Type your tag names separated by a space and hit enter

Effect of bee venom on transforming growth factor-beta1-treated hepatocytes.

Abstract

Bee venom (BV) has been used as treatment against a wide variety of ailments, including inflammatory diseases. Various studies have demonstrated anti-inflammatory and anticancer effects of BV. Transforming growth factor (TGF)-beta1 induces hepatocyte apoptosis via the mitochondrial permeability transition. However, there is no evidence or information regarding the antiapoptotic effect of BV on hepatocytes. The authors investigated the antiapoptotic effect of BV on TGF-beta1-treated hepatocytes. The results showed significant protection from DNA damage by BV treatment compared to corresponding TGF-beta1-treated hepatocytes without BV. BV suppressed TGF-beta1-induced activation of the bcl-2 family and caspase family of proteins, which resulted in inhibition of poly ADP-ribose polymerase (PARP) cleavage. Furthermore, BV is not cytotoxic in the low concentrations used in this study. Low concentrations of BV potently suppress the apoptotic response in TGF-beta1-treated hepatocytes; therefore, BV may have therapeutic potential for the treatment of liver diseases.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Rehabilitation Medicine, Eulji University Hospital, Daejeon, South Korea.

    , , , , ,

    Source

    MeSH

    Animals
    Apoptosis
    Bee Venoms
    Cell Line
    Cell Survival
    DNA Fragmentation
    Dose-Response Relationship, Drug
    Formazans
    Hepatocytes
    Mice
    Poly(ADP-ribose) Polymerase Inhibitors
    Poly(ADP-ribose) Polymerases
    Protective Agents
    Proto-Oncogene Proteins c-bcl-2
    Tetrazolium Salts
    Transforming Growth Factor beta

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20075187

    Citation

    Park, Jung-Hyun, et al. "Effect of Bee Venom On Transforming Growth Factor-beta1-treated Hepatocytes." International Journal of Toxicology, vol. 29, no. 1, 2010, pp. 49-56.
    Park JH, Kim KH, Kim SJ, et al. Effect of bee venom on transforming growth factor-beta1-treated hepatocytes. Int J Toxicol. 2010;29(1):49-56.
    Park, J. H., Kim, K. H., Kim, S. J., Lee, W. R., Lee, K. G., Park, J. H., & Park, K. K. (2010). Effect of bee venom on transforming growth factor-beta1-treated hepatocytes. International Journal of Toxicology, 29(1), pp. 49-56. doi:10.1177/1091581809353948.
    Park JH, et al. Effect of Bee Venom On Transforming Growth Factor-beta1-treated Hepatocytes. Int J Toxicol. 2010;29(1):49-56. PubMed PMID: 20075187.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of bee venom on transforming growth factor-beta1-treated hepatocytes. AU - Park,Jung-Hyun, AU - Kim,Kyung-Hyun, AU - Kim,Soo-Jung, AU - Lee,Woo-Ram, AU - Lee,Kwang-Gill, AU - Park,Ji-Hyun, AU - Park,Kwan-Kyu, PY - 2010/1/16/entrez PY - 2010/1/16/pubmed PY - 2010/3/24/medline SP - 49 EP - 56 JF - International journal of toxicology JO - Int. J. Toxicol. VL - 29 IS - 1 N2 - Bee venom (BV) has been used as treatment against a wide variety of ailments, including inflammatory diseases. Various studies have demonstrated anti-inflammatory and anticancer effects of BV. Transforming growth factor (TGF)-beta1 induces hepatocyte apoptosis via the mitochondrial permeability transition. However, there is no evidence or information regarding the antiapoptotic effect of BV on hepatocytes. The authors investigated the antiapoptotic effect of BV on TGF-beta1-treated hepatocytes. The results showed significant protection from DNA damage by BV treatment compared to corresponding TGF-beta1-treated hepatocytes without BV. BV suppressed TGF-beta1-induced activation of the bcl-2 family and caspase family of proteins, which resulted in inhibition of poly ADP-ribose polymerase (PARP) cleavage. Furthermore, BV is not cytotoxic in the low concentrations used in this study. Low concentrations of BV potently suppress the apoptotic response in TGF-beta1-treated hepatocytes; therefore, BV may have therapeutic potential for the treatment of liver diseases. SN - 1092-874X UR - https://www.unboundmedicine.com/medline/citation/20075187/Effect_of_bee_venom_on_transforming_growth_factor_beta1_treated_hepatocytes_ L2 - http://journals.sagepub.com/doi/full/10.1177/1091581809353948?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -