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Self-assembled chitosan/heparin multilayer film as a novel template for in situ synthesis of silver nanoparticles.
Colloids Surf B Biointerfaces. 2010 Apr 01; 76(2):549-55.CS

Abstract

Chitosan and heparin multilayer films were successfully constructed via layer-by-layer self assembly. These films were used as a polymeric template to synthesize silver nanoparticles. The silver concentration and nanoparticle size can be simply controlled by the assembly pH and loading pH, as demonstrated by UV-visible spectroscopy, transmission electron microscopy and atomic absorbance spectroscopy. The pH tunable uncompensated charge density within the multilayer films is believed to have great effect on the loading of silver ions, and then control the size and amount of silver nanoparticles within multilayer films. The antibacterial experiment shows that the silver nanoparticle-loaded chitosan/heparin multilayer films exhibit greatly enhanced antibacterial performance compared to the chitosan/heparin multilayer films without silver nanoparticles. In addition, the strong antibacterial property of silver nanoparticle-loaded films can last more than 1 month. Our method of in situ synthesis of metal nanoparticles in biocompatible multilayer films might provide great potential to design biofunctional nanocomposite films.

Authors+Show Affiliations

Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, PR China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20071156

Citation

Yuan, Weiyong, et al. "Self-assembled Chitosan/heparin Multilayer Film as a Novel Template for in Situ Synthesis of Silver Nanoparticles." Colloids and Surfaces. B, Biointerfaces, vol. 76, no. 2, 2010, pp. 549-55.
Yuan W, Fu J, Su K, et al. Self-assembled chitosan/heparin multilayer film as a novel template for in situ synthesis of silver nanoparticles. Colloids Surf B Biointerfaces. 2010;76(2):549-55.
Yuan, W., Fu, J., Su, K., & Ji, J. (2010). Self-assembled chitosan/heparin multilayer film as a novel template for in situ synthesis of silver nanoparticles. Colloids and Surfaces. B, Biointerfaces, 76(2), 549-55. https://doi.org/10.1016/j.colsurfb.2009.12.017
Yuan W, et al. Self-assembled Chitosan/heparin Multilayer Film as a Novel Template for in Situ Synthesis of Silver Nanoparticles. Colloids Surf B Biointerfaces. 2010 Apr 1;76(2):549-55. PubMed PMID: 20071156.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Self-assembled chitosan/heparin multilayer film as a novel template for in situ synthesis of silver nanoparticles. AU - Yuan,Weiyong, AU - Fu,Jinhong, AU - Su,Kai, AU - Ji,Jian, Y1 - 2009/12/28/ PY - 2009/10/20/received PY - 2009/12/10/revised PY - 2009/12/18/accepted PY - 2010/1/15/entrez PY - 2010/1/15/pubmed PY - 2010/4/30/medline SP - 549 EP - 55 JF - Colloids and surfaces. B, Biointerfaces JO - Colloids Surf B Biointerfaces VL - 76 IS - 2 N2 - Chitosan and heparin multilayer films were successfully constructed via layer-by-layer self assembly. These films were used as a polymeric template to synthesize silver nanoparticles. The silver concentration and nanoparticle size can be simply controlled by the assembly pH and loading pH, as demonstrated by UV-visible spectroscopy, transmission electron microscopy and atomic absorbance spectroscopy. The pH tunable uncompensated charge density within the multilayer films is believed to have great effect on the loading of silver ions, and then control the size and amount of silver nanoparticles within multilayer films. The antibacterial experiment shows that the silver nanoparticle-loaded chitosan/heparin multilayer films exhibit greatly enhanced antibacterial performance compared to the chitosan/heparin multilayer films without silver nanoparticles. In addition, the strong antibacterial property of silver nanoparticle-loaded films can last more than 1 month. Our method of in situ synthesis of metal nanoparticles in biocompatible multilayer films might provide great potential to design biofunctional nanocomposite films. SN - 1873-4367 UR - https://www.unboundmedicine.com/medline/citation/20071156/Self_assembled_chitosan/heparin_multilayer_film_as_a_novel_template_for_in_situ_synthesis_of_silver_nanoparticles_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0927-7765(09)00620-1 DB - PRIME DP - Unbound Medicine ER -