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[Effects of ShenSongYangXin on action potential and some current channels in isolated rabbit pulmonary vein cardiomyocytes].
Zhonghua Yi Xue Za Zhi. 2009 Aug 11; 89(30):2142-6.ZY

Abstract

OBJECTIVE

To investigate the effects of ShenSongYangXin on action potential and some current channels in isolated rabbit pulmonary vein cardiomyocytes and to elucidate its possible mechanism of curing atrial fibrillation.

METHODS

Action potentials as well as L-type calcium channel current (I(Ca-L)), transient outward potassium current (I(K1)) and inward rectifier potassium current (I(To)) were recorded using whole cell patch-clamp technique.

RESULTS

ShenSongYangXin prolonged the action potential duration (APD) significantly, APD90 was enlarged from (187 +/- 49) ms to (286 +/- 76) ms at the concentration of 5 mg/ml and to (312 +/- 82) ms at the concentration of 10 mg/dl respectively (P < 0.05). It also depressed the current of I(Ca-L), I(K1) and Iro in a concentration-dependent manner.

CONCLUSION

ShenSongYangXin can be used to treat atrial fibrillation through its actions on multiple current channels.

Authors+Show Affiliations

Shi L
Heart Center, Beijing Chao-Yang Hospital, Capital University of Medical Sciences, Beijing 100020, China.
Yang XC
No affiliation info available
Liu XL
No affiliation info available
Zong M
No affiliation info available
Wu YL
No affiliation info available

MeSH

Action PotentialsAnimalsAtrial FibrillationCalcium Channels, L-TypeCells, CulturedDrugs, Chinese HerbalFemaleMaleMyocytes, CardiacPatch-Clamp TechniquesPotassium Channels, Inwardly RectifyingPulmonary VeinsRabbits

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

20058622

Citation

Shi, Liang, et al. "[Effects of ShenSongYangXin On Action Potential and some Current Channels in Isolated Rabbit Pulmonary Vein Cardiomyocytes]." Zhonghua Yi Xue Za Zhi, vol. 89, no. 30, 2009, pp. 2142-6.
Shi L, Yang XC, Liu XL, et al. [Effects of ShenSongYangXin on action potential and some current channels in isolated rabbit pulmonary vein cardiomyocytes]. Zhonghua Yi Xue Za Zhi. 2009;89(30):2142-6.
Shi, L., Yang, X. C., Liu, X. L., Zong, M., & Wu, Y. L. (2009). [Effects of ShenSongYangXin on action potential and some current channels in isolated rabbit pulmonary vein cardiomyocytes]. Zhonghua Yi Xue Za Zhi, 89(30), 2142-6.
Shi L, et al. [Effects of ShenSongYangXin On Action Potential and some Current Channels in Isolated Rabbit Pulmonary Vein Cardiomyocytes]. Zhonghua Yi Xue Za Zhi. 2009 Aug 11;89(30):2142-6. PubMed PMID: 20058622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of ShenSongYangXin on action potential and some current channels in isolated rabbit pulmonary vein cardiomyocytes]. AU - Shi,Liang, AU - Yang,Xin-Chun, AU - Liu,Xiu-Lan, AU - Zong,Min, AU - Wu,Yi-Ling, PY - 2010/1/12/entrez PY - 2010/1/12/pubmed PY - 2010/5/25/medline SP - 2142 EP - 6 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 89 IS - 30 N2 - OBJECTIVE: To investigate the effects of ShenSongYangXin on action potential and some current channels in isolated rabbit pulmonary vein cardiomyocytes and to elucidate its possible mechanism of curing atrial fibrillation. METHODS: Action potentials as well as L-type calcium channel current (I(Ca-L)), transient outward potassium current (I(K1)) and inward rectifier potassium current (I(To)) were recorded using whole cell patch-clamp technique. RESULTS: ShenSongYangXin prolonged the action potential duration (APD) significantly, APD90 was enlarged from (187 +/- 49) ms to (286 +/- 76) ms at the concentration of 5 mg/ml and to (312 +/- 82) ms at the concentration of 10 mg/dl respectively (P < 0.05). It also depressed the current of I(Ca-L), I(K1) and Iro in a concentration-dependent manner. CONCLUSION: ShenSongYangXin can be used to treat atrial fibrillation through its actions on multiple current channels. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/20058622/[Effects_of_ShenSongYangXin_on_action_potential_and_some_current_channels_in_isolated_rabbit_pulmonary_vein_cardiomyocytes]_ DB - PRIME DP - Unbound Medicine ER -