Tags

Type your tag names separated by a space and hit enter

High prevalence of coronary heart disease in type 2 diabetic patients with non-alcoholic fatty liver disease.
Arch Med Res 2009; 40(7):571-5AM

Abstract

BACKGROUND AND AIMS

Nonalcoholic fatty liver disease (NAFLD) is closely associated with insulin resistance and metabolic syndrome. Prevalence of NAFLD increases greatly in patients with type 2 diabetes mellitus (T2DM), and it may also increase cardiovascular disease mortality and morbidity. The aim of our study was to investigate the prevalence of NAFLD in T2DM population and to compare the prevalence of coronary heart disease (CHD) and its risk factors between diabetic patients with and without NAFLD in a Chinese population.

METHODS

A cross-sectional survey was conducted among 560 cases of in-patient T2DM patients from January 2002 to January 2009 in southern China. Patients were divided into two groups (NAFLD and non-NAFLD) and underwent clinical examination, anthropometry, laboratory tests and routine liver ultrasonography.

RESULTS

Prevalence of NAFLD was 75.18% (421 cases) among all participants, and 285 cases (67.70%) had normal liver function and no symptoms. NAFLD group had higher body mass index (BMI), waist/hip circumference ratio (WHR), alanine aminotransferase (ALT), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) levels than those without NAFLD (p<0.01). Moreover, the prevalence of CHD was also higher in the NAFLD group (p<0.01), especially in those male patients with elevated plasma ALT.

CONCLUSIONS

NAFLD is a common condition among T2DM patients. Its occurrence may be related to sex, age, abdominal obesity, dyslipidemia metabolism, etc. and it is associated with a higher prevalence of CHD. Plasma ALT levels may act as a marker.

Authors+Show Affiliations

Department of Endocrinology, the Third Affiliated Hospital of Sun Yat-sen University, Guangdong, Guangzhou, China. luhongyun1120@yahoo.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20082871

Citation

Lu, Hongyun, et al. "High Prevalence of Coronary Heart Disease in Type 2 Diabetic Patients With Non-alcoholic Fatty Liver Disease." Archives of Medical Research, vol. 40, no. 7, 2009, pp. 571-5.
Lu H, Zeng L, Liang B, et al. High prevalence of coronary heart disease in type 2 diabetic patients with non-alcoholic fatty liver disease. Arch Med Res. 2009;40(7):571-5.
Lu, H., Zeng, L., Liang, B., Shu, X., & Xie, D. (2009). High prevalence of coronary heart disease in type 2 diabetic patients with non-alcoholic fatty liver disease. Archives of Medical Research, 40(7), pp. 571-5. doi:10.1016/j.arcmed.2009.07.009.
Lu H, et al. High Prevalence of Coronary Heart Disease in Type 2 Diabetic Patients With Non-alcoholic Fatty Liver Disease. Arch Med Res. 2009;40(7):571-5. PubMed PMID: 20082871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High prevalence of coronary heart disease in type 2 diabetic patients with non-alcoholic fatty liver disease. AU - Lu,Hongyun, AU - Zeng,Longyi, AU - Liang,Biao, AU - Shu,Xiaochun, AU - Xie,Danhong, Y1 - 2009/09/25/ PY - 2009/05/20/received PY - 2009/07/02/accepted PY - 2010/1/20/entrez PY - 2010/1/20/pubmed PY - 2010/3/24/medline SP - 571 EP - 5 JF - Archives of medical research JO - Arch. Med. Res. VL - 40 IS - 7 N2 - BACKGROUND AND AIMS: Nonalcoholic fatty liver disease (NAFLD) is closely associated with insulin resistance and metabolic syndrome. Prevalence of NAFLD increases greatly in patients with type 2 diabetes mellitus (T2DM), and it may also increase cardiovascular disease mortality and morbidity. The aim of our study was to investigate the prevalence of NAFLD in T2DM population and to compare the prevalence of coronary heart disease (CHD) and its risk factors between diabetic patients with and without NAFLD in a Chinese population. METHODS: A cross-sectional survey was conducted among 560 cases of in-patient T2DM patients from January 2002 to January 2009 in southern China. Patients were divided into two groups (NAFLD and non-NAFLD) and underwent clinical examination, anthropometry, laboratory tests and routine liver ultrasonography. RESULTS: Prevalence of NAFLD was 75.18% (421 cases) among all participants, and 285 cases (67.70%) had normal liver function and no symptoms. NAFLD group had higher body mass index (BMI), waist/hip circumference ratio (WHR), alanine aminotransferase (ALT), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) levels than those without NAFLD (p<0.01). Moreover, the prevalence of CHD was also higher in the NAFLD group (p<0.01), especially in those male patients with elevated plasma ALT. CONCLUSIONS: NAFLD is a common condition among T2DM patients. Its occurrence may be related to sex, age, abdominal obesity, dyslipidemia metabolism, etc. and it is associated with a higher prevalence of CHD. Plasma ALT levels may act as a marker. SN - 1873-5487 UR - https://www.unboundmedicine.com/medline/citation/20082871/High_prevalence_of_coronary_heart_disease_in_type_2_diabetic_patients_with_non_alcoholic_fatty_liver_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0188-4409(09)00135-0 DB - PRIME DP - Unbound Medicine ER -