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Monitoring of mycophenolate acid in serum or plasma using LC tandem mass spectrometry.
Methods Mol Biol. 2010; 603:379-87.MM

Abstract

Therapeutic drug management of patients receiving mycophenolic mofetil or mycophenolate sodium using mycophenolic acid (MPA) concentrations is controversial. Considered to be less toxic compared to many of the other drugs used in immunosuppression regimens, MPA is not tolerated by all patients. For these patients, monitoring is useful in achieving desired therapeutic targets, reducing adverse effects, and individualizing dosing. We describe an LC-MS-MS that permits the measurement of MPA and 7-O-glucuronide mycophenolic acid (MPAG) in serum or plasma.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Hammett-Stabler CA
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Geis DC
No affiliation info available
Ritchie JC
No affiliation info available
Papadea C
No affiliation info available

MeSH

Chromatography, LiquidGlucuronidesHumansImmunosuppressive AgentsMycophenolic AcidReproducibility of ResultsTandem Mass Spectrometry

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20077090

Citation

Hammett-Stabler, Catherine A., et al. "Monitoring of Mycophenolate Acid in Serum or Plasma Using LC Tandem Mass Spectrometry." Methods in Molecular Biology (Clifton, N.J.), vol. 603, 2010, pp. 379-87.
Hammett-Stabler CA, Geis DC, Ritchie JC, et al. Monitoring of mycophenolate acid in serum or plasma using LC tandem mass spectrometry. Methods Mol Biol. 2010;603:379-87.
Hammett-Stabler, C. A., Geis, D. C., Ritchie, J. C., & Papadea, C. (2010). Monitoring of mycophenolate acid in serum or plasma using LC tandem mass spectrometry. Methods in Molecular Biology (Clifton, N.J.), 603, 379-87. https://doi.org/10.1007/978-1-60761-459-3_37
Hammett-Stabler CA, et al. Monitoring of Mycophenolate Acid in Serum or Plasma Using LC Tandem Mass Spectrometry. Methods Mol Biol. 2010;603:379-87. PubMed PMID: 20077090.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Monitoring of mycophenolate acid in serum or plasma using LC tandem mass spectrometry. AU - Hammett-Stabler,Catherine A, AU - Geis,Diane Ciuffetti, AU - Ritchie,James C, AU - Papadea,Christine, PY - 2010/1/16/entrez PY - 2010/1/16/pubmed PY - 2010/4/7/medline SP - 379 EP - 87 JF - Methods in molecular biology (Clifton, N.J.) JO - Methods Mol Biol VL - 603 N2 - Therapeutic drug management of patients receiving mycophenolic mofetil or mycophenolate sodium using mycophenolic acid (MPA) concentrations is controversial. Considered to be less toxic compared to many of the other drugs used in immunosuppression regimens, MPA is not tolerated by all patients. For these patients, monitoring is useful in achieving desired therapeutic targets, reducing adverse effects, and individualizing dosing. We describe an LC-MS-MS that permits the measurement of MPA and 7-O-glucuronide mycophenolic acid (MPAG) in serum or plasma. SN - 1940-6029 UR - https://www.unboundmedicine.com/medline/citation/20077090/Monitoring_of_mycophenolate_acid_in_serum_or_plasma_using_LC_tandem_mass_spectrometry_ L2 - https://dx.doi.org/10.1007/978-1-60761-459-3_37 DB - PRIME DP - Unbound Medicine ER -

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