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Cardiovascular risk factors in hemodialysis and peritoneal dialysis patients.
Saudi J Kidney Dis Transpl. 2010 Jan; 21(1):59-62.SJ

Abstract

Cardiovascular diseases are a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). The aim of our investigation was the evaluation of an extensive cardiovascular profile in hemodialysis (HD) and peritoneal dialysis (PD) patients. We studied 74 patients with ESRD (38 males, 36 females), maintained either on chronic HD (n= 50) or chronic PD (n= 24) and age and sex matched 20 healthy subjects as controls. The lipid profile, homocysteine (Hcy) and C reactive protein (CRP) were measured. When compared to a healthy population, HD patients displayed a marked atherogenic profile, as attested by increased levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), apolipoprotein A (Apo A), CRP, Hcy and lower concentrations of high-density lipoprotein-cholesterol (HDL-C), Apo B, albumin (ALB). A significant difference was noted concerning the rates of Apo B, HDL-C, TC, ALB and Hcy. Same biological disorders that those found at HD patients were noted in these PD patients. One also noted lower concentration in Apo A. there were a significant difference with the reference group concerning the rates of albumin, Apo A, HDL-Cl and Hcy. When compared to PD patients, HD patients had significantly decreased concentration of LDL-C. The peculiar metabolic changes observed in the present study confirm the marked tendency of patients with impaired renal function for developing cardiovascular diseases, irrespectively of the type of dialysis. We suggest including uremia-related risk factors in the panel for evaluation of cardiovascular risk in dialysis patients.

Authors+Show Affiliations

Department of Internal Medicine A and Laboratory of Kidney Pathology 02, Charles Nicolle Hospital, Boulevard 9 Avril, 1006 Tunis, Tunisia. imedhelal@voila.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20061694

Citation

Helal, Imed, et al. "Cardiovascular Risk Factors in Hemodialysis and Peritoneal Dialysis Patients." Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia, vol. 21, no. 1, 2010, pp. 59-62.
Helal I, Smaoui W, Hamida FB, et al. Cardiovascular risk factors in hemodialysis and peritoneal dialysis patients. Saudi J Kidney Dis Transpl. 2010;21(1):59-62.
Helal, I., Smaoui, W., Hamida, F. B., Ouniss, M., Aderrahim, E., Hedri, H., Elyounsi, F., Maiz, H. B., Abdallah, T. B., & Kheder, A. (2010). Cardiovascular risk factors in hemodialysis and peritoneal dialysis patients. Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 21(1), 59-62.
Helal I, et al. Cardiovascular Risk Factors in Hemodialysis and Peritoneal Dialysis Patients. Saudi J Kidney Dis Transpl. 2010;21(1):59-62. PubMed PMID: 20061694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular risk factors in hemodialysis and peritoneal dialysis patients. AU - Helal,Imed, AU - Smaoui,Wided, AU - Hamida,Fethi Ben, AU - Ouniss,Monder, AU - Aderrahim,Ezzeddine, AU - Hedri,Hafedh, AU - Elyounsi,Fethi, AU - Maiz,Hedi Ben, AU - Abdallah,Taieb Ben, AU - Kheder,Adel, PY - 2010/1/12/entrez PY - 2010/1/12/pubmed PY - 2010/3/12/medline SP - 59 EP - 62 JF - Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia JO - Saudi J Kidney Dis Transpl VL - 21 IS - 1 N2 - Cardiovascular diseases are a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). The aim of our investigation was the evaluation of an extensive cardiovascular profile in hemodialysis (HD) and peritoneal dialysis (PD) patients. We studied 74 patients with ESRD (38 males, 36 females), maintained either on chronic HD (n= 50) or chronic PD (n= 24) and age and sex matched 20 healthy subjects as controls. The lipid profile, homocysteine (Hcy) and C reactive protein (CRP) were measured. When compared to a healthy population, HD patients displayed a marked atherogenic profile, as attested by increased levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), apolipoprotein A (Apo A), CRP, Hcy and lower concentrations of high-density lipoprotein-cholesterol (HDL-C), Apo B, albumin (ALB). A significant difference was noted concerning the rates of Apo B, HDL-C, TC, ALB and Hcy. Same biological disorders that those found at HD patients were noted in these PD patients. One also noted lower concentration in Apo A. there were a significant difference with the reference group concerning the rates of albumin, Apo A, HDL-Cl and Hcy. When compared to PD patients, HD patients had significantly decreased concentration of LDL-C. The peculiar metabolic changes observed in the present study confirm the marked tendency of patients with impaired renal function for developing cardiovascular diseases, irrespectively of the type of dialysis. We suggest including uremia-related risk factors in the panel for evaluation of cardiovascular risk in dialysis patients. SN - 1319-2442 UR - https://www.unboundmedicine.com/medline/citation/20061694/Cardiovascular_risk_factors_in_hemodialysis_and_peritoneal_dialysis_patients_ L2 - http://www.sjkdt.org/article.asp?issn=1319-2442;year=2010;volume=21;issue=1;spage=59;epage=62;aulast=Helal DB - PRIME DP - Unbound Medicine ER -