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Nutrient-based dietary patterns and laryngeal cancer: evidence from an exploratory factor analysis.

Abstract

BACKGROUND

The issue of diet and laryngeal cancer has been rarely addressed considering the potential role of dietary patterns.

METHODS

We examined this association using data from a case-control study carried out between 1992 and 2000. Cases were 460 histologically confirmed incident laryngeal cancers hospitalized in two Italian areas. Controls were 1,088 subjects hospitalized for acute nonneoplastic diseases unrelated to tobacco or alcohol consumption. Dietary habits were investigated through a 78-item food frequency questionnaire. A posteriori dietary patterns were identified through principal component factor analysis carried out on a selected set of 28 major nutrients. The internal reproducibility, robustness, and reliability of the identified patterns were evaluated. Odds ratios (OR) of laryngeal cancer and 95% confidence intervals (95% CI) were estimated using unconditional multiple logistic regression models on quartiles of factor scores.

RESULTS

We identified five major dietary patterns named "animal products," "starch-rich," "vitamins and fiber," "vegetable unsaturated fatty acids," and "animal unsaturated fatty acids." The vitamins and fiber dietary pattern was inversely associated with laryngeal cancer (OR, 0.35; 95% CI, 0.24-0.52 for the highest versus the lowest score quartile), whereas the animal products (OR, 2.34; 95% CI, 1.59-3.45) and the animal unsaturated fatty acids (OR, 2.07; 95% CI, 1.42-3.01) patterns were directly associated with it. There was no significant association between the vegetable unsaturated fatty acids and the starch-rich patterns and laryngeal cancer risk.

CONCLUSION

These findings suggest that diets rich in animal products and animal fats are directly related, and those rich in fruit and vegetables inversely related, to laryngeal cancer risk.

Authors+Show Affiliations

Facoltà di Medicina e Chirurgia, Istituto di Statistica Medica e Biometria Giulio A. Maccacaro, Università degli Studi di Milano, via Venezian, 1, 20133 Milan, Italy. valeria.edefonti@unimi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20056619

Citation

Edefonti, Valeria, et al. "Nutrient-based Dietary Patterns and Laryngeal Cancer: Evidence From an Exploratory Factor Analysis." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 19, no. 1, 2010, pp. 18-27.
Edefonti V, Bravi F, Garavello W, et al. Nutrient-based dietary patterns and laryngeal cancer: evidence from an exploratory factor analysis. Cancer Epidemiol Biomarkers Prev. 2010;19(1):18-27.
Edefonti, V., Bravi, F., Garavello, W., La Vecchia, C., Parpinel, M., Franceschi, S., ... Decarli, A. (2010). Nutrient-based dietary patterns and laryngeal cancer: evidence from an exploratory factor analysis. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 19(1), pp. 18-27. doi:10.1158/1055-9965.EPI-09-0900.
Edefonti V, et al. Nutrient-based Dietary Patterns and Laryngeal Cancer: Evidence From an Exploratory Factor Analysis. Cancer Epidemiol Biomarkers Prev. 2010;19(1):18-27. PubMed PMID: 20056619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutrient-based dietary patterns and laryngeal cancer: evidence from an exploratory factor analysis. AU - Edefonti,Valeria, AU - Bravi,Francesca, AU - Garavello,Werner, AU - La Vecchia,Carlo, AU - Parpinel,Maria, AU - Franceschi,Silvia, AU - Dal Maso,Luigino, AU - Bosetti,Cristina, AU - Boffetta,Paolo, AU - Ferraroni,Monica, AU - Decarli,Adriano, PY - 2010/1/9/entrez PY - 2010/1/9/pubmed PY - 2010/3/10/medline SP - 18 EP - 27 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 19 IS - 1 N2 - BACKGROUND: The issue of diet and laryngeal cancer has been rarely addressed considering the potential role of dietary patterns. METHODS: We examined this association using data from a case-control study carried out between 1992 and 2000. Cases were 460 histologically confirmed incident laryngeal cancers hospitalized in two Italian areas. Controls were 1,088 subjects hospitalized for acute nonneoplastic diseases unrelated to tobacco or alcohol consumption. Dietary habits were investigated through a 78-item food frequency questionnaire. A posteriori dietary patterns were identified through principal component factor analysis carried out on a selected set of 28 major nutrients. The internal reproducibility, robustness, and reliability of the identified patterns were evaluated. Odds ratios (OR) of laryngeal cancer and 95% confidence intervals (95% CI) were estimated using unconditional multiple logistic regression models on quartiles of factor scores. RESULTS: We identified five major dietary patterns named "animal products," "starch-rich," "vitamins and fiber," "vegetable unsaturated fatty acids," and "animal unsaturated fatty acids." The vitamins and fiber dietary pattern was inversely associated with laryngeal cancer (OR, 0.35; 95% CI, 0.24-0.52 for the highest versus the lowest score quartile), whereas the animal products (OR, 2.34; 95% CI, 1.59-3.45) and the animal unsaturated fatty acids (OR, 2.07; 95% CI, 1.42-3.01) patterns were directly associated with it. There was no significant association between the vegetable unsaturated fatty acids and the starch-rich patterns and laryngeal cancer risk. CONCLUSION: These findings suggest that diets rich in animal products and animal fats are directly related, and those rich in fruit and vegetables inversely related, to laryngeal cancer risk. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/20056619/Nutrient_based_dietary_patterns_and_laryngeal_cancer:_evidence_from_an_exploratory_factor_analysis_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=20056619 DB - PRIME DP - Unbound Medicine ER -