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Potential of stratus optical coherence tomography for detecting early glaucoma in perimetrically normal eyes of open-angle glaucoma patients with unilateral visual field loss.
J Glaucoma 2010; 19(1):61-5JG

Abstract

PURPOSE

To evaluate the potential of stratus optical coherence tomography (OCT) for detecting early glaucoma.

PATIENTS AND METHODS

Fifty-two open-angle glaucoma patients with unilateral visual field loss detected by standard automatic perimetry were tested using stratus OCT and frequency doubling technology (FDT) N-30. Fifty-two perimetrically normal eyes were enrolled and divided into 2 groups: eyes with normal OCT results and eyes with abnormal OCT results. FDT parameters and scores were compared between the 2 groups. We evaluated the topographic relationship of the OCT-measured retinal nerve fiber layer (RNFL) defects with the FDT-measured visual field loss and glaucomatous optic neuropathy.

RESULTS

In eyes with abnormal OCT results, the percentage of eyes with abnormal FDT results was significantly higher (P<0.001); FDT mean deviation, pattern standard deviation, and scores were significantly worse than those with normal OCT results (P=0.005, P<0.001, P<0.001, respectively); and the OCT-measured RNFL defects showed good topographic agreement with the FDT-measured visual field loss and glaucomatous optic neuropathy.

CONCLUSIONS

RNFL defects detected by stratus OCT were associated with FDT visual field loss. Stratus OCT can detect early glaucoma sooner than standard automatic perimetry.

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    Authors+Show Affiliations

    Zhang Y
    Peking University Third Hospital, Peking University Eye Center, Beijing, China.
    Wu LL
    No affiliation info available
    Yang YF
    No affiliation info available

    MeSH

    AdultAgedEarly DiagnosisFemaleGlaucoma, Open-AngleHumansIntraocular PressureLow Tension GlaucomaMaleMiddle AgedNerve FibersOptic DiskOptic Nerve DiseasesRetinal Ganglion CellsTomography, Optical CoherenceTonometry, OcularVision DisordersVisual Field TestsVisual FieldsYoung Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    20075675

    Citation

    Zhang, Yu, et al. "Potential of Stratus Optical Coherence Tomography for Detecting Early Glaucoma in Perimetrically Normal Eyes of Open-angle Glaucoma Patients With Unilateral Visual Field Loss." Journal of Glaucoma, vol. 19, no. 1, 2010, pp. 61-5.
    Zhang Y, Wu LL, Yang YF. Potential of stratus optical coherence tomography for detecting early glaucoma in perimetrically normal eyes of open-angle glaucoma patients with unilateral visual field loss. J Glaucoma. 2010;19(1):61-5.
    Zhang, Y., Wu, L. L., & Yang, Y. F. (2010). Potential of stratus optical coherence tomography for detecting early glaucoma in perimetrically normal eyes of open-angle glaucoma patients with unilateral visual field loss. Journal of Glaucoma, 19(1), pp. 61-5. doi:10.1097/IJG.0b013e31819c486b.
    Zhang Y, Wu LL, Yang YF. Potential of Stratus Optical Coherence Tomography for Detecting Early Glaucoma in Perimetrically Normal Eyes of Open-angle Glaucoma Patients With Unilateral Visual Field Loss. J Glaucoma. 2010;19(1):61-5. PubMed PMID: 20075675.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Potential of stratus optical coherence tomography for detecting early glaucoma in perimetrically normal eyes of open-angle glaucoma patients with unilateral visual field loss. AU - Zhang,Yu, AU - Wu,Ling-Ling, AU - Yang,Yan-Fang, PY - 2010/1/16/entrez PY - 2010/1/16/pubmed PY - 2010/3/20/medline SP - 61 EP - 5 JF - Journal of glaucoma JO - J. Glaucoma VL - 19 IS - 1 N2 - PURPOSE: To evaluate the potential of stratus optical coherence tomography (OCT) for detecting early glaucoma. PATIENTS AND METHODS: Fifty-two open-angle glaucoma patients with unilateral visual field loss detected by standard automatic perimetry were tested using stratus OCT and frequency doubling technology (FDT) N-30. Fifty-two perimetrically normal eyes were enrolled and divided into 2 groups: eyes with normal OCT results and eyes with abnormal OCT results. FDT parameters and scores were compared between the 2 groups. We evaluated the topographic relationship of the OCT-measured retinal nerve fiber layer (RNFL) defects with the FDT-measured visual field loss and glaucomatous optic neuropathy. RESULTS: In eyes with abnormal OCT results, the percentage of eyes with abnormal FDT results was significantly higher (P<0.001); FDT mean deviation, pattern standard deviation, and scores were significantly worse than those with normal OCT results (P=0.005, P<0.001, P<0.001, respectively); and the OCT-measured RNFL defects showed good topographic agreement with the FDT-measured visual field loss and glaucomatous optic neuropathy. CONCLUSIONS: RNFL defects detected by stratus OCT were associated with FDT visual field loss. Stratus OCT can detect early glaucoma sooner than standard automatic perimetry. SN - 1536-481X UR - https://www.unboundmedicine.com/medline/citation/20075675/Potential_of_stratus_optical_coherence_tomography_for_detecting_early_glaucoma_in_perimetrically_normal_eyes_of_open_angle_glaucoma_patients_with_unilateral_visual_field_loss_ L2 - http://dx.doi.org/10.1097/IJG.0b013e31819c486b DB - PRIME DP - Unbound Medicine ER -