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Involvement of dorsal hippocampal alpha-adrenergic receptors in the effect of scopolamine on memory retrieval in inhibitory avoidance task.
Neurobiol Learn Mem. 2010 May; 93(4):455-62.NL

Abstract

The present study evaluated the possible role of alpha-adrenergic receptors of the dorsal hippocampus on scopolamine-induced amnesia and scopolamine state-dependent memory in adult male Wistar rats. The animals were bilaterally implanted with chronic cannulae in the CA1 regions of the dorsal hippocampus, trained in a step-through type inhibitory avoidance task, and tested 24h after training to measure step-through latency. Results indicate that post-training or pre-test intra-CA1 administration of scopolamine (1 and 2 microg/rat) dose-dependently reduced the step-through latency, showing an amnestic response. Amnesia produced by post-training scopolamine (2 microg/rat) was reversed by pre-test administration of the scopolamine that is due to a state-dependent effect. Interestingly, pre-test intra-CA1 microinjection of alpha1-adrenergic agonist, phenylephrine (1 and 2 microg/rat) or alpha2-adrenergic agonist, clonidine improved post-training scopolamine (2 microg/rat)-induced retrieval impairment. Furthermore, pre-test intra-CA1 microinjection of phenylephrine (0.25, 0.5 and 1 microg/rat) or clonidine (0.25, 0.5 and 1 microg/rat) with an ineffective dose of scopolamine (0.25 microg/rat), synergistically improved memory performance impaired by post-training scopolamine. On the other hand, pre-test injection of alpha1-receptors antagonist prazosin (1 and 2 microg/rat) or alpha2-receptors antagonist yohimbine (1 and 2 microg/rat) prevented the restoration of memory by pre-test scopolamine. It is important to note that pre-test intra-CA1 administration of the same doses of prazosin or yohimbine, alone did not affect memory retrieval. These results suggest that alpha1- and alpha2-adrenergic receptors of the dorsal hippocampal CA1 regions may play an important role in scopolamine-induced amnesia and scopolamine state-dependent memory.

Authors+Show Affiliations

Department of Biology, Sciences and Research Branch, Islamic Azad University, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20064624

Citation

Azami, Nasrin-Sadat, et al. "Involvement of Dorsal Hippocampal Alpha-adrenergic Receptors in the Effect of Scopolamine On Memory Retrieval in Inhibitory Avoidance Task." Neurobiology of Learning and Memory, vol. 93, no. 4, 2010, pp. 455-62.
Azami NS, Piri M, Oryan S, et al. Involvement of dorsal hippocampal alpha-adrenergic receptors in the effect of scopolamine on memory retrieval in inhibitory avoidance task. Neurobiol Learn Mem. 2010;93(4):455-62.
Azami, N. S., Piri, M., Oryan, S., Jahanshahi, M., Babapour, V., & Zarrindast, M. R. (2010). Involvement of dorsal hippocampal alpha-adrenergic receptors in the effect of scopolamine on memory retrieval in inhibitory avoidance task. Neurobiology of Learning and Memory, 93(4), 455-62. https://doi.org/10.1016/j.nlm.2010.01.003
Azami NS, et al. Involvement of Dorsal Hippocampal Alpha-adrenergic Receptors in the Effect of Scopolamine On Memory Retrieval in Inhibitory Avoidance Task. Neurobiol Learn Mem. 2010;93(4):455-62. PubMed PMID: 20064624.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of dorsal hippocampal alpha-adrenergic receptors in the effect of scopolamine on memory retrieval in inhibitory avoidance task. AU - Azami,Nasrin-Sadat, AU - Piri,Morteza, AU - Oryan,Shahrbano, AU - Jahanshahi,Mehrdad, AU - Babapour,Vahab, AU - Zarrindast,Mohammad-Reza, Y1 - 2010/01/11/ PY - 2009/08/25/received PY - 2010/01/02/revised PY - 2010/01/06/accepted PY - 2010/1/13/entrez PY - 2010/1/13/pubmed PY - 2010/7/31/medline SP - 455 EP - 62 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 93 IS - 4 N2 - The present study evaluated the possible role of alpha-adrenergic receptors of the dorsal hippocampus on scopolamine-induced amnesia and scopolamine state-dependent memory in adult male Wistar rats. The animals were bilaterally implanted with chronic cannulae in the CA1 regions of the dorsal hippocampus, trained in a step-through type inhibitory avoidance task, and tested 24h after training to measure step-through latency. Results indicate that post-training or pre-test intra-CA1 administration of scopolamine (1 and 2 microg/rat) dose-dependently reduced the step-through latency, showing an amnestic response. Amnesia produced by post-training scopolamine (2 microg/rat) was reversed by pre-test administration of the scopolamine that is due to a state-dependent effect. Interestingly, pre-test intra-CA1 microinjection of alpha1-adrenergic agonist, phenylephrine (1 and 2 microg/rat) or alpha2-adrenergic agonist, clonidine improved post-training scopolamine (2 microg/rat)-induced retrieval impairment. Furthermore, pre-test intra-CA1 microinjection of phenylephrine (0.25, 0.5 and 1 microg/rat) or clonidine (0.25, 0.5 and 1 microg/rat) with an ineffective dose of scopolamine (0.25 microg/rat), synergistically improved memory performance impaired by post-training scopolamine. On the other hand, pre-test injection of alpha1-receptors antagonist prazosin (1 and 2 microg/rat) or alpha2-receptors antagonist yohimbine (1 and 2 microg/rat) prevented the restoration of memory by pre-test scopolamine. It is important to note that pre-test intra-CA1 administration of the same doses of prazosin or yohimbine, alone did not affect memory retrieval. These results suggest that alpha1- and alpha2-adrenergic receptors of the dorsal hippocampal CA1 regions may play an important role in scopolamine-induced amnesia and scopolamine state-dependent memory. SN - 1095-9564 UR - https://www.unboundmedicine.com/medline/citation/20064624/Involvement_of_dorsal_hippocampal_alpha_adrenergic_receptors_in_the_effect_of_scopolamine_on_memory_retrieval_in_inhibitory_avoidance_task_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(10)00004-3 DB - PRIME DP - Unbound Medicine ER -