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Adipokines and inflammatory mediators after initial periodontal treatment in patients with type 2 diabetes and chronic periodontitis.
J Periodontol. 2010 Jan; 81(1):24-33.JP

Abstract

BACKGROUND

This study was performed to evaluate the effects of initial periodontal treatment on clinical periodontal measurements, glycemic control, and systemic inflammatory mediator levels in patients with type 2 diabetes and chronic periodontitis.

METHODS

Thirteen well-controlled (glycated hemoglobin [HbA1c] <7%) and 12 poorly controlled (HbA1c > or =7%) patients with type 2 diabetes and chronic periodontitis and 15 systemically healthy patients with chronic periodontitis were enrolled. Blood samples were collected at baseline from all patients and 1 and 3 months after the initial periodontal treatment from patients with diabetes. Serum levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, C-reactive protein (CRP), soluble intercellular adhesion molecule-1, adiponectin, and leptin were analyzed by enzyme-linked immunosorbent assay.

RESULTS

The study groups showed similar improvements in clinical periodontal variables at all evaluation times (P <0.05). HbA1c levels in the poorly controlled group with diabetes decreased significantly at 3 months after completion of the initial periodontal treatment (P <0.05), whereas no significant changes were evident in the well-controlled group. There were insignificant decreases in TNF-alpha and CRP levels (P >0.05). IL-6 levels decreased in well-controlled patients with diabetes and in the systemically healthy group (P <0.05). Adiponectin levels increased in the systemically healthy group (P <0.05). Leptin levels increased at 1 month in well-controlled patients with diabetes (P <0.05).

CONCLUSIONS

Within the limits of this study, patients with type 2 diabetes and chronic periodontitis exhibited similar clinical periodontal improvements as their systemically healthy counterparts. Initial periodontal treatment appeared to improve glycemic control in poorly controlled patients with diabetes. Decreases in levels of IL-6, TNF-alpha, CRP, and leptin and an increase in adiponectin levels after periodontal therapy may be a function of glycemic control in patients with type 2 diabetes.

Authors+Show Affiliations

Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20059414

Citation

Kardeşler, Levent, et al. "Adipokines and Inflammatory Mediators After Initial Periodontal Treatment in Patients With Type 2 Diabetes and Chronic Periodontitis." Journal of Periodontology, vol. 81, no. 1, 2010, pp. 24-33.
Kardeşler L, Buduneli N, Cetinkalp S, et al. Adipokines and inflammatory mediators after initial periodontal treatment in patients with type 2 diabetes and chronic periodontitis. J Periodontol. 2010;81(1):24-33.
Kardeşler, L., Buduneli, N., Cetinkalp, S., & Kinane, D. F. (2010). Adipokines and inflammatory mediators after initial periodontal treatment in patients with type 2 diabetes and chronic periodontitis. Journal of Periodontology, 81(1), 24-33. https://doi.org/10.1902/jop.2009.090267
Kardeşler L, et al. Adipokines and Inflammatory Mediators After Initial Periodontal Treatment in Patients With Type 2 Diabetes and Chronic Periodontitis. J Periodontol. 2010;81(1):24-33. PubMed PMID: 20059414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adipokines and inflammatory mediators after initial periodontal treatment in patients with type 2 diabetes and chronic periodontitis. AU - Kardeşler,Levent, AU - Buduneli,Nurcan, AU - Cetinkalp,Sevki, AU - Kinane,Denis F, PY - 2010/1/12/entrez PY - 2010/1/12/pubmed PY - 2010/4/15/medline SP - 24 EP - 33 JF - Journal of periodontology JO - J. Periodontol. VL - 81 IS - 1 N2 - BACKGROUND: This study was performed to evaluate the effects of initial periodontal treatment on clinical periodontal measurements, glycemic control, and systemic inflammatory mediator levels in patients with type 2 diabetes and chronic periodontitis. METHODS: Thirteen well-controlled (glycated hemoglobin [HbA1c] <7%) and 12 poorly controlled (HbA1c > or =7%) patients with type 2 diabetes and chronic periodontitis and 15 systemically healthy patients with chronic periodontitis were enrolled. Blood samples were collected at baseline from all patients and 1 and 3 months after the initial periodontal treatment from patients with diabetes. Serum levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, C-reactive protein (CRP), soluble intercellular adhesion molecule-1, adiponectin, and leptin were analyzed by enzyme-linked immunosorbent assay. RESULTS: The study groups showed similar improvements in clinical periodontal variables at all evaluation times (P <0.05). HbA1c levels in the poorly controlled group with diabetes decreased significantly at 3 months after completion of the initial periodontal treatment (P <0.05), whereas no significant changes were evident in the well-controlled group. There were insignificant decreases in TNF-alpha and CRP levels (P >0.05). IL-6 levels decreased in well-controlled patients with diabetes and in the systemically healthy group (P <0.05). Adiponectin levels increased in the systemically healthy group (P <0.05). Leptin levels increased at 1 month in well-controlled patients with diabetes (P <0.05). CONCLUSIONS: Within the limits of this study, patients with type 2 diabetes and chronic periodontitis exhibited similar clinical periodontal improvements as their systemically healthy counterparts. Initial periodontal treatment appeared to improve glycemic control in poorly controlled patients with diabetes. Decreases in levels of IL-6, TNF-alpha, CRP, and leptin and an increase in adiponectin levels after periodontal therapy may be a function of glycemic control in patients with type 2 diabetes. SN - 1943-3670 UR - https://www.unboundmedicine.com/medline/citation/20059414/Adipokines_and_inflammatory_mediators_after_initial_periodontal_treatment_in_patients_with_type_2_diabetes_and_chronic_periodontitis_ L2 - https://doi.org/10.1902/jop.2009.090267 DB - PRIME DP - Unbound Medicine ER -