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The PediPump: a versatile, implantable pediatric ventricular assist device--update IV.
Artif Organs. 2009 Nov; 33(11):1005-8.AO

Abstract

Cleveland Clinic's PediPump (Cleveland, OH, USA) is a ventricular assist device designed for the support of pediatric patients. The PediPump is a mixed-flow ventricular assist device with a magnetically suspended impeller measuring 10.5 mm in diameter by 64.5 mm in length. Progress and achievements for the PediPump program are considered according to the development project's three primary objectives: Basic engineering: along with size reductions, substantial design improvements have been incorporated in each design iteration including the motor, magnetic bearings, axial touch points, and heat transfer path; Anatomic modeling and device fitting studies: Techniques based on computed tomography and magnetic resonance imaging have been developed to create three-dimensional anatomic-modeling and device-fitting tools to facilitate device implantation and to assist in preoperative planning. For in vivo testing, to date, six acute (6-h duration) and nine chronic (30-day target duration) implantations have been performed in sheep; the implantation of the PediPump appears to be relatively easy with excellent hemodynamic performance and minimal hemolysis during support. Cleveland Clinic's PediPump program supported by the National Heart, Lung and Blood Institute's Pediatric Circulatory Support Program has led to the development of a pediatric ventricular assist device that has satisfactory performance in preclinical evaluation and appears to be ready to support a program of clinical testing.

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Authors+Show Affiliations

Duncan BW
The Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. duncanb@ccf.org
Fukamachi K
No affiliation info available
Noble LD
No affiliation info available
Dudzinski DT
No affiliation info available
Flick CR
No affiliation info available
Fumoto H
No affiliation info available
Shiose A
No affiliation info available
Arakawa Y
No affiliation info available
Takaseya T
No affiliation info available
Casas F
No affiliation info available
Smith WA
No affiliation info available

MeSH

AnimalsHeart Valve Prosthesis ImplantationHeart-Assist DevicesHemodynamicsHemolysisHumansInfantPediatricsProsthesis DesignSheep

Pub Type(s)

Evaluation Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20050296

Citation

Duncan, Brian W., et al. "The PediPump: a Versatile, Implantable Pediatric Ventricular Assist Device--update IV." Artificial Organs, vol. 33, no. 11, 2009, pp. 1005-8.
Duncan BW, Fukamachi K, Noble LD, et al. The PediPump: a versatile, implantable pediatric ventricular assist device--update IV. Artif Organs. 2009;33(11):1005-8.
Duncan, B. W., Fukamachi, K., Noble, L. D., Dudzinski, D. T., Flick, C. R., Fumoto, H., Shiose, A., Arakawa, Y., Takaseya, T., Casas, F., & Smith, W. A. (2009). The PediPump: a versatile, implantable pediatric ventricular assist device--update IV. Artificial Organs, 33(11), 1005-8.
Duncan BW, et al. The PediPump: a Versatile, Implantable Pediatric Ventricular Assist Device--update IV. Artif Organs. 2009;33(11):1005-8. PubMed PMID: 20050296.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The PediPump: a versatile, implantable pediatric ventricular assist device--update IV. AU - Duncan,Brian W, AU - Fukamachi,Kiyotaka, AU - Noble,Lawrence D,Jr AU - Dudzinski,David T, AU - Flick,Christine R, AU - Fumoto,Hideyuki, AU - Shiose,Akira, AU - Arakawa,Yoko, AU - Takaseya,Tohru, AU - Casas,Fernando, AU - Smith,William A, PY - 2010/1/6/entrez PY - 2010/1/6/pubmed PY - 2010/3/5/medline SP - 1005 EP - 8 JF - Artificial organs JO - Artif Organs VL - 33 IS - 11 N2 - Cleveland Clinic's PediPump (Cleveland, OH, USA) is a ventricular assist device designed for the support of pediatric patients. The PediPump is a mixed-flow ventricular assist device with a magnetically suspended impeller measuring 10.5 mm in diameter by 64.5 mm in length. Progress and achievements for the PediPump program are considered according to the development project's three primary objectives: Basic engineering: along with size reductions, substantial design improvements have been incorporated in each design iteration including the motor, magnetic bearings, axial touch points, and heat transfer path; Anatomic modeling and device fitting studies: Techniques based on computed tomography and magnetic resonance imaging have been developed to create three-dimensional anatomic-modeling and device-fitting tools to facilitate device implantation and to assist in preoperative planning. For in vivo testing, to date, six acute (6-h duration) and nine chronic (30-day target duration) implantations have been performed in sheep; the implantation of the PediPump appears to be relatively easy with excellent hemodynamic performance and minimal hemolysis during support. Cleveland Clinic's PediPump program supported by the National Heart, Lung and Blood Institute's Pediatric Circulatory Support Program has led to the development of a pediatric ventricular assist device that has satisfactory performance in preclinical evaluation and appears to be ready to support a program of clinical testing. SN - 1525-1594 UR - https://www.unboundmedicine.com/medline/citation/20050296/The_PediPump:_a_versatile_implantable_pediatric_ventricular_assist_device__update_IV_ L2 - https://doi.org/10.1111/j.1525-1594.2009.00946.x DB - PRIME DP - Unbound Medicine ER -