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Dysregulated microRNAs in neurodegenerative disorders.
Semin Cell Dev Biol. 2010 Sep; 21(7):768-73.SC

Abstract

The complexity of the nervous system arises in part, from the large diversity of neural cell types that support the architecture of neuronal circuits. Recent studies have highlighted microRNAs as important players in regulating gene expression at the post-transcriptional level and therefore the phenotype of neural cells. A link between microRNAs and neurodegenerative diseases such as Alzheimer's disease, Huntington's disease and Parkinson's disease is becoming increasingly evident. Here, we discuss microRNAs in neurodegeneration, from the fruit fly and mouse utilized as experimental models to dysregulated microRNAs in human neurodegenerative disorders. We propose that studying microRNAs and their mRNA targets in the context of neurodegeneration will significantly contribute to the identification of proteins important for neuronal function and might reveal underlying molecular networks that drive these diseases.

Authors+Show Affiliations

Center for Human Genetics. K.U. Leuven. Herestraat 49 Bus 602 B-3000 Leuven, Belgium.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20080199

Citation

Lau, Pierre, and Bart de Strooper. "Dysregulated microRNAs in Neurodegenerative Disorders." Seminars in Cell & Developmental Biology, vol. 21, no. 7, 2010, pp. 768-73.
Lau P, de Strooper B. Dysregulated microRNAs in neurodegenerative disorders. Semin Cell Dev Biol. 2010;21(7):768-73.
Lau, P., & de Strooper, B. (2010). Dysregulated microRNAs in neurodegenerative disorders. Seminars in Cell & Developmental Biology, 21(7), 768-73. https://doi.org/10.1016/j.semcdb.2010.01.009
Lau P, de Strooper B. Dysregulated microRNAs in Neurodegenerative Disorders. Semin Cell Dev Biol. 2010;21(7):768-73. PubMed PMID: 20080199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dysregulated microRNAs in neurodegenerative disorders. AU - Lau,Pierre, AU - de Strooper,Bart, Y1 - 2010/01/18/ PY - 2009/11/26/received PY - 2010/01/08/accepted PY - 2010/1/19/entrez PY - 2010/1/19/pubmed PY - 2010/12/14/medline SP - 768 EP - 73 JF - Seminars in cell & developmental biology JO - Semin Cell Dev Biol VL - 21 IS - 7 N2 - The complexity of the nervous system arises in part, from the large diversity of neural cell types that support the architecture of neuronal circuits. Recent studies have highlighted microRNAs as important players in regulating gene expression at the post-transcriptional level and therefore the phenotype of neural cells. A link between microRNAs and neurodegenerative diseases such as Alzheimer's disease, Huntington's disease and Parkinson's disease is becoming increasingly evident. Here, we discuss microRNAs in neurodegeneration, from the fruit fly and mouse utilized as experimental models to dysregulated microRNAs in human neurodegenerative disorders. We propose that studying microRNAs and their mRNA targets in the context of neurodegeneration will significantly contribute to the identification of proteins important for neuronal function and might reveal underlying molecular networks that drive these diseases. SN - 1096-3634 UR - https://www.unboundmedicine.com/medline/citation/20080199/Dysregulated_microRNAs_in_neurodegenerative_disorders_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1084-9521(10)00010-8 DB - PRIME DP - Unbound Medicine ER -