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INPH and Parkinson disease: differentiation by levodopa response.
Nat Rev Neurol. 2010 01; 6(1):52-6.NR

Abstract

Differentiating between Parkinson disease (PD) and idiopathic normal pressure hydrocephalus (INPH) can be challenging for the practicing clinician. Patients with undiagnosed PD but with incidental ventriculomegaly run the risk of being subjected to unnecessary shunt surgery. Taking a family history of PD and establishing the presence of motor symptoms (tremor, rigidity, bradykinesia) and nonmotor symptoms could help to differentiate between the two disorders. For patients with parkinsonian features, a dopamine challenge test to exclude the possibility of idiopathic PD might be beneficial. In this article, we highlight the difficulty of accurately differentiating INPH from PD as illustrated by three clinical cases of patients referred for shunt surgery.

Authors+Show Affiliations

Department of Neurology, University of Florida College of Medicine, Shands Hospital, Movement Disorders Center, McKnight Brain Institute, 100 S. Newell Drive, Gainesville, FL 32610, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20057498

Citation

Morishita, Takashi, et al. "INPH and Parkinson Disease: Differentiation By Levodopa Response." Nature Reviews. Neurology, vol. 6, no. 1, 2010, pp. 52-6.
Morishita T, Foote KD, Okun MS. INPH and Parkinson disease: differentiation by levodopa response. Nat Rev Neurol. 2010;6(1):52-6.
Morishita, T., Foote, K. D., & Okun, M. S. (2010). INPH and Parkinson disease: differentiation by levodopa response. Nature Reviews. Neurology, 6(1), 52-6. https://doi.org/10.1038/nrneurol.2009.195
Morishita T, Foote KD, Okun MS. INPH and Parkinson Disease: Differentiation By Levodopa Response. Nat Rev Neurol. 2010;6(1):52-6. PubMed PMID: 20057498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - INPH and Parkinson disease: differentiation by levodopa response. AU - Morishita,Takashi, AU - Foote,Kelly D, AU - Okun,Michael S, PY - 2010/1/9/entrez PY - 2010/1/9/pubmed PY - 2010/3/10/medline SP - 52 EP - 6 JF - Nature reviews. Neurology JO - Nat Rev Neurol VL - 6 IS - 1 N2 - Differentiating between Parkinson disease (PD) and idiopathic normal pressure hydrocephalus (INPH) can be challenging for the practicing clinician. Patients with undiagnosed PD but with incidental ventriculomegaly run the risk of being subjected to unnecessary shunt surgery. Taking a family history of PD and establishing the presence of motor symptoms (tremor, rigidity, bradykinesia) and nonmotor symptoms could help to differentiate between the two disorders. For patients with parkinsonian features, a dopamine challenge test to exclude the possibility of idiopathic PD might be beneficial. In this article, we highlight the difficulty of accurately differentiating INPH from PD as illustrated by three clinical cases of patients referred for shunt surgery. SN - 1759-4766 UR - https://www.unboundmedicine.com/medline/citation/20057498/INPH_and_Parkinson_disease:_differentiation_by_levodopa_response_ L2 - https://doi.org/10.1038/nrneurol.2009.195 DB - PRIME DP - Unbound Medicine ER -