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Maternal multiple micronutrient supplementation has limited impact on micronutrient status of Bangladeshi infants compared with standard iron and folic acid supplementation.
J Nutr. 2010 Mar; 140(3):618-24.JN

Abstract

Knowledge about the impact of maternal food and micronutrient supplementation on infant micronutrient status is limited. We examined the effect of maternal food and micronutrient supplementation on infant micronutrient status in the Maternal and Infant Nutrition Interventions in Matlab Trial. Pregnant women (n = 4436) were randomized to Early or Usual promotion of enrollment in a food supplementation program. In addition, they were randomly allocated to 1 of the following 3 types of daily micronutrient supplements provided from wk 14 of gestation to 3 mo postpartum: 1) folic acid and 30 mg iron (Fe30Fol); 2) folic acid and 60 mg iron; or 3) a multiple micronutrient including folic acid and 30 mg iron (MMS). At 6 mo, infant blood samples (n = 1066) were collected and analyzed for hemoglobin and plasma ferritin, zinc, retinol, vitamin B-12, and folate. The vitamin B-12 concentration differed between the micronutrient supplementation groups (P = 0.049). The prevalence of vitamin B-12 deficiency was lower in the MMS group (26.1%) than in the Fe30Fol group (36.5%) (P = 0.003). The prevalence of zinc deficiency was lower in the Usual food supplementation group (54.1%) than in the Early group (60.2%) (P = 0.046). There were no other differential effects according to food or micronutrient supplementation groups. We conclude that maternal multiple micronutrient supplementation may have a beneficial effect on vitamin B-12 status in infancy.

Authors+Show Affiliations

International Maternal and Child Health, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. hanna.eneroth@kbh.uu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20053938

Citation

Eneroth, Hanna, et al. "Maternal Multiple Micronutrient Supplementation Has Limited Impact On Micronutrient Status of Bangladeshi Infants Compared With Standard Iron and Folic Acid Supplementation." The Journal of Nutrition, vol. 140, no. 3, 2010, pp. 618-24.
Eneroth H, El Arifeen S, Persson LA, et al. Maternal multiple micronutrient supplementation has limited impact on micronutrient status of Bangladeshi infants compared with standard iron and folic acid supplementation. J Nutr. 2010;140(3):618-24.
Eneroth, H., El Arifeen, S., Persson, L. A., Lönnerdal, B., Hossain, M. B., Stephensen, C. B., & Ekström, E. C. (2010). Maternal multiple micronutrient supplementation has limited impact on micronutrient status of Bangladeshi infants compared with standard iron and folic acid supplementation. The Journal of Nutrition, 140(3), 618-24. https://doi.org/10.3945/jn.109.111740
Eneroth H, et al. Maternal Multiple Micronutrient Supplementation Has Limited Impact On Micronutrient Status of Bangladeshi Infants Compared With Standard Iron and Folic Acid Supplementation. J Nutr. 2010;140(3):618-24. PubMed PMID: 20053938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal multiple micronutrient supplementation has limited impact on micronutrient status of Bangladeshi infants compared with standard iron and folic acid supplementation. AU - Eneroth,Hanna, AU - El Arifeen,Shams, AU - Persson,Lars-Ake, AU - Lönnerdal,Bo, AU - Hossain,Mohammad Bakhtiar, AU - Stephensen,Charles B, AU - Ekström,Eva-Charlotte, Y1 - 2010/01/06/ PY - 2010/1/8/entrez PY - 2010/1/8/pubmed PY - 2010/3/26/medline SP - 618 EP - 24 JF - The Journal of nutrition JO - J. Nutr. VL - 140 IS - 3 N2 - Knowledge about the impact of maternal food and micronutrient supplementation on infant micronutrient status is limited. We examined the effect of maternal food and micronutrient supplementation on infant micronutrient status in the Maternal and Infant Nutrition Interventions in Matlab Trial. Pregnant women (n = 4436) were randomized to Early or Usual promotion of enrollment in a food supplementation program. In addition, they were randomly allocated to 1 of the following 3 types of daily micronutrient supplements provided from wk 14 of gestation to 3 mo postpartum: 1) folic acid and 30 mg iron (Fe30Fol); 2) folic acid and 60 mg iron; or 3) a multiple micronutrient including folic acid and 30 mg iron (MMS). At 6 mo, infant blood samples (n = 1066) were collected and analyzed for hemoglobin and plasma ferritin, zinc, retinol, vitamin B-12, and folate. The vitamin B-12 concentration differed between the micronutrient supplementation groups (P = 0.049). The prevalence of vitamin B-12 deficiency was lower in the MMS group (26.1%) than in the Fe30Fol group (36.5%) (P = 0.003). The prevalence of zinc deficiency was lower in the Usual food supplementation group (54.1%) than in the Early group (60.2%) (P = 0.046). There were no other differential effects according to food or micronutrient supplementation groups. We conclude that maternal multiple micronutrient supplementation may have a beneficial effect on vitamin B-12 status in infancy. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/20053938/Maternal_multiple_micronutrient_supplementation_has_limited_impact_on_micronutrient_status_of_Bangladeshi_infants_compared_with_standard_iron_and_folic_acid_supplementation_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.109.111740 DB - PRIME DP - Unbound Medicine ER -