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An iron-based cytosolic catalase and superoxide dismutase mimic complex.
Inorg Chem. 2010 Feb 15; 49(4):1274-6.IC

Abstract

The development of metallodrugs with antioxidant activities is of importance as a way to protect organisms exposed to stressful conditions. Although iron chemistry in the presence of H(2)O(2) is usually associated with pro-oxidant activity, mainly via the Fenton reaction, we found that the mononuclear compound [Fe(HPClNOL)Cl(2)]NO(3) (1; C(15)H(18)Cl(3)FeN(4)O(4), a = 8.7751(3) A, b = 9.0778(4) A, c = 24.3869(10) A, beta = 93.370(2) degrees , monoclinic, P2(1)/c, Z = 4), containing the tripodal ligand 1-[bis(pyridin-2-ylmethyl)amino]-3-chloropropan-2-ol, decomposes hydrogen peroxide and superoxide anion in vitro as well as shows in vivo protection because it prevents the harmful effects promoted by H(2)O(2) on Saccharomyces cerevisiae cells, decreasing the level of lipid peroxidation. This protective effect was observed for wild-type cells, as well as for mutant cells, which do not present the antioxidant metalloenzymes catalase (Ctt1) or copper/zinc superoxide dismutase (Sod1).

Authors+Show Affiliations

Laboratório de Ciências Químicas, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Rio de Janeiro, RJ, Brazil 28013-604. adolfo@uenf.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20088490

Citation

Horn, Adolfo, et al. "An Iron-based Cytosolic Catalase and Superoxide Dismutase Mimic Complex." Inorganic Chemistry, vol. 49, no. 4, 2010, pp. 1274-6.
Horn A, Parrilha GL, Melo KV, et al. An iron-based cytosolic catalase and superoxide dismutase mimic complex. Inorg Chem. 2010;49(4):1274-6.
Horn, A., Parrilha, G. L., Melo, K. V., Fernandes, C., Horner, M., Visentin, L. d. o. . C., Santos, J. A., Santos, M. S., Eleutherio, E. C., & Pereira, M. D. (2010). An iron-based cytosolic catalase and superoxide dismutase mimic complex. Inorganic Chemistry, 49(4), 1274-6. https://doi.org/10.1021/ic901904b
Horn A, et al. An Iron-based Cytosolic Catalase and Superoxide Dismutase Mimic Complex. Inorg Chem. 2010 Feb 15;49(4):1274-6. PubMed PMID: 20088490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An iron-based cytosolic catalase and superoxide dismutase mimic complex. AU - Horn,Adolfo,Jr AU - Parrilha,Gabrieli L, AU - Melo,Karen V, AU - Fernandes,Christiane, AU - Horner,Manfredo, AU - Visentin,Lorenzo do C, AU - Santos,Jullyane A S, AU - Santos,Monique S, AU - Eleutherio,Elis C A, AU - Pereira,Marcos D, PY - 2010/1/22/entrez PY - 2010/1/22/pubmed PY - 2010/5/1/medline SP - 1274 EP - 6 JF - Inorganic chemistry JO - Inorg Chem VL - 49 IS - 4 N2 - The development of metallodrugs with antioxidant activities is of importance as a way to protect organisms exposed to stressful conditions. Although iron chemistry in the presence of H(2)O(2) is usually associated with pro-oxidant activity, mainly via the Fenton reaction, we found that the mononuclear compound [Fe(HPClNOL)Cl(2)]NO(3) (1; C(15)H(18)Cl(3)FeN(4)O(4), a = 8.7751(3) A, b = 9.0778(4) A, c = 24.3869(10) A, beta = 93.370(2) degrees , monoclinic, P2(1)/c, Z = 4), containing the tripodal ligand 1-[bis(pyridin-2-ylmethyl)amino]-3-chloropropan-2-ol, decomposes hydrogen peroxide and superoxide anion in vitro as well as shows in vivo protection because it prevents the harmful effects promoted by H(2)O(2) on Saccharomyces cerevisiae cells, decreasing the level of lipid peroxidation. This protective effect was observed for wild-type cells, as well as for mutant cells, which do not present the antioxidant metalloenzymes catalase (Ctt1) or copper/zinc superoxide dismutase (Sod1). SN - 1520-510X UR - https://www.unboundmedicine.com/medline/citation/20088490/An_iron_based_cytosolic_catalase_and_superoxide_dismutase_mimic_complex_ L2 - https://doi.org/10.1021/ic901904b DB - PRIME DP - Unbound Medicine ER -