of residential exposure to local traffic-generated air pollution on preeclampsia and preterm delivery (PTD).

METHODS

We identified 81,186 singleton birth records from four hospitals (1997-2006) in Los Angeles and Orange Counties, California (USA). We used a line-source dispersion model (CALINE4) to estimate individual exposure to local traffic-generated nitrogen oxides (NO(x)) and particulate matter < 2.5 mum in aerodynamic diameter (PM(2.5)) across the entire pregnancy. We used logistic regression to estimate effects of air pollution exposures on preeclampsia, PTD (gestational age < 37 weeks), moderate PTD (MPTD; gestational age < 35 weeks), and very PTD (VPTD; gestational age < 30 weeks).

RESULTS

We observed elevated risks for preeclampsia and preterm birth from maternal exposure to local traffic-generated NO(x) and PM(2.5). The risk of preeclampsia increased 33% [odds ratio (OR) = 1.33; 95% confidence interval (CI), 1.18-1.49] and 42% (OR = 1.42; 95% CI, 1.26-1.59) for the highest NO(x) and PM(2.5) exposure quartiles, respectively. The risk of VPTD increased 128% (OR = 2.28; 95% CI, 2.15-2.42) and 81% (OR = 1.81; 95% CI, 1.71-1.92) for women in the highest NO(x) and PM(2.5) exposure quartiles, respectively.

CONCLUSION

Exposure to local traffic-generated air pollution during pregnancy increases the risk of preeclampsia and preterm birth in Southern California women. These results provide further evidence that air pollution is associated with adverse reproductive outcomes.

Authors+Show Affiliations

Program in Public Health, College of Health Sciences, University of California, Irvine, California 92697-7555, USA. junwu@uci.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20049131

Citation

Wu, Jun, et al. "Association Between Local Traffic-generated Air Pollution and Preeclampsia and Preterm Delivery in the South Coast Air Basin of California." Environmental Health Perspectives, vol. 117, no. 11, 2009, pp. 1773-9.
Wu J, Ren C, Delfino RJ, et al. Association between local traffic-generated air pollution and preeclampsia and preterm delivery in the south coast air basin of California. Environ Health Perspect. 2009;117(11):1773-9.
Wu, J., Ren, C., Delfino, R. J., Chung, J., Wilhelm, M., & Ritz, B. (2009). Association between local traffic-generated air pollution and preeclampsia and preterm delivery in the south coast air basin of California. Environmental Health Perspectives, 117(11), 1773-9. https://doi.org/10.1289/ehp.0800334
Wu J, et al. Association Between Local Traffic-generated Air Pollution and Preeclampsia and Preterm Delivery in the South Coast Air Basin of California. Environ Health Perspect. 2009;117(11):1773-9. PubMed PMID: 20049131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between local traffic-generated air pollution and preeclampsia and preterm delivery in the south coast air basin of California. AU - Wu,Jun, AU - Ren,Cizao, AU - Delfino,Ralph J, AU - Chung,Judith, AU - Wilhelm,Michelle, AU - Ritz,Beate, Y1 - 2009/06/23/ PY - 2008/10/28/received PY - 2009/06/23/accepted PY - 2010/1/6/entrez PY - 2010/1/6/pubmed PY - 2010/3/27/medline KW - air pollution KW - nitrogen oxides KW - particulate matter KW - preeclampsia KW - pregnancy outcome KW - preterm birth KW - vehicle emission SP - 1773 EP - 9 JF - Environmental health perspectives JO - Environ. Health Perspect. VL - 117 IS - 11 N2 - BACKGROUND: Preeclampsia is a major complication of pregnancy that can lead to substantial maternal and perinatal morbidity, mortality, and preterm birth. Increasing evidence suggests that air pollution adversely affects pregnancy outcomes. Yet few studies have examined how local traffic-generated emissions affect preeclampsia in addition to preterm birth. OBJECTIVES: We examined effects of residential exposure to local traffic-generated air pollution on preeclampsia and preterm delivery (PTD). METHODS: We identified 81,186 singleton birth records from four hospitals (1997-2006) in Los Angeles and Orange Counties, California (USA). We used a line-source dispersion model (CALINE4) to estimate individual exposure to local traffic-generated nitrogen oxides (NO(x)) and particulate matter < 2.5 mum in aerodynamic diameter (PM(2.5)) across the entire pregnancy. We used logistic regression to estimate effects of air pollution exposures on preeclampsia, PTD (gestational age < 37 weeks), moderate PTD (MPTD; gestational age < 35 weeks), and very PTD (VPTD; gestational age < 30 weeks). RESULTS: We observed elevated risks for preeclampsia and preterm birth from maternal exposure to local traffic-generated NO(x) and PM(2.5). The risk of preeclampsia increased 33% [odds ratio (OR) = 1.33; 95% confidence interval (CI), 1.18-1.49] and 42% (OR = 1.42; 95% CI, 1.26-1.59) for the highest NO(x) and PM(2.5) exposure quartiles, respectively. The risk of VPTD increased 128% (OR = 2.28; 95% CI, 2.15-2.42) and 81% (OR = 1.81; 95% CI, 1.71-1.92) for women in the highest NO(x) and PM(2.5) exposure quartiles, respectively. CONCLUSION: Exposure to local traffic-generated air pollution during pregnancy increases the risk of preeclampsia and preterm birth in Southern California women. These results provide further evidence that air pollution is associated with adverse reproductive outcomes. SN - 1552-9924 UR - https://www.unboundmedicine.com/medline/citation/20049131/Association_between_local_traffic_generated_air_pollution_and_preeclampsia_and_preterm_delivery_in_the_south_coast_air_basin_of_California_ L2 - https://ehp.niehs.nih.gov/doi/full/10.1289/ehp.0800334?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -