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Efficacy of tramadol in combination with doxepin or venlafaxine in inhibition of nociceptive process in the rat model of neuropathic pain: an isobolographic analysis.
J Physiol Pharmacol. 2009 Dec; 60(4):71-8.JP

Abstract

Neuropathic pain constitutes a serious therapeutic problem. In most cases polytherapy is necessary. Tramadol and antidepressants have common mechanisms of action and are frequently used together in clinical practice, thus interaction between them is very important. In the present study isobolographic analysis for equivalent doses of drugs was applied to examine the nature of interaction between tramadol and doxepin or venlafaxine in a neuropathic pain model in rats. Allodynia and hyperalgesia were assessed after intraperitoneal administration of each drug alone or in combination. Dose response curves were obtained and ED(50) doses were calculated. All drugs were effective in reducing thermal hyperalgesia and mechanical allodynia, however doxepin was more effective than venlafaxine. Combined administration of tramadol and doxepin demonstrated synergistic action in reducing thermal hyperalgesia and additive action in reducing mechanical allodynia. Combined administration of tramadol and venlafaxine showed additive action in reducing hyperalgesia and allodynia. Moreover, combined administration of tramadol and doxepin was more effective than combined administration of tramadol and venlafaxine. The experiments demonstrated that the nature of interaction between tramadol and doxepin is synergistic, which is not the case for tramadol and venlafaxine, what provides a valuable information referring to clinical practice, rationalizing administration of such drug combination.

Authors+Show Affiliations

Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20065499

Citation

Wrzosek, A, et al. "Efficacy of Tramadol in Combination With Doxepin or Venlafaxine in Inhibition of Nociceptive Process in the Rat Model of Neuropathic Pain: an Isobolographic Analysis." Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, vol. 60, no. 4, 2009, pp. 71-8.
Wrzosek A, Obara I, Wordliczek J, et al. Efficacy of tramadol in combination with doxepin or venlafaxine in inhibition of nociceptive process in the rat model of neuropathic pain: an isobolographic analysis. J Physiol Pharmacol. 2009;60(4):71-8.
Wrzosek, A., Obara, I., Wordliczek, J., & Przewlocka, B. (2009). Efficacy of tramadol in combination with doxepin or venlafaxine in inhibition of nociceptive process in the rat model of neuropathic pain: an isobolographic analysis. Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 60(4), 71-8.
Wrzosek A, et al. Efficacy of Tramadol in Combination With Doxepin or Venlafaxine in Inhibition of Nociceptive Process in the Rat Model of Neuropathic Pain: an Isobolographic Analysis. J Physiol Pharmacol. 2009;60(4):71-8. PubMed PMID: 20065499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of tramadol in combination with doxepin or venlafaxine in inhibition of nociceptive process in the rat model of neuropathic pain: an isobolographic analysis. AU - Wrzosek,A, AU - Obara,I, AU - Wordliczek,J, AU - Przewlocka,B, PY - 2008/12/18/received PY - 2009/11/06/accepted PY - 2010/1/13/entrez PY - 2010/1/13/pubmed PY - 2010/4/3/medline SP - 71 EP - 8 JF - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JO - J Physiol Pharmacol VL - 60 IS - 4 N2 - Neuropathic pain constitutes a serious therapeutic problem. In most cases polytherapy is necessary. Tramadol and antidepressants have common mechanisms of action and are frequently used together in clinical practice, thus interaction between them is very important. In the present study isobolographic analysis for equivalent doses of drugs was applied to examine the nature of interaction between tramadol and doxepin or venlafaxine in a neuropathic pain model in rats. Allodynia and hyperalgesia were assessed after intraperitoneal administration of each drug alone or in combination. Dose response curves were obtained and ED(50) doses were calculated. All drugs were effective in reducing thermal hyperalgesia and mechanical allodynia, however doxepin was more effective than venlafaxine. Combined administration of tramadol and doxepin demonstrated synergistic action in reducing thermal hyperalgesia and additive action in reducing mechanical allodynia. Combined administration of tramadol and venlafaxine showed additive action in reducing hyperalgesia and allodynia. Moreover, combined administration of tramadol and doxepin was more effective than combined administration of tramadol and venlafaxine. The experiments demonstrated that the nature of interaction between tramadol and doxepin is synergistic, which is not the case for tramadol and venlafaxine, what provides a valuable information referring to clinical practice, rationalizing administration of such drug combination. SN - 1899-1505 UR - https://www.unboundmedicine.com/medline/citation/20065499/Efficacy_of_tramadol_in_combination_with_doxepin_or_venlafaxine_in_inhibition_of_nociceptive_process_in_the_rat_model_of_neuropathic_pain:_an_isobolographic_analysis_ L2 - http://www.jpp.krakow.pl/journal/archive/12_09/pdf/71_12_09_article.pdf DB - PRIME DP - Unbound Medicine ER -