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Benzophenones from Guignardia sp. IFB-E028, an endophyte on Hopea hainanensis.
Chem Biodivers. 2010 Jan; 7(1):216-20.CB

Abstract

The first natural S-containing benzophenone dimer, named guignasulfide (3), was isolated from the culture of Guignardia sp. IFB-E028, an endophytic fungus residing in healthy leaves of Hopea hainanensis. Its structure was determined through correlative analyses of its MS, 1D- and 2D-NMR spectroscopic data. Two other known benzophenone derivatives, monomethylsulochrin and rhizoctonic acid (1 and 2, resp.) were also isolated. Guignasulfide (3) was more active against the human liver cancer cell line HepG2 (IC(50) value: 5.2+/-0.4 microM) than metabolites 1 and 2 (IC(50) values: 63.5+/-0.6 and 60.2+/-0.5 microM); compounds 1-3 showed also moderately inhibitory effects on the human bacterial pathogen Helicobacter pylori with MIC values of 28.9+/-0.1, 60.2+/-0.4, and 42.9+/-0.5 microM, respectively.

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Authors+Show Affiliations

Wang FW
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, Nanjing 210093, P R China.
Ye YH
No affiliation info available
Ding H
No affiliation info available
Chen YX
No affiliation info available
Tan RX
No affiliation info available
Song YC
No affiliation info available

MeSH

Anti-Bacterial AgentsAscomycotaBenzophenonesDipterocarpaceaeHelicobacter pyloriHep G2 CellsHumansSulfides

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20087992

Citation

Wang, Feng-Wu, et al. "Benzophenones From Guignardia Sp. IFB-E028, an Endophyte On Hopea Hainanensis." Chemistry & Biodiversity, vol. 7, no. 1, 2010, pp. 216-20.
Wang FW, Ye YH, Ding H, et al. Benzophenones from Guignardia sp. IFB-E028, an endophyte on Hopea hainanensis. Chem Biodivers. 2010;7(1):216-20.
Wang, F. W., Ye, Y. H., Ding, H., Chen, Y. X., Tan, R. X., & Song, Y. C. (2010). Benzophenones from Guignardia sp. IFB-E028, an endophyte on Hopea hainanensis. Chemistry & Biodiversity, 7(1), 216-20. https://doi.org/10.1002/cbdv.200800353
Wang FW, et al. Benzophenones From Guignardia Sp. IFB-E028, an Endophyte On Hopea Hainanensis. Chem Biodivers. 2010;7(1):216-20. PubMed PMID: 20087992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benzophenones from Guignardia sp. IFB-E028, an endophyte on Hopea hainanensis. AU - Wang,Feng-Wu, AU - Ye,Yong-Hao, AU - Ding,Hui, AU - Chen,Yun-Xi, AU - Tan,Ren-Xiang, AU - Song,Yong-Chun, PY - 2010/1/21/entrez PY - 2010/1/21/pubmed PY - 2010/4/9/medline SP - 216 EP - 20 JF - Chemistry & biodiversity JO - Chem Biodivers VL - 7 IS - 1 N2 - The first natural S-containing benzophenone dimer, named guignasulfide (3), was isolated from the culture of Guignardia sp. IFB-E028, an endophytic fungus residing in healthy leaves of Hopea hainanensis. Its structure was determined through correlative analyses of its MS, 1D- and 2D-NMR spectroscopic data. Two other known benzophenone derivatives, monomethylsulochrin and rhizoctonic acid (1 and 2, resp.) were also isolated. Guignasulfide (3) was more active against the human liver cancer cell line HepG2 (IC(50) value: 5.2+/-0.4 microM) than metabolites 1 and 2 (IC(50) values: 63.5+/-0.6 and 60.2+/-0.5 microM); compounds 1-3 showed also moderately inhibitory effects on the human bacterial pathogen Helicobacter pylori with MIC values of 28.9+/-0.1, 60.2+/-0.4, and 42.9+/-0.5 microM, respectively. SN - 1612-1880 UR - https://www.unboundmedicine.com/medline/citation/20087992/Benzophenones_from_Guignardia_sp__IFB_E028_an_endophyte_on_Hopea_hainanensis_ L2 - https://doi.org/10.1002/cbdv.200800353 DB - PRIME DP - Unbound Medicine ER -