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Acceptability of a non-woven device for vaginal drug delivery of microbicides or other active agents.
AIDS Behav. 2010 Jun; 14(3):600-6.AB

Abstract

Vaginal microbicides could reduce incidence of HIV. However, the current method of delivering gel formulations (standard applicator) can result in acceptability concerns/issues. This study evaluated the concept of using a non-woven textile material (modified tampon) for vaginal drug delivery. The study was nested within a Phase I randomized safety trial of lime juice concentrations used intra-vaginally. Of 47 women completing the safety trial, 16 were interviewed about their experiences. Overall, women found the concept of non-woven materials for vaginal drug delivery acceptable for use in delivering yeast medications (13 of 16) and STI/HIV preventives (10 of 16).

Links

Publisher Full Text

Authors+Show Affiliations

Joanis CL
Behavioral and Biomedical Research Department, Family Health International, P.O. Box 13950, Research Triangle Park, NC 27709, USA. cjoanis@fhi.org
Hart CW
No affiliation info available

MeSH

Administration, IntravaginalAdultAnti-Infective AgentsCitrus aurantiifoliaDrug Delivery SystemsFemaleHIV InfectionsHIV-1HumansMenstrual Hygiene ProductsMiddle AgedPatient Acceptance of Health CareSexually Transmitted DiseasesVaginal Creams, Foams, and JelliesYoung Adult

Pub Type(s)

Clinical Trial, Phase I
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

20049522

Citation

Joanis, Carol L., and Catherine W. Hart. "Acceptability of a Non-woven Device for Vaginal Drug Delivery of Microbicides or Other Active Agents." AIDS and Behavior, vol. 14, no. 3, 2010, pp. 600-6.
Joanis CL, Hart CW. Acceptability of a non-woven device for vaginal drug delivery of microbicides or other active agents. AIDS Behav. 2010;14(3):600-6.
Joanis, C. L., & Hart, C. W. (2010). Acceptability of a non-woven device for vaginal drug delivery of microbicides or other active agents. AIDS and Behavior, 14(3), 600-6. https://doi.org/10.1007/s10461-009-9655-6
Joanis CL, Hart CW. Acceptability of a Non-woven Device for Vaginal Drug Delivery of Microbicides or Other Active Agents. AIDS Behav. 2010;14(3):600-6. PubMed PMID: 20049522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acceptability of a non-woven device for vaginal drug delivery of microbicides or other active agents. AU - Joanis,Carol L, AU - Hart,Catherine W, PY - 2010/1/6/entrez PY - 2010/1/6/pubmed PY - 2010/8/24/medline SP - 600 EP - 6 JF - AIDS and behavior JO - AIDS Behav VL - 14 IS - 3 N2 - Vaginal microbicides could reduce incidence of HIV. However, the current method of delivering gel formulations (standard applicator) can result in acceptability concerns/issues. This study evaluated the concept of using a non-woven textile material (modified tampon) for vaginal drug delivery. The study was nested within a Phase I randomized safety trial of lime juice concentrations used intra-vaginally. Of 47 women completing the safety trial, 16 were interviewed about their experiences. Overall, women found the concept of non-woven materials for vaginal drug delivery acceptable for use in delivering yeast medications (13 of 16) and STI/HIV preventives (10 of 16). SN - 1573-3254 UR - https://www.unboundmedicine.com/medline/citation/20049522/Acceptability_of_a_non_woven_device_for_vaginal_drug_delivery_of_microbicides_or_other_active_agents_ L2 - https://doi.org/10.1007/s10461-009-9655-6 DB - PRIME DP - Unbound Medicine ER -