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Effect of long-term valproate monotherapy on bone mineral density in adults with epilepsy.
J Neurol Sci. 2010 Mar 15; 290(1-2):131-4.JN

Abstract

BACKGROUND

We evaluated the cross-sectional relationship of duration and dosage of valproate monotherapy on bone mineral density (BMD) in adult patients with epilepsy.

METHODS

The BMD at lumbar level (L2-L4) was measured in consecutive adult epileptic patients receiving long-term (> or =2 years) valproate monotherapy by dual energy X-ray absorptiometry (DXA). Blood samples were collected for total serum calcium, phosphorus, magnesium, 25-hydroxyvitamin D(3) and parathormone. Osteopenia and osteoporosis were defined according to the World Health Organization operational BMD definition. Cross-sectional associations were evaluated using Spearman's correlation coefficient.

RESULTS

A total of 41 patients were studied (mean age 32.3+/-8.2 years, 12 men, mean duration of valproate monotherapy 10.6+/-7.4 years). Osteopenia was present in 24% of subjects, while no case of osteoporosis was documented. Duration and dosage of valproate monotherapy did not correlate with BMD. No association was documented between duration or dosage of valproate monotherapy and biochemical parameters.

CONCLUSIONS

Duration of valproate monotherapy does not correlate with decreased BMD in adult patients with epilepsy. No case of osteoporosis was identified in patients treated with valproate for a mean period of more than ten years. These findings indicate that bone metabolism may not be affected by valproate monotherapy.

Authors+Show Affiliations

Department of Neurology, University of Athens, Eginition Hospital, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

20056251

Citation

Triantafyllou, Nikos, et al. "Effect of Long-term Valproate Monotherapy On Bone Mineral Density in Adults With Epilepsy." Journal of the Neurological Sciences, vol. 290, no. 1-2, 2010, pp. 131-4.
Triantafyllou N, Lambrinoudaki I, Armeni E, et al. Effect of long-term valproate monotherapy on bone mineral density in adults with epilepsy. J Neurol Sci. 2010;290(1-2):131-4.
Triantafyllou, N., Lambrinoudaki, I., Armeni, E., Evangelopoulos, E. M., Boufidou, F., Antoniou, A., & Tsivgoulis, G. (2010). Effect of long-term valproate monotherapy on bone mineral density in adults with epilepsy. Journal of the Neurological Sciences, 290(1-2), 131-4. https://doi.org/10.1016/j.jns.2009.12.015
Triantafyllou N, et al. Effect of Long-term Valproate Monotherapy On Bone Mineral Density in Adults With Epilepsy. J Neurol Sci. 2010 Mar 15;290(1-2):131-4. PubMed PMID: 20056251.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of long-term valproate monotherapy on bone mineral density in adults with epilepsy. AU - Triantafyllou,Nikos, AU - Lambrinoudaki,Irini, AU - Armeni,Elena, AU - Evangelopoulos,Eleftheria-Maria, AU - Boufidou,Fotini, AU - Antoniou,Aris, AU - Tsivgoulis,Georgios, Y1 - 2010/01/06/ PY - 2009/09/10/received PY - 2009/11/05/revised PY - 2009/12/16/accepted PY - 2010/1/9/entrez PY - 2010/1/9/pubmed PY - 2010/5/14/medline SP - 131 EP - 4 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 290 IS - 1-2 N2 - BACKGROUND: We evaluated the cross-sectional relationship of duration and dosage of valproate monotherapy on bone mineral density (BMD) in adult patients with epilepsy. METHODS: The BMD at lumbar level (L2-L4) was measured in consecutive adult epileptic patients receiving long-term (> or =2 years) valproate monotherapy by dual energy X-ray absorptiometry (DXA). Blood samples were collected for total serum calcium, phosphorus, magnesium, 25-hydroxyvitamin D(3) and parathormone. Osteopenia and osteoporosis were defined according to the World Health Organization operational BMD definition. Cross-sectional associations were evaluated using Spearman's correlation coefficient. RESULTS: A total of 41 patients were studied (mean age 32.3+/-8.2 years, 12 men, mean duration of valproate monotherapy 10.6+/-7.4 years). Osteopenia was present in 24% of subjects, while no case of osteoporosis was documented. Duration and dosage of valproate monotherapy did not correlate with BMD. No association was documented between duration or dosage of valproate monotherapy and biochemical parameters. CONCLUSIONS: Duration of valproate monotherapy does not correlate with decreased BMD in adult patients with epilepsy. No case of osteoporosis was identified in patients treated with valproate for a mean period of more than ten years. These findings indicate that bone metabolism may not be affected by valproate monotherapy. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/20056251/Effect_of_long_term_valproate_monotherapy_on_bone_mineral_density_in_adults_with_epilepsy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(09)01006-5 DB - PRIME DP - Unbound Medicine ER -