Tags

Type your tag names separated by a space and hit enter

Comparison of four definitions of the metabolic syndrome in a Greek (Mediterranean) population.
Curr Med Res Opin. 2010 Mar; 26(3):713-9.CM

Abstract

BACKGROUND

There is a need to evaluate the prevalence of metabolic syndrome (MetS) diagnosed by the new Joint Interim Societies (JIS) MetS definition. The JIS definition was compared with three previous definitions to assess their ability to predict cardiovascular disease (CVD) risk.

METHODS

A cross-sectional analysis of a representative sample of Greek adults (n = 9669) was performed to estimate the prevalence of MetS and CVD using the JIS vs. the three older definitions of MetS: the National Cholesterol Education Program-Adult Treatment Panel-III (NCEP-ATP-III), the International Diabetes Federation (IDF) and the American Heart Association/National Heart Lung and Blood Institute (AHA/NHLBI) definitions.

RESULTS

The age-adjusted MetS prevalence was 45.7%, 43.4%, 24.5% and 26.3% (ANOVA p < 0.001) with the JIS, IDF, NCEP and AHA/NHLBI definitions. The prevalence of CVD was 11.4% in the whole study population and 17.6%, 18.3%, 23.3%, 22.6% and in subjects with MetS according to the JIS, IDF, NCEP and AHA/NHLBI definitions (ANOVA p < 0.001). The prevalence of CVD was only 10.4% (i.e., lower than in the whole study population) in subjects with MetS according to the JIS but not according to the NCEP-ATP-III and AHA/NHLBI definitions (p < 0.001 vs. subjects with MetS as defined by NCEP-ATP-III or AHA/NHLBI).

CONCLUSIONS

When diagnosed according to the new JIS definition, the prevalence of MetS was high in a Greek Mediterranean cohort (nearly half of the adult population). The NCEP-ATP-III and AHA/NHLBI definitions were more predictive of CVD risk than the new JIS definition. These findings, though limited by the cross sectional analysis, may have implications regarding the choice of the definition to diagnose MetS.

Authors+Show Affiliations

Second Propedeutic Department of Internal Medicine, Aristotelian University, Hippocration Hospital, Thessaloniki, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20078335

Citation

Athyros, Vasilios G., et al. "Comparison of Four Definitions of the Metabolic Syndrome in a Greek (Mediterranean) Population." Current Medical Research and Opinion, vol. 26, no. 3, 2010, pp. 713-9.
Athyros VG, Ganotakis ES, Tziomalos K, et al. Comparison of four definitions of the metabolic syndrome in a Greek (Mediterranean) population. Curr Med Res Opin. 2010;26(3):713-9.
Athyros, V. G., Ganotakis, E. S., Tziomalos, K., Papageorgiou, A. A., Anagnostis, P., Griva, T., Kargiotis, K., Mitsiou, E. K., Karagiannis, A., & Mikhailidis, D. P. (2010). Comparison of four definitions of the metabolic syndrome in a Greek (Mediterranean) population. Current Medical Research and Opinion, 26(3), 713-9. https://doi.org/10.1185/03007991003590597
Athyros VG, et al. Comparison of Four Definitions of the Metabolic Syndrome in a Greek (Mediterranean) Population. Curr Med Res Opin. 2010;26(3):713-9. PubMed PMID: 20078335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of four definitions of the metabolic syndrome in a Greek (Mediterranean) population. AU - Athyros,Vasilios G, AU - Ganotakis,Emmanuel S, AU - Tziomalos,Konstantinos, AU - Papageorgiou,Athanasios A, AU - Anagnostis,Panagiotis, AU - Griva,Theodora, AU - Kargiotis,Konstantinos, AU - Mitsiou,Eydoxia K, AU - Karagiannis,Asterios, AU - Mikhailidis,Dimitri P, PY - 2010/1/19/entrez PY - 2010/1/19/pubmed PY - 2010/5/21/medline SP - 713 EP - 9 JF - Current medical research and opinion JO - Curr Med Res Opin VL - 26 IS - 3 N2 - BACKGROUND: There is a need to evaluate the prevalence of metabolic syndrome (MetS) diagnosed by the new Joint Interim Societies (JIS) MetS definition. The JIS definition was compared with three previous definitions to assess their ability to predict cardiovascular disease (CVD) risk. METHODS: A cross-sectional analysis of a representative sample of Greek adults (n = 9669) was performed to estimate the prevalence of MetS and CVD using the JIS vs. the three older definitions of MetS: the National Cholesterol Education Program-Adult Treatment Panel-III (NCEP-ATP-III), the International Diabetes Federation (IDF) and the American Heart Association/National Heart Lung and Blood Institute (AHA/NHLBI) definitions. RESULTS: The age-adjusted MetS prevalence was 45.7%, 43.4%, 24.5% and 26.3% (ANOVA p < 0.001) with the JIS, IDF, NCEP and AHA/NHLBI definitions. The prevalence of CVD was 11.4% in the whole study population and 17.6%, 18.3%, 23.3%, 22.6% and in subjects with MetS according to the JIS, IDF, NCEP and AHA/NHLBI definitions (ANOVA p < 0.001). The prevalence of CVD was only 10.4% (i.e., lower than in the whole study population) in subjects with MetS according to the JIS but not according to the NCEP-ATP-III and AHA/NHLBI definitions (p < 0.001 vs. subjects with MetS as defined by NCEP-ATP-III or AHA/NHLBI). CONCLUSIONS: When diagnosed according to the new JIS definition, the prevalence of MetS was high in a Greek Mediterranean cohort (nearly half of the adult population). The NCEP-ATP-III and AHA/NHLBI definitions were more predictive of CVD risk than the new JIS definition. These findings, though limited by the cross sectional analysis, may have implications regarding the choice of the definition to diagnose MetS. SN - 1473-4877 UR - https://www.unboundmedicine.com/medline/citation/20078335/Comparison_of_four_definitions_of_the_metabolic_syndrome_in_a_Greek__Mediterranean__population_ L2 - http://www.tandfonline.com/doi/full/10.1185/03007991003590597 DB - PRIME DP - Unbound Medicine ER -