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Plastic effects of L-DOPA treatment in the basal ganglia and their relevance to the development of dyskinesia.
Parkinsonism Relat Disord. 2009 Dec; 15 Suppl 3:S59-63.PR

Abstract

The development of L-DOPA-induced dyskinesia (LID) is attributed to plastic responses triggered by dopamine (DA) receptor stimulation in the parkinsonian brain. This article reviews studies that have uncovered different levels of maladaptive plasticity in animal models of LID. Rats developing dyskinesia on chronic L-DOPA treatment show abnormal patterns of signaling pathway activation and synaptic plasticity in striatal neurons. In addition, these animals show a gene expression profile indicative of structural cellular plasticity, including pronounced upregulation of genes involved in extracellular matrix remodeling, neurite extension, synaptic vesicle trafficking, and endothelial and cellular proliferation. Structural changes of neurons and microvessels within the basal ganglia are currently being unraveled by detailed morphological analyses. The structural and functional adaptations induced by L-DOPA in the brain can be viewed as an attempt to meet increased metabolic demands and to boost cellular defense mechanisms. These homeostatic responses, however, also predispose to the appearance of dyskinesia and other complications during the course of the treatment.

Authors+Show Affiliations

Basal Ganglia Pathophysiology Unit, Dept. Experimental Medical Science, Lund University, BMC F11, 221 84 Lund, Sweden. Angela.Cenci_Nilsson@med.lu.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20083009

Citation

Cenci, M Angela, et al. "Plastic Effects of L-DOPA Treatment in the Basal Ganglia and Their Relevance to the Development of Dyskinesia." Parkinsonism & Related Disorders, vol. 15 Suppl 3, 2009, pp. S59-63.
Cenci MA, Ohlin KE, Rylander D. Plastic effects of L-DOPA treatment in the basal ganglia and their relevance to the development of dyskinesia. Parkinsonism Relat Disord. 2009;15 Suppl 3:S59-63.
Cenci, M. A., Ohlin, K. E., & Rylander, D. (2009). Plastic effects of L-DOPA treatment in the basal ganglia and their relevance to the development of dyskinesia. Parkinsonism & Related Disorders, 15 Suppl 3, S59-63. https://doi.org/10.1016/S1353-8020(09)70782-5
Cenci MA, Ohlin KE, Rylander D. Plastic Effects of L-DOPA Treatment in the Basal Ganglia and Their Relevance to the Development of Dyskinesia. Parkinsonism Relat Disord. 2009;15 Suppl 3:S59-63. PubMed PMID: 20083009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plastic effects of L-DOPA treatment in the basal ganglia and their relevance to the development of dyskinesia. AU - Cenci,M Angela, AU - Ohlin,K Elisabet, AU - Rylander,Daniella, PY - 2010/1/20/entrez PY - 2010/1/30/pubmed PY - 2010/4/1/medline SP - S59 EP - 63 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 15 Suppl 3 N2 - The development of L-DOPA-induced dyskinesia (LID) is attributed to plastic responses triggered by dopamine (DA) receptor stimulation in the parkinsonian brain. This article reviews studies that have uncovered different levels of maladaptive plasticity in animal models of LID. Rats developing dyskinesia on chronic L-DOPA treatment show abnormal patterns of signaling pathway activation and synaptic plasticity in striatal neurons. In addition, these animals show a gene expression profile indicative of structural cellular plasticity, including pronounced upregulation of genes involved in extracellular matrix remodeling, neurite extension, synaptic vesicle trafficking, and endothelial and cellular proliferation. Structural changes of neurons and microvessels within the basal ganglia are currently being unraveled by detailed morphological analyses. The structural and functional adaptations induced by L-DOPA in the brain can be viewed as an attempt to meet increased metabolic demands and to boost cellular defense mechanisms. These homeostatic responses, however, also predispose to the appearance of dyskinesia and other complications during the course of the treatment. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/20083009/Plastic_effects_of_L_DOPA_treatment_in_the_basal_ganglia_and_their_relevance_to_the_development_of_dyskinesia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(09)70782-5 DB - PRIME DP - Unbound Medicine ER -