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Long-term effects of three commercial cranberry products on the antioxidative status in rats: a pilot study.
J Agric Food Chem. 2010 Feb 10; 58(3):1672-8.JA

Abstract

Cranberry (Vaccinium macrocarpon Ait. Ericaceae) fruits and juice are widely used for their antiadherence and antioxidative properties. Little is known however about their effects on clinical chemistry markers after long-term consumption. This study was conducted to evaluate the effect of three commercial cranberry products, NUTRICRAN90S, HI-PAC 4.0, and PACRAN on the antioxidative status of rodents, divided into three experimental groups. The products were given as dietary admixtures (1500 mg of product/kg of stock feed) for 14 weeks to male Wistar rats (Groups 2-4) and a control Group 1 which received only stock feed. There were no significant cranberry treatment-related effects on oxidative stress parameters, catalase, glutathione peroxidase, glutathione reductase, glutathione transferase, superoxide dismutase, total antioxidant capacity, thiobarbituric acid reactive substances, advanced oxidation protein products, total SH-groups, or any other measured clinical chemistry markers. Hematological parameters, body weight, and food consumption were also unaffected by intake of cranberries. Only liver glutathione reductase activity and glutathione levels were significantly lower in Group 4 than in Group 1. Plasma alkaline phosphatase alone was significantly decreased in Group 2. No gross pathology, effects on organ weights, or histopathology were observed. No genotoxicity was found, and total cytochrome P450 level in liver was unaffected in all groups. The levels of hippuric acid and several phenolic acids were significantly increased in plasma and urine in Groups 2-4. The concentration of anthocyanins was under the detection threshold. The dietary addition of cranberry powders for 14 weeks was well tolerated, but it did not improve the antioxidative status in rats.

Authors+Show Affiliations

Department of Medical Chemistry and Biochemistry, Palacky University, Hnevotinska 3, 775 15 Olomouc, Czech Republic.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20058864

Citation

Palikova, Irena, et al. "Long-term Effects of Three Commercial Cranberry Products On the Antioxidative Status in Rats: a Pilot Study." Journal of Agricultural and Food Chemistry, vol. 58, no. 3, 2010, pp. 1672-8.
Palikova I, Vostalova J, Zdarilova A, et al. Long-term effects of three commercial cranberry products on the antioxidative status in rats: a pilot study. J Agric Food Chem. 2010;58(3):1672-8.
Palikova, I., Vostalova, J., Zdarilova, A., Svobodova, A., Kosina, P., Vecera, R., Stejskal, D., Proskova, J., Hrbac, J., Bednar, P., Maier, V., Cernochova, D., Simanek, V., & Ulrichova, J. (2010). Long-term effects of three commercial cranberry products on the antioxidative status in rats: a pilot study. Journal of Agricultural and Food Chemistry, 58(3), 1672-8. https://doi.org/10.1021/jf903710y
Palikova I, et al. Long-term Effects of Three Commercial Cranberry Products On the Antioxidative Status in Rats: a Pilot Study. J Agric Food Chem. 2010 Feb 10;58(3):1672-8. PubMed PMID: 20058864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term effects of three commercial cranberry products on the antioxidative status in rats: a pilot study. AU - Palikova,Irena, AU - Vostalova,Jitka, AU - Zdarilova,Adela, AU - Svobodova,Alena, AU - Kosina,Pavel, AU - Vecera,Rostislav, AU - Stejskal,David, AU - Proskova,Jitka, AU - Hrbac,Jan, AU - Bednar,Petr, AU - Maier,Vitezslav, AU - Cernochova,Drahomira, AU - Simanek,Vilim, AU - Ulrichova,Jitka, PY - 2010/1/12/entrez PY - 2010/1/12/pubmed PY - 2010/4/20/medline SP - 1672 EP - 8 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 58 IS - 3 N2 - Cranberry (Vaccinium macrocarpon Ait. Ericaceae) fruits and juice are widely used for their antiadherence and antioxidative properties. Little is known however about their effects on clinical chemistry markers after long-term consumption. This study was conducted to evaluate the effect of three commercial cranberry products, NUTRICRAN90S, HI-PAC 4.0, and PACRAN on the antioxidative status of rodents, divided into three experimental groups. The products were given as dietary admixtures (1500 mg of product/kg of stock feed) for 14 weeks to male Wistar rats (Groups 2-4) and a control Group 1 which received only stock feed. There were no significant cranberry treatment-related effects on oxidative stress parameters, catalase, glutathione peroxidase, glutathione reductase, glutathione transferase, superoxide dismutase, total antioxidant capacity, thiobarbituric acid reactive substances, advanced oxidation protein products, total SH-groups, or any other measured clinical chemistry markers. Hematological parameters, body weight, and food consumption were also unaffected by intake of cranberries. Only liver glutathione reductase activity and glutathione levels were significantly lower in Group 4 than in Group 1. Plasma alkaline phosphatase alone was significantly decreased in Group 2. No gross pathology, effects on organ weights, or histopathology were observed. No genotoxicity was found, and total cytochrome P450 level in liver was unaffected in all groups. The levels of hippuric acid and several phenolic acids were significantly increased in plasma and urine in Groups 2-4. The concentration of anthocyanins was under the detection threshold. The dietary addition of cranberry powders for 14 weeks was well tolerated, but it did not improve the antioxidative status in rats. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/20058864/Long_term_effects_of_three_commercial_cranberry_products_on_the_antioxidative_status_in_rats:_a_pilot_study_ L2 - https://doi.org/10.1021/jf903710y DB - PRIME DP - Unbound Medicine ER -