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Comparison of adult patients hospitalised with pandemic (H1N1) 2009 influenza and seasonal influenza during the "PROTECT" phase of the pandemic response.
Med J Aust. 2010 Jan 18; 192(2):90-3.MJ

Abstract

OBJECTIVE

To compare the patient characteristics, clinical features and outcomes of adult patients hospitalised with pandemic (H1N1) 2009 influenza and seasonal influenza.

DESIGN AND SETTING

Retrospective medical record review of all patients admitted to Liverpool Hospital, Sydney, with laboratory-confirmed influenza from the initiation of the "PROTECT" phase of the pandemic response on 17 June until the end of our study period on 31 July 2009.

MAIN OUTCOME MEASURES

Severity of illness; requirement for admission to the intensive care unit (ICU) and/or invasive ventilation; mortality.

RESULTS

Sixty-four adults were admitted to Liverpool Hospital with influenza, 48 with pandemic (H1N1) 2009 influenza and 16 with seasonal influenza. Thirteen patients were admitted to the ICU. Seven required invasive ventilation, with 2 patients requiring ongoing extracorporeal membrane oxygenation (ECMO). Five patients died (mortality rate, 8%) with two deaths occurring after the study period. Patients with pandemic (H1N1) 2009 influenza were younger and less likely to be immunocompromised than patients with seasonal influenza. However, the clinical features of pandemic (H1N1) 2009 influenza and seasonal influenza were similar.

CONCLUSIONS

Our findings show that the clinical course and outcomes of pandemic (H1N1) 2009 influenza virus are comparable to those of the current circulating seasonal influenza in Sydney. The high number of hospital admissions reflects a high incidence of disease in the community rather than an enhanced virulence of the novel pandemic influenza virus.

Authors+Show Affiliations

Department of Respiratory Medicine, Liverpool Hospital, Sydney, NSW, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20078410

Citation

Chang, Ya-Shu, et al. "Comparison of Adult Patients Hospitalised With Pandemic (H1N1) 2009 Influenza and Seasonal Influenza During the "PROTECT" Phase of the Pandemic Response." The Medical Journal of Australia, vol. 192, no. 2, 2010, pp. 90-3.
Chang YS, van Hal SJ, Spencer PM, et al. Comparison of adult patients hospitalised with pandemic (H1N1) 2009 influenza and seasonal influenza during the "PROTECT" phase of the pandemic response. Med J Aust. 2010;192(2):90-3.
Chang, Y. S., van Hal, S. J., Spencer, P. M., Gosbell, I. B., & Collett, P. W. (2010). Comparison of adult patients hospitalised with pandemic (H1N1) 2009 influenza and seasonal influenza during the "PROTECT" phase of the pandemic response. The Medical Journal of Australia, 192(2), 90-3.
Chang YS, et al. Comparison of Adult Patients Hospitalised With Pandemic (H1N1) 2009 Influenza and Seasonal Influenza During the "PROTECT" Phase of the Pandemic Response. Med J Aust. 2010 Jan 18;192(2):90-3. PubMed PMID: 20078410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of adult patients hospitalised with pandemic (H1N1) 2009 influenza and seasonal influenza during the "PROTECT" phase of the pandemic response. AU - Chang,Ya-Shu, AU - van Hal,Sebastiaan J, AU - Spencer,Peter M, AU - Gosbell,Iain B, AU - Collett,Peter W, PY - 2009/08/13/received PY - 2009/11/09/accepted PY - 2010/1/19/entrez PY - 2010/1/19/pubmed PY - 2010/3/24/medline SP - 90 EP - 3 JF - The Medical journal of Australia JO - Med. J. Aust. VL - 192 IS - 2 N2 - OBJECTIVE: To compare the patient characteristics, clinical features and outcomes of adult patients hospitalised with pandemic (H1N1) 2009 influenza and seasonal influenza. DESIGN AND SETTING: Retrospective medical record review of all patients admitted to Liverpool Hospital, Sydney, with laboratory-confirmed influenza from the initiation of the "PROTECT" phase of the pandemic response on 17 June until the end of our study period on 31 July 2009. MAIN OUTCOME MEASURES: Severity of illness; requirement for admission to the intensive care unit (ICU) and/or invasive ventilation; mortality. RESULTS: Sixty-four adults were admitted to Liverpool Hospital with influenza, 48 with pandemic (H1N1) 2009 influenza and 16 with seasonal influenza. Thirteen patients were admitted to the ICU. Seven required invasive ventilation, with 2 patients requiring ongoing extracorporeal membrane oxygenation (ECMO). Five patients died (mortality rate, 8%) with two deaths occurring after the study period. Patients with pandemic (H1N1) 2009 influenza were younger and less likely to be immunocompromised than patients with seasonal influenza. However, the clinical features of pandemic (H1N1) 2009 influenza and seasonal influenza were similar. CONCLUSIONS: Our findings show that the clinical course and outcomes of pandemic (H1N1) 2009 influenza virus are comparable to those of the current circulating seasonal influenza in Sydney. The high number of hospital admissions reflects a high incidence of disease in the community rather than an enhanced virulence of the novel pandemic influenza virus. SN - 0025-729X UR - https://www.unboundmedicine.com/medline/citation/20078410/Comparison_of_adult_patients_hospitalised_with_pandemic__H1N1__2009_influenza_and_seasonal_influenza_during_the_"PROTECT"_phase_of_the_pandemic_response_ L2 - https://www.mja.com.au/public/issues/192_02_180110/cha10960_fm.html DB - PRIME DP - Unbound Medicine ER -