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Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan.
Am J Clin Nutr. 2010 Mar; 91(3):722-8.AJ

Abstract

BACKGROUND

Although case-control studies support the idea that soy foods or isoflavone intake is associated with a decreased risk of lung cancer, little evidence is available from prospective cohort studies. Moreover, no prospective study has addressed this association in men.

OBJECTIVE

We investigated the association between isoflavone intake and lung cancer incidence.

DESIGN

We conducted a population-based prospective cohort study in 36,177 men and 40,484 women aged 45-74 y with no history of cancer at baseline in 1995-1999. Participants responded to a validated questionnaire, which included 138 food items. We used Cox proportional hazards regression analysis to estimate the hazard ratios (HRs) and 95% CIs of lung cancer incidence according to isoflavone intake, which was estimated by genistein content from soy foods.

RESULTS

During 11 y (671,864 person-years) of follow-up, we documented 481 male and 178 female lung cancer cases. In men we found an inverse association between isoflavone intake and risk of lung cancer in never smokers (n = 13,051; multivariate HR in the highest compared with the lowest quartile of isoflavone intake: 0.43; 95% CI: 0.21, 0.90; P for trend = 0.024) but not in current or past smokers. A similar, nonsignificant inverse association was seen in never-smoking women (n = 38,211; HR: 0.67; 95% CI: 0.41, 1.10; P for trend = 0.135). We also tested effect modification by smoking status (P for interaction = 0.085 in men and 0.055 in men and women combined).

CONCLUSION

In a large-scale, population-based, prospective study in Japan, isoflavone intake was associated with a decreased risk of lung cancer in never smokers.

Authors+Show Affiliations

Research Center for Cancer Prevention and Screening, National Cancer Center Tokyo Japan. tshimazu@ncc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20071645

Citation

Shimazu, Taichi, et al. "Isoflavone Intake and Risk of Lung Cancer: a Prospective Cohort Study in Japan." The American Journal of Clinical Nutrition, vol. 91, no. 3, 2010, pp. 722-8.
Shimazu T, Inoue M, Sasazuki S, et al. Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan. Am J Clin Nutr. 2010;91(3):722-8.
Shimazu, T., Inoue, M., Sasazuki, S., Iwasaki, M., Sawada, N., Yamaji, T., & Tsugane, S. (2010). Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan. The American Journal of Clinical Nutrition, 91(3), 722-8. https://doi.org/10.3945/ajcn.2009.28161
Shimazu T, et al. Isoflavone Intake and Risk of Lung Cancer: a Prospective Cohort Study in Japan. Am J Clin Nutr. 2010;91(3):722-8. PubMed PMID: 20071645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan. AU - Shimazu,Taichi, AU - Inoue,Manami, AU - Sasazuki,Shizuka, AU - Iwasaki,Motoki, AU - Sawada,Norie, AU - Yamaji,Taiki, AU - Tsugane,Shoichiro, AU - ,, Y1 - 2010/01/13/ PY - 2010/1/15/entrez PY - 2010/1/15/pubmed PY - 2010/3/31/medline SP - 722 EP - 8 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 91 IS - 3 N2 - BACKGROUND: Although case-control studies support the idea that soy foods or isoflavone intake is associated with a decreased risk of lung cancer, little evidence is available from prospective cohort studies. Moreover, no prospective study has addressed this association in men. OBJECTIVE: We investigated the association between isoflavone intake and lung cancer incidence. DESIGN: We conducted a population-based prospective cohort study in 36,177 men and 40,484 women aged 45-74 y with no history of cancer at baseline in 1995-1999. Participants responded to a validated questionnaire, which included 138 food items. We used Cox proportional hazards regression analysis to estimate the hazard ratios (HRs) and 95% CIs of lung cancer incidence according to isoflavone intake, which was estimated by genistein content from soy foods. RESULTS: During 11 y (671,864 person-years) of follow-up, we documented 481 male and 178 female lung cancer cases. In men we found an inverse association between isoflavone intake and risk of lung cancer in never smokers (n = 13,051; multivariate HR in the highest compared with the lowest quartile of isoflavone intake: 0.43; 95% CI: 0.21, 0.90; P for trend = 0.024) but not in current or past smokers. A similar, nonsignificant inverse association was seen in never-smoking women (n = 38,211; HR: 0.67; 95% CI: 0.41, 1.10; P for trend = 0.135). We also tested effect modification by smoking status (P for interaction = 0.085 in men and 0.055 in men and women combined). CONCLUSION: In a large-scale, population-based, prospective study in Japan, isoflavone intake was associated with a decreased risk of lung cancer in never smokers. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/20071645/Isoflavone_intake_and_risk_of_lung_cancer:_a_prospective_cohort_study_in_Japan_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.28161 DB - PRIME DP - Unbound Medicine ER -