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[IgM-lambda multiple myeloma presenting with systemic amyloidosis].
Rinsho Ketsueki. 2009 Dec; 50(12):1711-4.RK

Abstract

A 59-year-old man was referred to our hospital due to nephrotic syndrome with IgM paraproteinemia. Physical examination demonstrated marked hepatomegaly and anasarca. Serum M-protein was 0.94 g/dl and urinary analysis detected the presence of Bence Jones protein. Bone marrow plasma cell count was 11.2%. Histological examination demonstrated AL-type amyloid deposition in the liver, kidneys, bone marrow, stomach and rectum. These findings led to a diagnosis of IgM multiple myeloma with systemic amyloidosis. Although there was no apparent response to 2 courses of vincristine, doxorubicin and dexamethasone (VAD) regimen, subsequent treatment with bortezomib in combination with dexamethasone resulted in a rapid reduction in M protein to 0.49 g/dl, approximately half the pre-treatment level.

Authors+Show Affiliations

Depertment of Medicine and Clinical Science, Gunma University Graduate School of Medicine.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

20068279

Citation

Higeta, Daisuke, et al. "[IgM-lambda Multiple Myeloma Presenting With Systemic Amyloidosis]." [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, vol. 50, no. 12, 2009, pp. 1711-4.
Higeta D, Yokohama A, Osaki Y, et al. [IgM-lambda multiple myeloma presenting with systemic amyloidosis]. Rinsho Ketsueki. 2009;50(12):1711-4.
Higeta, D., Yokohama, A., Osaki, Y., Tahara, K., Mawatari, M., Sekigami, T., Koiso, H., Saito, T., Uchiumi, H., Handa, H., Karasawa, M., Murakami, H., Hirato, J., Tsukamoto, N., & Nojima, Y. (2009). [IgM-lambda multiple myeloma presenting with systemic amyloidosis]. [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, 50(12), 1711-4.
Higeta D, et al. [IgM-lambda Multiple Myeloma Presenting With Systemic Amyloidosis]. Rinsho Ketsueki. 2009;50(12):1711-4. PubMed PMID: 20068279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [IgM-lambda multiple myeloma presenting with systemic amyloidosis]. AU - Higeta,Daisuke, AU - Yokohama,Akihiko, AU - Osaki,Youhei, AU - Tahara,Kenichi, AU - Mawatari,Momoko, AU - Sekigami,Tomomi, AU - Koiso,Hiromi, AU - Saito,Takayuki, AU - Uchiumi,Hideki, AU - Handa,Hiroshi, AU - Karasawa,Masamitsu, AU - Murakami,Hirokazu, AU - Hirato,Jyunko, AU - Tsukamoto,Norifumi, AU - Nojima,Yoshihisa, PY - 2010/1/14/entrez PY - 2010/1/14/pubmed PY - 2010/3/4/medline SP - 1711 EP - 4 JF - [Rinsho ketsueki] The Japanese journal of clinical hematology JO - Rinsho Ketsueki VL - 50 IS - 12 N2 - A 59-year-old man was referred to our hospital due to nephrotic syndrome with IgM paraproteinemia. Physical examination demonstrated marked hepatomegaly and anasarca. Serum M-protein was 0.94 g/dl and urinary analysis detected the presence of Bence Jones protein. Bone marrow plasma cell count was 11.2%. Histological examination demonstrated AL-type amyloid deposition in the liver, kidneys, bone marrow, stomach and rectum. These findings led to a diagnosis of IgM multiple myeloma with systemic amyloidosis. Although there was no apparent response to 2 courses of vincristine, doxorubicin and dexamethasone (VAD) regimen, subsequent treatment with bortezomib in combination with dexamethasone resulted in a rapid reduction in M protein to 0.49 g/dl, approximately half the pre-treatment level. SN - 0485-1439 UR - https://www.unboundmedicine.com/medline/citation/20068279/[IgM_lambda_multiple_myeloma_presenting_with_systemic_amyloidosis]_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/rinketsu/50.1711?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -