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Is the action spectrum for the UV-induced production of previtamin D3 in human skin correct?
Photochem Photobiol Sci. 2010 Jan; 9(1):11-7.PP

Abstract

The universally recognised action spectrum for the UV-induced conversion of 7-dehydrocholesterol to previtamin D(3) in human skin was published in 1982, and indicates a maximum at about 297 nm with essentially no production above 315 nm. This work represents a milestone in research on vitamin D, but limitations in the original data should be recognised. Various findings have arisen in recent years which cast doubts on the accuracy of the action spectrum and its application for spectral weighting in calculations of effective UV doses. In conclusion, the construction of an entirely new computational model to predict previtamin D levels is recommended.

Authors+Show Affiliations

Biomedical Sciences, University of Edinburgh Medical School, Teviot Place, Edinburgh, EH8 9AG, UK. M.Norval@ed.ac.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20062839

Citation

Norval, Mary, et al. "Is the Action Spectrum for the UV-induced Production of Previtamin D3 in Human Skin Correct?" Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology, vol. 9, no. 1, 2010, pp. 11-7.
Norval M, Björn LO, de Gruijl FR. Is the action spectrum for the UV-induced production of previtamin D3 in human skin correct? Photochem Photobiol Sci. 2010;9(1):11-7.
Norval, M., Björn, L. O., & de Gruijl, F. R. (2010). Is the action spectrum for the UV-induced production of previtamin D3 in human skin correct? Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology, 9(1), 11-7. https://doi.org/10.1039/b9pp00012g
Norval M, Björn LO, de Gruijl FR. Is the Action Spectrum for the UV-induced Production of Previtamin D3 in Human Skin Correct. Photochem Photobiol Sci. 2010;9(1):11-7. PubMed PMID: 20062839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is the action spectrum for the UV-induced production of previtamin D3 in human skin correct? AU - Norval,Mary, AU - Björn,Lars Olof, AU - de Gruijl,Frank R, Y1 - 2009/10/19/ PY - 2010/1/12/entrez PY - 2010/1/12/pubmed PY - 2010/7/20/medline SP - 11 EP - 7 JF - Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology JO - Photochem Photobiol Sci VL - 9 IS - 1 N2 - The universally recognised action spectrum for the UV-induced conversion of 7-dehydrocholesterol to previtamin D(3) in human skin was published in 1982, and indicates a maximum at about 297 nm with essentially no production above 315 nm. This work represents a milestone in research on vitamin D, but limitations in the original data should be recognised. Various findings have arisen in recent years which cast doubts on the accuracy of the action spectrum and its application for spectral weighting in calculations of effective UV doses. In conclusion, the construction of an entirely new computational model to predict previtamin D levels is recommended. SN - 1474-9092 UR - https://www.unboundmedicine.com/medline/citation/20062839/Is_the_action_spectrum_for_the_UV_induced_production_of_previtamin_D3_in_human_skin_correct L2 - https://doi.org/10.1039/b9pp00012g DB - PRIME DP - Unbound Medicine ER -