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Hospitalised adult patients with pandemic (H1N1) 2009 influenza in Melbourne, Australia.
Med J Aust. 2010 Jan 18; 192(2):84-6.MJ

Abstract

OBJECTIVE

To describe the case characteristics and outcomes of patients hospitalised with pandemic (H1N1) 2009 influenza infection during the first 2 months of the epidemic.

DESIGN, PARTICIPANTS AND SETTING

Prospective case series of 112 patients admitted to seven hospitals in Melbourne with laboratory-confirmed pandemic (H1N1) 2009 influenza between 1 May and 17 July 2009.

MAIN OUTCOME MEASURES

Details of case characteristics, risk factors for severe disease, treatment and clinical course.

RESULTS

Of 112 hospitalised patients, most presented with cough (88%) and/or fever (82%), but several (4%) had neither symptom. A quarter of female patients (15) were pregnant or in the post-partum period. Patients presenting with multifocal changes on chest x-ray had significantly longer hospital lengths of stay, and were more likely to require intensive care unit admission. Thirty patients required admission to an intensive care unit, and three died during their acute illness. The median length of intensive care admission was 10.5 days (interquartile range, 5-16 days).

CONCLUSIONS

This study highlights risk factors for severe disease, particularly pregnancy. Clinical and public health planning for upcoming influenza seasons should take into account the spectrum and severity of clinical infection demonstrated in this report, and the need to concentrate resources effectively in high-risk patient groups.

Authors+Show Affiliations

Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, VIC, Australia. justin.denholm@mh.org.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20078408

Citation

Denholm, Justin T., et al. "Hospitalised Adult Patients With Pandemic (H1N1) 2009 Influenza in Melbourne, Australia." The Medical Journal of Australia, vol. 192, no. 2, 2010, pp. 84-6.
Denholm JT, Gordon CL, Johnson PD, et al. Hospitalised adult patients with pandemic (H1N1) 2009 influenza in Melbourne, Australia. Med J Aust. 2010;192(2):84-6.
Denholm, J. T., Gordon, C. L., Johnson, P. D., Hewagama, S. S., Stuart, R. L., Aboltins, C., Jeremiah, C., Knox, J., Lane, G. P., Tramontana, A. R., Slavin, M. A., Schulz, T. R., Richards, M., Birch, C. J., & Cheng, A. C. (2010). Hospitalised adult patients with pandemic (H1N1) 2009 influenza in Melbourne, Australia. The Medical Journal of Australia, 192(2), 84-6.
Denholm JT, et al. Hospitalised Adult Patients With Pandemic (H1N1) 2009 Influenza in Melbourne, Australia. Med J Aust. 2010 Jan 18;192(2):84-6. PubMed PMID: 20078408.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hospitalised adult patients with pandemic (H1N1) 2009 influenza in Melbourne, Australia. AU - Denholm,Justin T, AU - Gordon,Claire L, AU - Johnson,Paul D, AU - Hewagama,Saliya S, AU - Stuart,Rhonda L, AU - Aboltins,Craig, AU - Jeremiah,Cameron, AU - Knox,James, AU - Lane,Garry P, AU - Tramontana,Adrian R, AU - Slavin,Monica A, AU - Schulz,Thomas R, AU - Richards,Michael, AU - Birch,Chris J, AU - Cheng,Allen C, PY - 2009/08/03/received PY - 2009/10/20/accepted PY - 2010/1/19/entrez PY - 2010/1/19/pubmed PY - 2010/3/24/medline SP - 84 EP - 6 JF - The Medical journal of Australia JO - Med. J. Aust. VL - 192 IS - 2 N2 - OBJECTIVE: To describe the case characteristics and outcomes of patients hospitalised with pandemic (H1N1) 2009 influenza infection during the first 2 months of the epidemic. DESIGN, PARTICIPANTS AND SETTING: Prospective case series of 112 patients admitted to seven hospitals in Melbourne with laboratory-confirmed pandemic (H1N1) 2009 influenza between 1 May and 17 July 2009. MAIN OUTCOME MEASURES: Details of case characteristics, risk factors for severe disease, treatment and clinical course. RESULTS: Of 112 hospitalised patients, most presented with cough (88%) and/or fever (82%), but several (4%) had neither symptom. A quarter of female patients (15) were pregnant or in the post-partum period. Patients presenting with multifocal changes on chest x-ray had significantly longer hospital lengths of stay, and were more likely to require intensive care unit admission. Thirty patients required admission to an intensive care unit, and three died during their acute illness. The median length of intensive care admission was 10.5 days (interquartile range, 5-16 days). CONCLUSIONS: This study highlights risk factors for severe disease, particularly pregnancy. Clinical and public health planning for upcoming influenza seasons should take into account the spectrum and severity of clinical infection demonstrated in this report, and the need to concentrate resources effectively in high-risk patient groups. SN - 0025-729X UR - https://www.unboundmedicine.com/medline/citation/20078408/Hospitalised_adult_patients_with_pandemic__H1N1__2009_influenza_in_Melbourne_Australia_ L2 - https://www.mja.com.au/public/issues/192_02_180110/den10902_fm.html DB - PRIME DP - Unbound Medicine ER -