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Coupling genetics and post-genomic approaches to decipher the cellular splicing code at a systems-wide level.
Biochem Soc Trans. 2010 Feb; 38(Pt 1):237-41.BS

Abstract

Nuclear RNA processing is a critical stage in eukaryotic gene expression, and is controlled in part by the expression and concentration of nuclear RNA-binding proteins. Different nuclear RNA-binding proteins are differentially expressed in different cells, helping the spliceosome to decode pre-mRNAs into alternatively spliced mRNAs. Recent post-genomic technology has exposed the complexity of nuclear RNA processing, and is starting to reveal the mechanisms and rules through which networks of RNA-binding proteins can regulate multiple parallel pathways. Identification of multiple parallel processing pathways regulated by nuclear RNA-binding proteins is leading to a systems-wide understanding of the rules and consequences of alternative nuclear RNA processing.

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Authors+Show Affiliations

Liu Y
Institute of Human Genetics, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.
Elliott DJ
No affiliation info available

MeSH

GenomeGenomicsHumansRNA PrecursorsRNA SplicingRNA-Binding ProteinsSELEX Aptamer Technique

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20074067

Citation

Liu, Yilei, and David J. Elliott. "Coupling Genetics and Post-genomic Approaches to Decipher the Cellular Splicing Code at a Systems-wide Level." Biochemical Society Transactions, vol. 38, no. Pt 1, 2010, pp. 237-41.
Liu Y, Elliott DJ. Coupling genetics and post-genomic approaches to decipher the cellular splicing code at a systems-wide level. Biochem Soc Trans. 2010;38(Pt 1):237-41.
Liu, Y., & Elliott, D. J. (2010). Coupling genetics and post-genomic approaches to decipher the cellular splicing code at a systems-wide level. Biochemical Society Transactions, 38(Pt 1), 237-41. https://doi.org/10.1042/BST0380237
Liu Y, Elliott DJ. Coupling Genetics and Post-genomic Approaches to Decipher the Cellular Splicing Code at a Systems-wide Level. Biochem Soc Trans. 2010;38(Pt 1):237-41. PubMed PMID: 20074067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coupling genetics and post-genomic approaches to decipher the cellular splicing code at a systems-wide level. AU - Liu,Yilei, AU - Elliott,David J, PY - 2010/1/16/entrez PY - 2010/1/16/pubmed PY - 2010/3/17/medline SP - 237 EP - 41 JF - Biochemical Society transactions JO - Biochem Soc Trans VL - 38 IS - Pt 1 N2 - Nuclear RNA processing is a critical stage in eukaryotic gene expression, and is controlled in part by the expression and concentration of nuclear RNA-binding proteins. Different nuclear RNA-binding proteins are differentially expressed in different cells, helping the spliceosome to decode pre-mRNAs into alternatively spliced mRNAs. Recent post-genomic technology has exposed the complexity of nuclear RNA processing, and is starting to reveal the mechanisms and rules through which networks of RNA-binding proteins can regulate multiple parallel pathways. Identification of multiple parallel processing pathways regulated by nuclear RNA-binding proteins is leading to a systems-wide understanding of the rules and consequences of alternative nuclear RNA processing. SN - 1470-8752 UR - https://www.unboundmedicine.com/medline/citation/20074067/Coupling_genetics_and_post_genomic_approaches_to_decipher_the_cellular_splicing_code_at_a_systems_wide_level_ L2 - https://portlandpress.com/biochemsoctrans/article-lookup/doi/10.1042/BST0380237 DB - PRIME DP - Unbound Medicine ER -