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A multicenter study of the association of serum uric acid, serum creatinine, and diuretic use in hypertensive patients.
Int J Cardiol. 2011 May 05; 148(3):325-30.IJ

Abstract

BACKGROUND

Individuals with hypertension and hyperuricemia have an increased risk of coronary artery disease and cerebral vascular disease as compared to patients with normal uric acid levels. Our aim is to determine the prevalence of hyperuricemia in hypertensive patients in Taiwan, and whether serum uric acid (SUA) is associated with changes in renal function in patients with hypertension.

METHODS

We studied 2145 hypertensive patients receiving medical treatment, assessed the prevalence of hyperuricemia, and determined the independent risk factors for SUA. Simple correlation and multiple regression analyses were applied to identify the independent risk factors for SUA increase. Logistic regression analysis was used to estimate the association between 4 quartiles of SUA level and correspondent serum creatinine (SCr) concentrations.

RESULTS

Hypertensive subjects had a high prevalence of hyperuricemia (men, 35%; women, 43%). SUA was significantly associated with the independent risk factors of SCr, diuretic usage, and diabetes (inversely related) in both genders, whereas β-blocker usage and body mass index were only associated in men. Multiple logistic regression models showed that in the non-diuretic user group the highest SUA quartile entailed >4 times greater risk for SCr elevation than the lowest. In the diuretic user group, a >2 times greater risk was noted.

CONCLUSIONS

Hyperuricemia hypertensive subjects demonstrated a corresponding elevation of SUA and SCr irrespective of diuretic use. Elevation of SUA, in addition to SCr, may represent a progression of renal function impairment.

Authors+Show Affiliations

Department of Internal Medicine, Chung Shan Medical University Hospital, School of Medicine, Chung Shan Medical University, 110, Section 1, Chien Kuo North Road, Taichung, 402, Taiwan. lcs@csmu.edu.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20053470

Citation

Lin, Chung-Sheng, et al. "A Multicenter Study of the Association of Serum Uric Acid, Serum Creatinine, and Diuretic Use in Hypertensive Patients." International Journal of Cardiology, vol. 148, no. 3, 2011, pp. 325-30.
Lin CS, Hung YJ, Chen GY, et al. A multicenter study of the association of serum uric acid, serum creatinine, and diuretic use in hypertensive patients. Int J Cardiol. 2011;148(3):325-30.
Lin, C. S., Hung, Y. J., Chen, G. Y., Tzeng, T. F., Lee, D. Y., Chen, C. Y., Huang, W. P., & Huang, C. H. (2011). A multicenter study of the association of serum uric acid, serum creatinine, and diuretic use in hypertensive patients. International Journal of Cardiology, 148(3), 325-30. https://doi.org/10.1016/j.ijcard.2009.11.024
Lin CS, et al. A Multicenter Study of the Association of Serum Uric Acid, Serum Creatinine, and Diuretic Use in Hypertensive Patients. Int J Cardiol. 2011 May 5;148(3):325-30. PubMed PMID: 20053470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A multicenter study of the association of serum uric acid, serum creatinine, and diuretic use in hypertensive patients. AU - Lin,Chung-Sheng, AU - Hung,Yi-Jen, AU - Chen,Gau-Yang, AU - Tzeng,Thing-Fong, AU - Lee,Du-Yi, AU - Chen,Cheng-Yun, AU - Huang,Wen-Pin, AU - Huang,Chin-Hsung, Y1 - 2010/01/06/ PY - 2009/04/12/received PY - 2009/09/13/revised PY - 2009/11/29/accepted PY - 2010/1/8/entrez PY - 2010/1/8/pubmed PY - 2012/3/7/medline SP - 325 EP - 30 JF - International journal of cardiology JO - Int J Cardiol VL - 148 IS - 3 N2 - BACKGROUND: Individuals with hypertension and hyperuricemia have an increased risk of coronary artery disease and cerebral vascular disease as compared to patients with normal uric acid levels. Our aim is to determine the prevalence of hyperuricemia in hypertensive patients in Taiwan, and whether serum uric acid (SUA) is associated with changes in renal function in patients with hypertension. METHODS: We studied 2145 hypertensive patients receiving medical treatment, assessed the prevalence of hyperuricemia, and determined the independent risk factors for SUA. Simple correlation and multiple regression analyses were applied to identify the independent risk factors for SUA increase. Logistic regression analysis was used to estimate the association between 4 quartiles of SUA level and correspondent serum creatinine (SCr) concentrations. RESULTS: Hypertensive subjects had a high prevalence of hyperuricemia (men, 35%; women, 43%). SUA was significantly associated with the independent risk factors of SCr, diuretic usage, and diabetes (inversely related) in both genders, whereas β-blocker usage and body mass index were only associated in men. Multiple logistic regression models showed that in the non-diuretic user group the highest SUA quartile entailed >4 times greater risk for SCr elevation than the lowest. In the diuretic user group, a >2 times greater risk was noted. CONCLUSIONS: Hyperuricemia hypertensive subjects demonstrated a corresponding elevation of SUA and SCr irrespective of diuretic use. Elevation of SUA, in addition to SCr, may represent a progression of renal function impairment. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/20053470/A_multicenter_study_of_the_association_of_serum_uric_acid_serum_creatinine_and_diuretic_use_in_hypertensive_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(09)01621-0 DB - PRIME DP - Unbound Medicine ER -