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Total body bone mineral content and density during weight loss and maintenance on a low- or recommended-dairy weight-maintenance diet in obese men and women.
Eur J Clin Nutr 2010; 64(4):392-9EJ

Abstract

BACKGROUND

Diets high in either dairy or calcium during moderate weight reduction both prevent loss of bone mineral density (BMD) and suppress bone turnover. The purpose of this study was to determine whether recommended dairy and calcium intakes during weight maintenance favorably affect total body BMD (TBBMD) and bone mineral content (TBBMC) in obese adults.

METHODS

Obese men (n=49) and women (n=64), aged 40.8+/-0.6 years, underwent 12 weeks of moderate energy restriction (approximately 1200 kcal/day) followed by 24 weeks on either a low or recommended dairy weight maintenance diet. The TBBMC and TBBMD values were measured using dual energy X-ray absorptiometry at baseline, 12, 24 and 36 weeks. Concentrations of calcium, intact parathyroid hormone (iPTH), 25OH and 1,25 (OH)(2) vitamin D in plasma were also measured. Data were analyzed using a two-factor repeated measures analysis of variance.

RESULTS

After weight loss, women exhibited a small, but statistically significant, increase in TBBMC (1.17+/-0.57%), whereas TBBMD increased in the men (1.34+/-0.28%). The iPTH concentration decreased significantly in all subjects. Despite significantly greater intakes of calcium, vitamin D and protein compared with the recommended dairy diet, there were no treatment-related differences in outcome variables after 24 weeks of weight maintenance. The TBBMC remained unchanged in women during weight stabilization; both TBBMC and TBBMD decreased in men (-1.59+/-0.51% and -0.70+/-0.25%, respectively).

CONCLUSIONS

In summary, results of this study do not provide convincing evidence that moderate weight loss through energy restriction and mild exercise reduces TBBMC in obese men and women. Similarly, a weight-maintenance diet providing the recommended daily servings of dairy does not seem to affect changes in BMC after weight loss.

Authors+Show Affiliations

Department of Nutritional Sciences, University of Missouri, Columbia, MO 65211, USA. hintonp@missouri.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

20068585

Citation

Hinton, P S., et al. "Total Body Bone Mineral Content and Density During Weight Loss and Maintenance On a Low- or Recommended-dairy Weight-maintenance Diet in Obese Men and Women." European Journal of Clinical Nutrition, vol. 64, no. 4, 2010, pp. 392-9.
Hinton PS, Rector RS, Donnelly JE, et al. Total body bone mineral content and density during weight loss and maintenance on a low- or recommended-dairy weight-maintenance diet in obese men and women. Eur J Clin Nutr. 2010;64(4):392-9.
Hinton, P. S., Rector, R. S., Donnelly, J. E., Smith, B. K., & Bailey, B. (2010). Total body bone mineral content and density during weight loss and maintenance on a low- or recommended-dairy weight-maintenance diet in obese men and women. European Journal of Clinical Nutrition, 64(4), pp. 392-9. doi:10.1038/ejcn.2009.156.
Hinton PS, et al. Total Body Bone Mineral Content and Density During Weight Loss and Maintenance On a Low- or Recommended-dairy Weight-maintenance Diet in Obese Men and Women. Eur J Clin Nutr. 2010;64(4):392-9. PubMed PMID: 20068585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Total body bone mineral content and density during weight loss and maintenance on a low- or recommended-dairy weight-maintenance diet in obese men and women. AU - Hinton,P S, AU - Rector,R Scott, AU - Donnelly,J E, AU - Smith,B K, AU - Bailey,B, Y1 - 2010/01/13/ PY - 2010/1/14/entrez PY - 2010/1/14/pubmed PY - 2010/10/12/medline SP - 392 EP - 9 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 64 IS - 4 N2 - BACKGROUND: Diets high in either dairy or calcium during moderate weight reduction both prevent loss of bone mineral density (BMD) and suppress bone turnover. The purpose of this study was to determine whether recommended dairy and calcium intakes during weight maintenance favorably affect total body BMD (TBBMD) and bone mineral content (TBBMC) in obese adults. METHODS: Obese men (n=49) and women (n=64), aged 40.8+/-0.6 years, underwent 12 weeks of moderate energy restriction (approximately 1200 kcal/day) followed by 24 weeks on either a low or recommended dairy weight maintenance diet. The TBBMC and TBBMD values were measured using dual energy X-ray absorptiometry at baseline, 12, 24 and 36 weeks. Concentrations of calcium, intact parathyroid hormone (iPTH), 25OH and 1,25 (OH)(2) vitamin D in plasma were also measured. Data were analyzed using a two-factor repeated measures analysis of variance. RESULTS: After weight loss, women exhibited a small, but statistically significant, increase in TBBMC (1.17+/-0.57%), whereas TBBMD increased in the men (1.34+/-0.28%). The iPTH concentration decreased significantly in all subjects. Despite significantly greater intakes of calcium, vitamin D and protein compared with the recommended dairy diet, there were no treatment-related differences in outcome variables after 24 weeks of weight maintenance. The TBBMC remained unchanged in women during weight stabilization; both TBBMC and TBBMD decreased in men (-1.59+/-0.51% and -0.70+/-0.25%, respectively). CONCLUSIONS: In summary, results of this study do not provide convincing evidence that moderate weight loss through energy restriction and mild exercise reduces TBBMC in obese men and women. Similarly, a weight-maintenance diet providing the recommended daily servings of dairy does not seem to affect changes in BMC after weight loss. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/20068585/Total_body_bone_mineral_content_and_density_during_weight_loss_and_maintenance_on_a_low__or_recommended_dairy_weight_maintenance_diet_in_obese_men_and_women_ L2 - http://dx.doi.org/10.1038/ejcn.2009.156 DB - PRIME DP - Unbound Medicine ER -