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Effect of PD98059, a selective MAPK3/MAPK1 inhibitor, on acute lung injury in mice.
Int J Immunopathol Pharmacol. 2009 Oct-Dec; 22(4):937-50.IJ

Abstract

The aim of the present study is to evaluate the contribution of mitogen-activated protein kinase 1-3 MAPK3/MAPK1) in a model of acute lung inflammation in mice. Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by: accumulation of fluid containing a large number of neutrophils (PMNs) in the pleural cavity, infiltration of PMNs in lung tissues and subsequent adhesion molecule expression (I-CAM and P-selectin), lipid peroxidation, and increased production of tumour necrosis factor-alpha, (TNF-alpha) and interleukin-1beta (IL-1beta). Furthermore, carrageenan induced lung apoptosis (Bax and Bcl-2 expression) as well as nitrotyrosine formation, NF-kB activation, and pJNK expression, as determined by immunohistochemical analysis of lung tissues and the degree of lung inflammation and tissue injury (histological score). Administration of PD98059, an inhibitor of MAPK3/MAPK1 (10 mg/kg) 1 h after carrageenan caused a reduction in all the parameters of inflammation measured. Thus, based on these findings we propose that inhibitors of the MAPK3/MAPK1 signaling pathways, such as PD98059, may be useful in the treatment of various inflammatory diseases.

Authors+Show Affiliations

IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20074457

Citation

Di Paola, R, et al. "Effect of PD98059, a Selective MAPK3/MAPK1 Inhibitor, On Acute Lung Injury in Mice." International Journal of Immunopathology and Pharmacology, vol. 22, no. 4, 2009, pp. 937-50.
Di Paola R, Crisafulli C, Mazzon E, et al. Effect of PD98059, a selective MAPK3/MAPK1 inhibitor, on acute lung injury in mice. Int J Immunopathol Pharmacol. 2009;22(4):937-50.
Di Paola, R., Crisafulli, C., Mazzon, E., Genovese, T., Paterniti, I., Bramanti, P., & Cuzzocrea, S. (2009). Effect of PD98059, a selective MAPK3/MAPK1 inhibitor, on acute lung injury in mice. International Journal of Immunopathology and Pharmacology, 22(4), 937-50.
Di Paola R, et al. Effect of PD98059, a Selective MAPK3/MAPK1 Inhibitor, On Acute Lung Injury in Mice. Int J Immunopathol Pharmacol. 2009 Oct-Dec;22(4):937-50. PubMed PMID: 20074457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of PD98059, a selective MAPK3/MAPK1 inhibitor, on acute lung injury in mice. AU - Di Paola,R, AU - Crisafulli,C, AU - Mazzon,E, AU - Genovese,T, AU - Paterniti,I, AU - Bramanti,P, AU - Cuzzocrea,S, PY - 2010/1/16/entrez PY - 2010/1/16/pubmed PY - 2010/3/23/medline SP - 937 EP - 50 JF - International journal of immunopathology and pharmacology JO - Int J Immunopathol Pharmacol VL - 22 IS - 4 N2 - The aim of the present study is to evaluate the contribution of mitogen-activated protein kinase 1-3 MAPK3/MAPK1) in a model of acute lung inflammation in mice. Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by: accumulation of fluid containing a large number of neutrophils (PMNs) in the pleural cavity, infiltration of PMNs in lung tissues and subsequent adhesion molecule expression (I-CAM and P-selectin), lipid peroxidation, and increased production of tumour necrosis factor-alpha, (TNF-alpha) and interleukin-1beta (IL-1beta). Furthermore, carrageenan induced lung apoptosis (Bax and Bcl-2 expression) as well as nitrotyrosine formation, NF-kB activation, and pJNK expression, as determined by immunohistochemical analysis of lung tissues and the degree of lung inflammation and tissue injury (histological score). Administration of PD98059, an inhibitor of MAPK3/MAPK1 (10 mg/kg) 1 h after carrageenan caused a reduction in all the parameters of inflammation measured. Thus, based on these findings we propose that inhibitors of the MAPK3/MAPK1 signaling pathways, such as PD98059, may be useful in the treatment of various inflammatory diseases. SN - 0394-6320 UR - https://www.unboundmedicine.com/medline/citation/20074457/Effect_of_PD98059_a_selective_MAPK3/MAPK1_inhibitor_on_acute_lung_injury_in_mice_ L2 - https://journals.sagepub.com/doi/10.1177/039463200902200409?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -