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Hair analysis for drug abuse: I. Determination of methamphetamine and amphetamine in hair by stable isotope dilution gas chromatography/mass spectrometry method.
J Forensic Sci. 1991 Jan; 36(1):70-8.JF

Abstract

Determination of methamphetamine and amphetamine in hair was performed by gas chromatography/mass spectrometry using stable isotope-labeled internal standards, 2-methylamino-1-phenylpropane-2,3,3,3-d4 and 2-amino-1-phenylpropane-2,3,3,3-d4. Extraction of hair with methanol/5M hydrochloric acid (20:1) using ultrasonication was chosen as the standard method. The calibration curves for amphetamines in the hair were linear from 1 to 100 ng/mg (r greater than 0.99). The detection limit was 0.5 ng/mg at the 95% confidence level. The coefficients of variation (CV) (n = 8) of analysis using the spiked hair with methamphetamine were from 0.7 to 6%. The CV (n = 8) of analysis of the methamphetamine abuser's hair was 17.5%. Sectional analysis of monkey and human hair after methamphetamine ingestion suggested a good correlation between the duration of drug use and drug distribution in the hair.

Authors+Show Affiliations

Narcotics Section, National Institute of Hygiene Sciences, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2007882

Citation

Nakahara, Y, et al. "Hair Analysis for Drug Abuse: I. Determination of Methamphetamine and Amphetamine in Hair By Stable Isotope Dilution Gas Chromatography/mass Spectrometry Method." Journal of Forensic Sciences, vol. 36, no. 1, 1991, pp. 70-8.
Nakahara Y, Takahashi K, Shimamine M, et al. Hair analysis for drug abuse: I. Determination of methamphetamine and amphetamine in hair by stable isotope dilution gas chromatography/mass spectrometry method. J Forensic Sci. 1991;36(1):70-8.
Nakahara, Y., Takahashi, K., Shimamine, M., & Takeda, Y. (1991). Hair analysis for drug abuse: I. Determination of methamphetamine and amphetamine in hair by stable isotope dilution gas chromatography/mass spectrometry method. Journal of Forensic Sciences, 36(1), 70-8.
Nakahara Y, et al. Hair Analysis for Drug Abuse: I. Determination of Methamphetamine and Amphetamine in Hair By Stable Isotope Dilution Gas Chromatography/mass Spectrometry Method. J Forensic Sci. 1991;36(1):70-8. PubMed PMID: 2007882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hair analysis for drug abuse: I. Determination of methamphetamine and amphetamine in hair by stable isotope dilution gas chromatography/mass spectrometry method. AU - Nakahara,Y, AU - Takahashi,K, AU - Shimamine,M, AU - Takeda,Y, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 70 EP - 8 JF - Journal of forensic sciences JO - J. Forensic Sci. VL - 36 IS - 1 N2 - Determination of methamphetamine and amphetamine in hair was performed by gas chromatography/mass spectrometry using stable isotope-labeled internal standards, 2-methylamino-1-phenylpropane-2,3,3,3-d4 and 2-amino-1-phenylpropane-2,3,3,3-d4. Extraction of hair with methanol/5M hydrochloric acid (20:1) using ultrasonication was chosen as the standard method. The calibration curves for amphetamines in the hair were linear from 1 to 100 ng/mg (r greater than 0.99). The detection limit was 0.5 ng/mg at the 95% confidence level. The coefficients of variation (CV) (n = 8) of analysis using the spiked hair with methamphetamine were from 0.7 to 6%. The CV (n = 8) of analysis of the methamphetamine abuser's hair was 17.5%. Sectional analysis of monkey and human hair after methamphetamine ingestion suggested a good correlation between the duration of drug use and drug distribution in the hair. SN - 0022-1198 UR - https://www.unboundmedicine.com/medline/citation/2007882/Hair_analysis_for_drug_abuse:_I__Determination_of_methamphetamine_and_amphetamine_in_hair_by_stable_isotope_dilution_gas_chromatography/mass_spectrometry_method_ L2 - https://medlineplus.gov/druguseandaddiction.html DB - PRIME DP - Unbound Medicine ER -