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Effect of family history on the risk of varicose veins is affected by differential misclassification.
J Clin Epidemiol. 2010 Jun; 63(6):686-90.JC

Abstract

OBJECTIVE

We assessed differential misclassification in self-reported family history of varicose veins by comparing consistency of subject's own varicose vein status and the consistency of information on varicose veins in family members.

STUDY DESIGN AND SETTING

A population-based cohort study of 4,903 middle-aged residents of the city of Tampere, Finland. A questionnaire was used at entry and at the end of the 5-year follow-up.

RESULTS

The estimated prevalence of positive family history of varicose veins varied depending on subject's own varicose veins from odds ratio (OR) 0.14 (95% confidence interval [CI]=0.01-0.58), in those with varicose veins reported in the first but not the second survey to OR 6.0 (95% CI=2.0-47.8), in those with varicose veins reported in the second survey but not in the first. The incidence of varicose veins varied from 0.4 (95% CI=0.1-1.4) to 4.1 (95% CI=2.1-7.1) (per 100 person-years) depending how the proband memorized the family history.

CONCLUSION

Results on the effect of family history on varicose veins are subject to bias, which reduces the credibility of the reports proposing a strong hereditary component of varicose veins.

Authors+Show Affiliations

Tampere School of Public Health, University of Tampere, Finland. tiina.jukkola@uta.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20056383

Citation

Ahti, Tiina M., et al. "Effect of Family History On the Risk of Varicose Veins Is Affected By Differential Misclassification." Journal of Clinical Epidemiology, vol. 63, no. 6, 2010, pp. 686-90.
Ahti TM, Mäkivaara LA, Luukkaala T, et al. Effect of family history on the risk of varicose veins is affected by differential misclassification. J Clin Epidemiol. 2010;63(6):686-90.
Ahti, T. M., Mäkivaara, L. A., Luukkaala, T., Hakama, M., & Laurikka, J. O. (2010). Effect of family history on the risk of varicose veins is affected by differential misclassification. Journal of Clinical Epidemiology, 63(6), 686-90. https://doi.org/10.1016/j.jclinepi.2009.10.003
Ahti TM, et al. Effect of Family History On the Risk of Varicose Veins Is Affected By Differential Misclassification. J Clin Epidemiol. 2010;63(6):686-90. PubMed PMID: 20056383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of family history on the risk of varicose veins is affected by differential misclassification. AU - Ahti,Tiina M, AU - Mäkivaara,Liisa A, AU - Luukkaala,Tiina, AU - Hakama,Matti, AU - Laurikka,Jari O, Y1 - 2010/01/08/ PY - 2009/02/09/received PY - 2009/10/08/revised PY - 2009/10/12/accepted PY - 2010/1/9/entrez PY - 2010/1/9/pubmed PY - 2010/9/16/medline SP - 686 EP - 90 JF - Journal of clinical epidemiology JO - J Clin Epidemiol VL - 63 IS - 6 N2 - OBJECTIVE: We assessed differential misclassification in self-reported family history of varicose veins by comparing consistency of subject's own varicose vein status and the consistency of information on varicose veins in family members. STUDY DESIGN AND SETTING: A population-based cohort study of 4,903 middle-aged residents of the city of Tampere, Finland. A questionnaire was used at entry and at the end of the 5-year follow-up. RESULTS: The estimated prevalence of positive family history of varicose veins varied depending on subject's own varicose veins from odds ratio (OR) 0.14 (95% confidence interval [CI]=0.01-0.58), in those with varicose veins reported in the first but not the second survey to OR 6.0 (95% CI=2.0-47.8), in those with varicose veins reported in the second survey but not in the first. The incidence of varicose veins varied from 0.4 (95% CI=0.1-1.4) to 4.1 (95% CI=2.1-7.1) (per 100 person-years) depending how the proband memorized the family history. CONCLUSION: Results on the effect of family history on varicose veins are subject to bias, which reduces the credibility of the reports proposing a strong hereditary component of varicose veins. SN - 1878-5921 UR - https://www.unboundmedicine.com/medline/citation/20056383/Effect_of_family_history_on_the_risk_of_varicose_veins_is_affected_by_differential_misclassification_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0895-4356(09)00330-8 DB - PRIME DP - Unbound Medicine ER -