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Small bowel bacterial overgrowth and type 1 diabetes.
Eur Rev Med Pharmacol Sci 2009 Nov-Dec; 13(6):419-23ER

Abstract

BACKGROUND

Gastrointestinal motility disorders are often present in diabetic patients (pts). Such motility dysfunctions have been attributed to autonomic neuropathy. Impaired intestinal motility is often associated with small-bowel bacterial overgrowth (SIBO) but only few studies evaluated the relationship between autonomic neuropathy and SIBO in diabetic pts.

AIM

To compare the prevalence of SIBO between type 1 diabetic (T1D) pts with and without autonomic neuropathy.

PATIENTS AND METHODS

25 pts (13 males, 12 females; mean age 44.2+/-7) affected by type 1 diabetes with normal cardiovascular autonomic test (group A) and 25 type 1 diabetic pts with abnormal cardiovascular autonomic test (group B) were submitted to hydrogen lactulose breath test.

RESULTS

2 out of 25 (8%) showed SIBO among group A, while 11 out of 25 (44%) showed SIBO among group B (p<0.01). Interestingly, among group B, the daily insulin requirements was significantly higher in SIBO-positive pts compared to SIBO-negative: 0.66+/-0.3 vs. 0.59+/-0.1 UI/kg (p<0.05).

CONCLUSIONS

Pts with autonomic neuropathy have a significantly higher prevalence of SIBO, that is also associated with a higher daily insulin requirements.

Authors+Show Affiliations

Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy. veronica.ojetti@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20085122

Citation

Ojetti, V, et al. "Small Bowel Bacterial Overgrowth and Type 1 Diabetes." European Review for Medical and Pharmacological Sciences, vol. 13, no. 6, 2009, pp. 419-23.
Ojetti V, Pitocco D, Scarpellini E, et al. Small bowel bacterial overgrowth and type 1 diabetes. Eur Rev Med Pharmacol Sci. 2009;13(6):419-23.
Ojetti, V., Pitocco, D., Scarpellini, E., Zaccardi, F., Scaldaferri, F., Gigante, G., ... Gasbarrini, A. (2009). Small bowel bacterial overgrowth and type 1 diabetes. European Review for Medical and Pharmacological Sciences, 13(6), pp. 419-23.
Ojetti V, et al. Small Bowel Bacterial Overgrowth and Type 1 Diabetes. Eur Rev Med Pharmacol Sci. 2009;13(6):419-23. PubMed PMID: 20085122.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small bowel bacterial overgrowth and type 1 diabetes. AU - Ojetti,V, AU - Pitocco,D, AU - Scarpellini,E, AU - Zaccardi,F, AU - Scaldaferri,F, AU - Gigante,G, AU - Gasbarrini,G, AU - Ghirlanda,G, AU - Gasbarrini,A, PY - 2010/1/21/entrez PY - 2010/1/21/pubmed PY - 2010/3/2/medline SP - 419 EP - 23 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 13 IS - 6 N2 - BACKGROUND: Gastrointestinal motility disorders are often present in diabetic patients (pts). Such motility dysfunctions have been attributed to autonomic neuropathy. Impaired intestinal motility is often associated with small-bowel bacterial overgrowth (SIBO) but only few studies evaluated the relationship between autonomic neuropathy and SIBO in diabetic pts. AIM: To compare the prevalence of SIBO between type 1 diabetic (T1D) pts with and without autonomic neuropathy. PATIENTS AND METHODS: 25 pts (13 males, 12 females; mean age 44.2+/-7) affected by type 1 diabetes with normal cardiovascular autonomic test (group A) and 25 type 1 diabetic pts with abnormal cardiovascular autonomic test (group B) were submitted to hydrogen lactulose breath test. RESULTS: 2 out of 25 (8%) showed SIBO among group A, while 11 out of 25 (44%) showed SIBO among group B (p<0.01). Interestingly, among group B, the daily insulin requirements was significantly higher in SIBO-positive pts compared to SIBO-negative: 0.66+/-0.3 vs. 0.59+/-0.1 UI/kg (p<0.05). CONCLUSIONS: Pts with autonomic neuropathy have a significantly higher prevalence of SIBO, that is also associated with a higher daily insulin requirements. SN - 1128-3602 UR - https://www.unboundmedicine.com/medline/citation/20085122/Small_bowel_bacterial_overgrowth_and_type_1_diabetes_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -