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NGF and BDNF: from nerves to adipose tissue, from neurokines to metabokines.
Riv Psichiatr 2009 Mar-Apr; 44(2):79-87RP

Abstract

Neurotrophins, particularly, NGF and BDNF are now well recognized to mediate a dizzying number of trophobiological effects, ranging from the Rita Levi-Montalcini's neurotrophic through immunotrophic to metabotrophic effects.These are implicated in the pathogenesis of various diseases including neuropsychiatric and cardiometabolic diseases, such as dementia, depression, type 2 diabetes and obesity that may express a common phenotype and coexistence. Recently, adipobiology (adiposcience) as become a focus of numerous studies showing that the adipose tissue is the body's largest endocrine organ producing multiple signaling proteins, including NGF and BDNF, all these dubbed adipokines. On the basis of our and other authors' evidence that low NGF and/or BDNF levels are found in cardiometabolic diseases (atherosclerosis, obesity, type 2 diabetes, metabolic syndrome), a hypothesis of a critical role of neuro-metabotrophic deficit in the pathogenesis of these diseases has been raised. Since NGF and BDNF also exerts various synaptotrophic effects involved in cognitive enhancement, this hypothesis might also be related to neuropsychiatric diseases such as dementia, depression, schizophrenia, autism, Rett syndrome, anorexia nervosa, and bulimia nervosa. Finally, NGF- and BDNF-based therapeutic approach, including ampakines, antidepressants, selective deacetylase inhibitors, statins, peroxisome proliferator-activated receptor gamma agonists, and "brain food" and calorie restriction, is outlined.

Authors+Show Affiliations

Division of Cell Biology, Medical University, Varna, Bulgaria. chaldakov@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20066808

Citation

Chaldakov, George N., et al. "NGF and BDNF: From Nerves to Adipose Tissue, From Neurokines to Metabokines." Rivista Di Psichiatria, vol. 44, no. 2, 2009, pp. 79-87.
Chaldakov GN, Tonchev AB, Aloe L. NGF and BDNF: from nerves to adipose tissue, from neurokines to metabokines. Riv Psichiatr. 2009;44(2):79-87.
Chaldakov, G. N., Tonchev, A. B., & Aloe, L. (2009). NGF and BDNF: from nerves to adipose tissue, from neurokines to metabokines. Rivista Di Psichiatria, 44(2), pp. 79-87.
Chaldakov GN, Tonchev AB, Aloe L. NGF and BDNF: From Nerves to Adipose Tissue, From Neurokines to Metabokines. Riv Psichiatr. 2009;44(2):79-87. PubMed PMID: 20066808.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - NGF and BDNF: from nerves to adipose tissue, from neurokines to metabokines. AU - Chaldakov,George N, AU - Tonchev,Anton B, AU - Aloe,Luigi, PY - 2010/1/14/entrez PY - 2010/1/14/pubmed PY - 2010/3/2/medline SP - 79 EP - 87 JF - Rivista di psichiatria JO - Riv Psichiatr VL - 44 IS - 2 N2 - Neurotrophins, particularly, NGF and BDNF are now well recognized to mediate a dizzying number of trophobiological effects, ranging from the Rita Levi-Montalcini's neurotrophic through immunotrophic to metabotrophic effects.These are implicated in the pathogenesis of various diseases including neuropsychiatric and cardiometabolic diseases, such as dementia, depression, type 2 diabetes and obesity that may express a common phenotype and coexistence. Recently, adipobiology (adiposcience) as become a focus of numerous studies showing that the adipose tissue is the body's largest endocrine organ producing multiple signaling proteins, including NGF and BDNF, all these dubbed adipokines. On the basis of our and other authors' evidence that low NGF and/or BDNF levels are found in cardiometabolic diseases (atherosclerosis, obesity, type 2 diabetes, metabolic syndrome), a hypothesis of a critical role of neuro-metabotrophic deficit in the pathogenesis of these diseases has been raised. Since NGF and BDNF also exerts various synaptotrophic effects involved in cognitive enhancement, this hypothesis might also be related to neuropsychiatric diseases such as dementia, depression, schizophrenia, autism, Rett syndrome, anorexia nervosa, and bulimia nervosa. Finally, NGF- and BDNF-based therapeutic approach, including ampakines, antidepressants, selective deacetylase inhibitors, statins, peroxisome proliferator-activated receptor gamma agonists, and "brain food" and calorie restriction, is outlined. SN - 0035-6484 UR - https://www.unboundmedicine.com/medline/citation/20066808/full_citation DB - PRIME DP - Unbound Medicine ER -