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Comparison between preloading with 10 ml/kg and 20 ml/kg of Ringer's lactate in preventing hypotension during spinal anaesthesia for caesarean section.
Med J Malaysia 2009; 64(2):114-7MJ

Abstract

This prospective, randomized, study was designed to compare the effect of two different preloading volumes of Ringer's lactate for prevention of maternal hypotension induced by spinal anaesthesia for Caesarean section. Eighty ASA I or II obstetric patients were randomized to two groups. Group 1 (n = 40) received 20 ml/kg of Ringer's lactate and Group 2 (n = 40) 10 ml/kg of Ringer's lactate over 20 minutes before spinal anaesthesia. The lowest mean arterial pressure (MAP) for both groups were recorded at 15 minutes after giving spinal anaesthesia, This difference in the drop of MAP from base-line at 15 minutes (mean decrease of 12.5 mmHg from baseline), between preloading with 10 ml/kg and 20 ml/kg of Ringer's was statistically significant. Twelve patients from Group 1 required bolus doses of ephedrine and 15% of these needed additional crystalloid whereas two patients from Group 2 needed ephedrine boluses and 22% of these required additional crystalloid. The difference in frequency of requirement for treatment of hypotension was not statistically significant. There were five patients in Group 1 and six patients in Group 2 who experienced nausea and vomiting, the frequency of occurrence did not show any statistically significant difference between the two groups. In conclusion, for prevention of hypotension during spinal anaesthesia for Caesarean section, infusing 20 ml/kg or 10 ml/kg of Ringer's Lactate gave similar results and we do not recommend the use of a larger volume of crystalloid for preloading before spinal anaesthesia.

Authors+Show Affiliations

Department of Anaesthesiology and Intensive Care, Hospital Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

20058569

Citation

Muzlifah, K B., and Y C. Choy. "Comparison Between Preloading With 10 Ml/kg and 20 Ml/kg of Ringer's Lactate in Preventing Hypotension During Spinal Anaesthesia for Caesarean Section." The Medical Journal of Malaysia, vol. 64, no. 2, 2009, pp. 114-7.
Muzlifah KB, Choy YC. Comparison between preloading with 10 ml/kg and 20 ml/kg of Ringer's lactate in preventing hypotension during spinal anaesthesia for caesarean section. Med J Malaysia. 2009;64(2):114-7.
Muzlifah, K. B., & Choy, Y. C. (2009). Comparison between preloading with 10 ml/kg and 20 ml/kg of Ringer's lactate in preventing hypotension during spinal anaesthesia for caesarean section. The Medical Journal of Malaysia, 64(2), pp. 114-7.
Muzlifah KB, Choy YC. Comparison Between Preloading With 10 Ml/kg and 20 Ml/kg of Ringer's Lactate in Preventing Hypotension During Spinal Anaesthesia for Caesarean Section. Med J Malaysia. 2009;64(2):114-7. PubMed PMID: 20058569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison between preloading with 10 ml/kg and 20 ml/kg of Ringer's lactate in preventing hypotension during spinal anaesthesia for caesarean section. AU - Muzlifah,K B, AU - Choy,Y C, PY - 2010/1/12/entrez PY - 2010/1/12/pubmed PY - 2010/2/19/medline SP - 114 EP - 7 JF - The Medical journal of Malaysia JO - Med. J. Malaysia VL - 64 IS - 2 N2 - This prospective, randomized, study was designed to compare the effect of two different preloading volumes of Ringer's lactate for prevention of maternal hypotension induced by spinal anaesthesia for Caesarean section. Eighty ASA I or II obstetric patients were randomized to two groups. Group 1 (n = 40) received 20 ml/kg of Ringer's lactate and Group 2 (n = 40) 10 ml/kg of Ringer's lactate over 20 minutes before spinal anaesthesia. The lowest mean arterial pressure (MAP) for both groups were recorded at 15 minutes after giving spinal anaesthesia, This difference in the drop of MAP from base-line at 15 minutes (mean decrease of 12.5 mmHg from baseline), between preloading with 10 ml/kg and 20 ml/kg of Ringer's was statistically significant. Twelve patients from Group 1 required bolus doses of ephedrine and 15% of these needed additional crystalloid whereas two patients from Group 2 needed ephedrine boluses and 22% of these required additional crystalloid. The difference in frequency of requirement for treatment of hypotension was not statistically significant. There were five patients in Group 1 and six patients in Group 2 who experienced nausea and vomiting, the frequency of occurrence did not show any statistically significant difference between the two groups. In conclusion, for prevention of hypotension during spinal anaesthesia for Caesarean section, infusing 20 ml/kg or 10 ml/kg of Ringer's Lactate gave similar results and we do not recommend the use of a larger volume of crystalloid for preloading before spinal anaesthesia. SN - 0300-5283 UR - https://www.unboundmedicine.com/medline/citation/20058569/Comparison_between_preloading_with_10_ml/kg_and_20_ml/kg_of_Ringer's_lactate_in_preventing_hypotension_during_spinal_anaesthesia_for_caesarean_section_ L2 - http://www.e-mjm.org/2009/v64n2/Ringers_Lactate_Preventing_Hypotension.pdf DB - PRIME DP - Unbound Medicine ER -