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Effects of diets rich in monounsaturated fatty acids on plasma lipoproteins--the Jerusalem Nutrition Study: high MUFAs vs high PUFAs.
Am J Clin Nutr. 1991 Apr; 53(4):899-907.AJ

Abstract

Twenty-six Yeshiva students were randomly assigned to a 24-wk crossover study of monounsaturated fatty acid (MUFA) vs polyunsaturated fatty acid (PUFA) diets (50% carbohydrate, 32% fat, 18% protein) fed alternately during two 12-wk periods. Total plasma cholesterol (TC) decreased significantly by approximately 10% and approximately 16% on the MUFA and PUFA diets, respectively. Plasma triglyceride response was variable. Low-density-lipoprotein cholesterol (LDL-C) decreased in both groups with an additional significant effect between periods. Concentrations of high-density-lipoprotein cholesterol did not change significantly. LDL-receptor status in fresh monocytes, affinity of LDL towards the LDL receptor in cultured fibroblasts, zonal-centrifugation profiles, and lipoprotein composition were not significantly different between the diets. There was a significantly higher tendency toward lipid peroxidation on the PUFA diet, as ascertained by more thiobarbituric acid-reactive-substances formation on that diet. Dietary PUFA results in somewhat lower TC and LDL-C concentrations whereas with MUFA the susceptibility of LDL to oxidative stress is lower.

Authors+Show Affiliations

Department of Medicine B, Hadassah University Hospital, Jerusalem, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2008870

Citation

Berry, E M., et al. "Effects of Diets Rich in Monounsaturated Fatty Acids On Plasma Lipoproteins--the Jerusalem Nutrition Study: High MUFAs Vs High PUFAs." The American Journal of Clinical Nutrition, vol. 53, no. 4, 1991, pp. 899-907.
Berry EM, Eisenberg S, Haratz D, et al. Effects of diets rich in monounsaturated fatty acids on plasma lipoproteins--the Jerusalem Nutrition Study: high MUFAs vs high PUFAs. Am J Clin Nutr. 1991;53(4):899-907.
Berry, E. M., Eisenberg, S., Haratz, D., Friedlander, Y., Norman, Y., Kaufmann, N. A., & Stein, Y. (1991). Effects of diets rich in monounsaturated fatty acids on plasma lipoproteins--the Jerusalem Nutrition Study: high MUFAs vs high PUFAs. The American Journal of Clinical Nutrition, 53(4), 899-907.
Berry EM, et al. Effects of Diets Rich in Monounsaturated Fatty Acids On Plasma Lipoproteins--the Jerusalem Nutrition Study: High MUFAs Vs High PUFAs. Am J Clin Nutr. 1991;53(4):899-907. PubMed PMID: 2008870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of diets rich in monounsaturated fatty acids on plasma lipoproteins--the Jerusalem Nutrition Study: high MUFAs vs high PUFAs. AU - Berry,E M, AU - Eisenberg,S, AU - Haratz,D, AU - Friedlander,Y, AU - Norman,Y, AU - Kaufmann,N A, AU - Stein,Y, PY - 1991/4/1/pubmed PY - 1991/4/1/medline PY - 1991/4/1/entrez SP - 899 EP - 907 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 53 IS - 4 N2 - Twenty-six Yeshiva students were randomly assigned to a 24-wk crossover study of monounsaturated fatty acid (MUFA) vs polyunsaturated fatty acid (PUFA) diets (50% carbohydrate, 32% fat, 18% protein) fed alternately during two 12-wk periods. Total plasma cholesterol (TC) decreased significantly by approximately 10% and approximately 16% on the MUFA and PUFA diets, respectively. Plasma triglyceride response was variable. Low-density-lipoprotein cholesterol (LDL-C) decreased in both groups with an additional significant effect between periods. Concentrations of high-density-lipoprotein cholesterol did not change significantly. LDL-receptor status in fresh monocytes, affinity of LDL towards the LDL receptor in cultured fibroblasts, zonal-centrifugation profiles, and lipoprotein composition were not significantly different between the diets. There was a significantly higher tendency toward lipid peroxidation on the PUFA diet, as ascertained by more thiobarbituric acid-reactive-substances formation on that diet. Dietary PUFA results in somewhat lower TC and LDL-C concentrations whereas with MUFA the susceptibility of LDL to oxidative stress is lower. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/2008870/Effects_of_diets_rich_in_monounsaturated_fatty_acids_on_plasma_lipoproteins__the_Jerusalem_Nutrition_Study:_high_MUFAs_vs_high_PUFAs_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/53.4.899 DB - PRIME DP - Unbound Medicine ER -