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Nitrates in municipal drinking water and non-Hodgkin lymphoma: an ecological cancer case-control study in Taiwan.
J Toxicol Environ Health A. 2010; 73(4):330-8.JT

Abstract

The relationship between nitrate levels in drinking water and increased risk of non-Hodgkin lymphoma (NHL) development has been inconclusive. A matched cancer case-control and a nitrate ecology study was used to investigate the association between mortality attributed to NHL and nitrate exposure from Taiwan's drinking water. All deaths due to NHL in Taiwan residents from 2000 through 2006 were obtained from the Bureau of Vital Statistics of the Taiwan Provincial Department of Health. Controls were deaths from other causes and were pair-matched to the cases by gender, year of birth, and year of death. Each matched control was selected randomly from the set of possible controls for each case. Data on nitrate-nitrogen (NO(3)-N) levels of drinking water throughout Taiwan were collected from the Taiwan Water Supply Corporation (TWSC). The municipality of residence for cancer cases and controls was presumed to be the source of the subject's nitrate exposure via drinking water. The adjusted odds ratios (OR) for NHL death for those with high nitrate levels in their drinking water, as compared to the lowest tertile, were 1.02 (0.87-1.2) and 1.05 (0.89-1.24), respectively. The results of the present study show that there was no statistically significant association between nitrates in drinking water at levels in this investigation and increased risk of death attributed to NHL.

Authors+Show Affiliations

Department of Environmental and Occupational Health, National Cheng Kung University, Tainan, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20077301

Citation

Chang, Chih-Ching, et al. "Nitrates in Municipal Drinking Water and non-Hodgkin Lymphoma: an Ecological Cancer Case-control Study in Taiwan." Journal of Toxicology and Environmental Health. Part A, vol. 73, no. 4, 2010, pp. 330-8.
Chang CC, Tsai SS, Wu TN, et al. Nitrates in municipal drinking water and non-Hodgkin lymphoma: an ecological cancer case-control study in Taiwan. J Toxicol Environ Health Part A. 2010;73(4):330-8.
Chang, C. C., Tsai, S. S., Wu, T. N., & Yang, C. Y. (2010). Nitrates in municipal drinking water and non-Hodgkin lymphoma: an ecological cancer case-control study in Taiwan. Journal of Toxicology and Environmental Health. Part A, 73(4), 330-8. https://doi.org/10.1080/15287390903421243
Chang CC, et al. Nitrates in Municipal Drinking Water and non-Hodgkin Lymphoma: an Ecological Cancer Case-control Study in Taiwan. J Toxicol Environ Health Part A. 2010;73(4):330-8. PubMed PMID: 20077301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nitrates in municipal drinking water and non-Hodgkin lymphoma: an ecological cancer case-control study in Taiwan. AU - Chang,Chih-Ching, AU - Tsai,Shang-Shyue, AU - Wu,Trong-Neng, AU - Yang,Chun-Yuh, PY - 2010/1/16/entrez PY - 2010/1/16/pubmed PY - 2010/2/6/medline SP - 330 EP - 8 JF - Journal of toxicology and environmental health. Part A JO - J. Toxicol. Environ. Health Part A VL - 73 IS - 4 N2 - The relationship between nitrate levels in drinking water and increased risk of non-Hodgkin lymphoma (NHL) development has been inconclusive. A matched cancer case-control and a nitrate ecology study was used to investigate the association between mortality attributed to NHL and nitrate exposure from Taiwan's drinking water. All deaths due to NHL in Taiwan residents from 2000 through 2006 were obtained from the Bureau of Vital Statistics of the Taiwan Provincial Department of Health. Controls were deaths from other causes and were pair-matched to the cases by gender, year of birth, and year of death. Each matched control was selected randomly from the set of possible controls for each case. Data on nitrate-nitrogen (NO(3)-N) levels of drinking water throughout Taiwan were collected from the Taiwan Water Supply Corporation (TWSC). The municipality of residence for cancer cases and controls was presumed to be the source of the subject's nitrate exposure via drinking water. The adjusted odds ratios (OR) for NHL death for those with high nitrate levels in their drinking water, as compared to the lowest tertile, were 1.02 (0.87-1.2) and 1.05 (0.89-1.24), respectively. The results of the present study show that there was no statistically significant association between nitrates in drinking water at levels in this investigation and increased risk of death attributed to NHL. SN - 1528-7394 UR - https://www.unboundmedicine.com/medline/citation/20077301/Nitrates_in_municipal_drinking_water_and_non_Hodgkin_lymphoma:_an_ecological_cancer_case_control_study_in_Taiwan_ L2 - http://www.tandfonline.com/doi/full/10.1080/15287390903421243 DB - PRIME DP - Unbound Medicine ER -