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HHV-6 IgG4 isotype response following measles infection.
J Med Virol. 2010 Mar; 82(3):396-9.JM

Abstract

Human herpesvirus 6 (HHV-6) is widespread in the human population by infecting most individuals in early childhood. After primary infection, HHV-6 establishes a latent infection by remaining in circulating mononuclear cells of healthy individuals. The HHV-6 antibody titer increases after primary infection with measles virus. The present study was undertaken to determine the specific antiviral IgG1, IgG2, IgG3, and IgG4 subclass response patterns to HHV-6 in HHV-6-seropositive individuals with natural measles virus infection, measles vaccination, and rubella virus infection. The purpose of this study was to examine HHV-6-specific IgG isotype response in patients with acute virus coinfection. Serum samples were obtained from individuals who were seropositive for HHV-6 after natural primary infection with measles virus during an outbreak, measles vaccination, or rubella virus infection, and from healthy individuals. Sera were examined by indirect immunofluorescence assays for detection of HHV-6-specific IgG1, IgG2, IgG3, and IgG4 antibodies. A high percentage (69%) of those infected with measles virus had an HHV-6 IgG1 and IgG4 response (P < 0.001, chi(2) test), whereas persons vaccinated against measles, those infected with rubella, and healthy individuals showed an HHV-6 IgG1 response. These results demonstrate that natural measles virus infection induces an HHV-6 IgG isotype response, which suggests a shift in immune activity from a Th1 to a Th2 response. J. Med. Virol. 82:396-399, 2010. (c) 2010 Wiley-Liss, Inc.

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Authors+Show Affiliations

Ferreyra L
Division of Medical Bacteriology and Virology, School of Medical Sciences, National University of La Rioja, La Rioja, Argentina.
Bustos D
No affiliation info available
Biganzoli P
No affiliation info available
Isa MB
No affiliation info available
Don PS
No affiliation info available
Ribechini E
No affiliation info available
Nates SV
No affiliation info available
Pavan JV
No affiliation info available

MeSH

AdolescentAdultAntibodies, ViralChildChild, PreschoolFluorescent Antibody Technique, IndirectHerpesvirus 6, HumanHumansImmunoglobulin GInfantMeaslesMeasles VaccineMiddle AgedRubellaYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20087929

Citation

Ferreyra, Leonardo, et al. "HHV-6 IgG4 Isotype Response Following Measles Infection." Journal of Medical Virology, vol. 82, no. 3, 2010, pp. 396-9.
Ferreyra L, Bustos D, Biganzoli P, et al. HHV-6 IgG4 isotype response following measles infection. J Med Virol. 2010;82(3):396-9.
Ferreyra, L., Bustos, D., Biganzoli, P., Isa, M. B., Don, P. S., Ribechini, E., Nates, S. V., & Pavan, J. V. (2010). HHV-6 IgG4 isotype response following measles infection. Journal of Medical Virology, 82(3), 396-9. https://doi.org/10.1002/jmv.21702
Ferreyra L, et al. HHV-6 IgG4 Isotype Response Following Measles Infection. J Med Virol. 2010;82(3):396-9. PubMed PMID: 20087929.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HHV-6 IgG4 isotype response following measles infection. AU - Ferreyra,Leonardo, AU - Bustos,Dolores, AU - Biganzoli,Patricia, AU - Isa,Maria Beatriz, AU - Don,Paola Sicilia, AU - Ribechini,Eliana, AU - Nates,Silvia Viviana, AU - Pavan,Jorge Victorio, PY - 2010/1/21/entrez PY - 2010/1/21/pubmed PY - 2010/3/18/medline SP - 396 EP - 9 JF - Journal of medical virology JO - J Med Virol VL - 82 IS - 3 N2 - Human herpesvirus 6 (HHV-6) is widespread in the human population by infecting most individuals in early childhood. After primary infection, HHV-6 establishes a latent infection by remaining in circulating mononuclear cells of healthy individuals. The HHV-6 antibody titer increases after primary infection with measles virus. The present study was undertaken to determine the specific antiviral IgG1, IgG2, IgG3, and IgG4 subclass response patterns to HHV-6 in HHV-6-seropositive individuals with natural measles virus infection, measles vaccination, and rubella virus infection. The purpose of this study was to examine HHV-6-specific IgG isotype response in patients with acute virus coinfection. Serum samples were obtained from individuals who were seropositive for HHV-6 after natural primary infection with measles virus during an outbreak, measles vaccination, or rubella virus infection, and from healthy individuals. Sera were examined by indirect immunofluorescence assays for detection of HHV-6-specific IgG1, IgG2, IgG3, and IgG4 antibodies. A high percentage (69%) of those infected with measles virus had an HHV-6 IgG1 and IgG4 response (P < 0.001, chi(2) test), whereas persons vaccinated against measles, those infected with rubella, and healthy individuals showed an HHV-6 IgG1 response. These results demonstrate that natural measles virus infection induces an HHV-6 IgG isotype response, which suggests a shift in immune activity from a Th1 to a Th2 response. J. Med. Virol. 82:396-399, 2010. (c) 2010 Wiley-Liss, Inc. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/20087929/HHV_6_IgG4_isotype_response_following_measles_infection_ L2 - https://doi.org/10.1002/jmv.21702 DB - PRIME DP - Unbound Medicine ER -