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High-intensity sweeteners and energy balance.

Abstract

Recent epidemiological evidence points to a link between a variety of negative health outcomes (e.g. metabolic syndrome, diabetes and cardiovascular disease) and the consumption of both calorically sweetened beverages and beverages sweetened with high-intensity, non-caloric sweeteners. Research on the possibility that non-nutritive sweeteners promote food intake, body weight gain, and metabolic disorders has been hindered by the lack of a physiologically-relevant model that describes the mechanistic basis for these outcomes. We have suggested that based on Pavlovian conditioning principles, consumption of non-nutritive sweeteners could result in sweet tastes no longer serving as consistent predictors of nutritive postingestive consequences. This dissociation between the sweet taste cues and the caloric consequences could lead to a decrease in the ability of sweet tastes to evoke physiological responses that serve to regulate energy balance. Using a rodent model, we have found that intake of foods or fluids containing non-nutritive sweeteners was accompanied by increased food intake, body weight gain, accumulation of body fat, and weaker caloric compensation, compared to consumption of foods and fluids containing glucose. Our research also provided evidence consistent with the hypothesis that these effects of consuming saccharin may be associated with a decrement in the ability of sweet taste to evoke thermic responses, and perhaps other physiological, cephalic phase, reflexes that are thought to help maintain energy balance.

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  • Authors+Show Affiliations

    ,

    Department of Psychological Sciences, Purdue University, 703 Third Street, West Lafayette, IN 47907, United States. swithers@purdue.edu

    ,

    Source

    Physiology & behavior 100:1 2010 Apr 26 pg 55-62

    MeSH

    Adiposity
    Animals
    Body Weight
    Conditioning, Classical
    Disease Models, Animal
    Eating
    Energy Metabolism
    Food Preferences
    Humans
    Metabolic Diseases
    Obesity
    Sweetening Agents

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Review

    Language

    eng

    PubMed ID

    20060008

    Citation

    Swithers, Susan E., et al. "High-intensity Sweeteners and Energy Balance." Physiology & Behavior, vol. 100, no. 1, 2010, pp. 55-62.
    Swithers SE, Martin AA, Davidson TL. High-intensity sweeteners and energy balance. Physiol Behav. 2010;100(1):55-62.
    Swithers, S. E., Martin, A. A., & Davidson, T. L. (2010). High-intensity sweeteners and energy balance. Physiology & Behavior, 100(1), pp. 55-62. doi:10.1016/j.physbeh.2009.12.021.
    Swithers SE, Martin AA, Davidson TL. High-intensity Sweeteners and Energy Balance. Physiol Behav. 2010 Apr 26;100(1):55-62. PubMed PMID: 20060008.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - High-intensity sweeteners and energy balance. AU - Swithers,Susan E, AU - Martin,Ashley A, AU - Davidson,Terry L, Y1 - 2010/01/06/ PY - 2009/10/21/received PY - 2009/12/08/revised PY - 2009/12/21/accepted PY - 2010/1/12/entrez PY - 2010/1/12/pubmed PY - 2010/7/2/medline SP - 55 EP - 62 JF - Physiology & behavior JO - Physiol. Behav. VL - 100 IS - 1 N2 - Recent epidemiological evidence points to a link between a variety of negative health outcomes (e.g. metabolic syndrome, diabetes and cardiovascular disease) and the consumption of both calorically sweetened beverages and beverages sweetened with high-intensity, non-caloric sweeteners. Research on the possibility that non-nutritive sweeteners promote food intake, body weight gain, and metabolic disorders has been hindered by the lack of a physiologically-relevant model that describes the mechanistic basis for these outcomes. We have suggested that based on Pavlovian conditioning principles, consumption of non-nutritive sweeteners could result in sweet tastes no longer serving as consistent predictors of nutritive postingestive consequences. This dissociation between the sweet taste cues and the caloric consequences could lead to a decrease in the ability of sweet tastes to evoke physiological responses that serve to regulate energy balance. Using a rodent model, we have found that intake of foods or fluids containing non-nutritive sweeteners was accompanied by increased food intake, body weight gain, accumulation of body fat, and weaker caloric compensation, compared to consumption of foods and fluids containing glucose. Our research also provided evidence consistent with the hypothesis that these effects of consuming saccharin may be associated with a decrement in the ability of sweet taste to evoke thermic responses, and perhaps other physiological, cephalic phase, reflexes that are thought to help maintain energy balance. SN - 1873-507X UR - https://www.unboundmedicine.com/medline/citation/20060008/High_intensity_sweeteners_and_energy_balance_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9384(09)00408-9 DB - PRIME DP - Unbound Medicine ER -