Tags

Type your tag names separated by a space and hit enter

Observational study of pregnant women with a previous spontaneous abortion before the 10th gestation week with and without antiphospholipid antibodies.
J Thromb Haemost. 2010 Apr; 8(4):699-706.JT

Abstract

BACKGROUND

A clinical subtype of purely obstetrical antiphospholipid antibody (aPL-Ab) syndrome (APS) requires three or more unexplained consecutive embryonic losses before the 10th week of gestation associated with persistently positive lupus anticoagulant (LAC), and/or anticardiolipin IgG or IgM, and/or anti-beta2-glycoprotein I (abeta2GpI) IgG or IgM. Although this diagnostic classification of APS appeared to be the most sensitive, the APS-associated serological criteria are still debated.

PATIENTS/METHODS

We prospectively observed the second pregnancy of 284 women with a previous embryonic loss, both with and without aPL-Ab.

RESULTS

aPL-Ab-positive women were more prone to pregnancy loss, embryonic loss, pre-eclampsia, placental abruption and intrauterine fetal growth restriction. Type IIa aPL-Ab positivity (LAC present alone) was associated with the highest risk of recurrent embryonic loss and intrauterine growth restriction. Type I aPL-Ab positivity (combinations of aPL-Ab type positivity) was associated with the strongest risks of late complications, pre-eclampsia and placental abruption. Finally, abeta2GpI-M positivities were not clinically relevant in these women.

CONCLUSION

Patients with a first unexplained pregnancy loss before the 10th week of gestation who are also positive for aPL-Abs have a higher risk of various complications in their second pregnancy. In this study, measurement of abeta2GpI-M had a questionable prognostic value.

Authors+Show Affiliations

Research Team EA2992, Montpellier University 1, Nîmes, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20088936

Citation

Chauleur, C, et al. "Observational Study of Pregnant Women With a Previous Spontaneous Abortion Before the 10th Gestation Week With and Without Antiphospholipid Antibodies." Journal of Thrombosis and Haemostasis : JTH, vol. 8, no. 4, 2010, pp. 699-706.
Chauleur C, Galanaud JP, Alonso S, et al. Observational study of pregnant women with a previous spontaneous abortion before the 10th gestation week with and without antiphospholipid antibodies. J Thromb Haemost. 2010;8(4):699-706.
Chauleur, C., Galanaud, J. P., Alonso, S., Cochery-Nouvellon, E., Balducchi, J. P., Marès, P., Fabbro-Peray, P., & Gris, J. C. (2010). Observational study of pregnant women with a previous spontaneous abortion before the 10th gestation week with and without antiphospholipid antibodies. Journal of Thrombosis and Haemostasis : JTH, 8(4), 699-706. https://doi.org/10.1111/j.1538-7836.2010.03747.x
Chauleur C, et al. Observational Study of Pregnant Women With a Previous Spontaneous Abortion Before the 10th Gestation Week With and Without Antiphospholipid Antibodies. J Thromb Haemost. 2010;8(4):699-706. PubMed PMID: 20088936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Observational study of pregnant women with a previous spontaneous abortion before the 10th gestation week with and without antiphospholipid antibodies. AU - Chauleur,C, AU - Galanaud,J-P, AU - Alonso,S, AU - Cochery-Nouvellon,E, AU - Balducchi,J-P, AU - Marès,P, AU - Fabbro-Peray,P, AU - Gris,J-C, Y1 - 2010/01/17/ PY - 2010/1/22/entrez PY - 2010/1/22/pubmed PY - 2010/7/9/medline SP - 699 EP - 706 JF - Journal of thrombosis and haemostasis : JTH JO - J Thromb Haemost VL - 8 IS - 4 N2 - BACKGROUND: A clinical subtype of purely obstetrical antiphospholipid antibody (aPL-Ab) syndrome (APS) requires three or more unexplained consecutive embryonic losses before the 10th week of gestation associated with persistently positive lupus anticoagulant (LAC), and/or anticardiolipin IgG or IgM, and/or anti-beta2-glycoprotein I (abeta2GpI) IgG or IgM. Although this diagnostic classification of APS appeared to be the most sensitive, the APS-associated serological criteria are still debated. PATIENTS/METHODS: We prospectively observed the second pregnancy of 284 women with a previous embryonic loss, both with and without aPL-Ab. RESULTS: aPL-Ab-positive women were more prone to pregnancy loss, embryonic loss, pre-eclampsia, placental abruption and intrauterine fetal growth restriction. Type IIa aPL-Ab positivity (LAC present alone) was associated with the highest risk of recurrent embryonic loss and intrauterine growth restriction. Type I aPL-Ab positivity (combinations of aPL-Ab type positivity) was associated with the strongest risks of late complications, pre-eclampsia and placental abruption. Finally, abeta2GpI-M positivities were not clinically relevant in these women. CONCLUSION: Patients with a first unexplained pregnancy loss before the 10th week of gestation who are also positive for aPL-Abs have a higher risk of various complications in their second pregnancy. In this study, measurement of abeta2GpI-M had a questionable prognostic value. SN - 1538-7836 UR - https://www.unboundmedicine.com/medline/citation/20088936/Observational_study_of_pregnant_women_with_a_previous_spontaneous_abortion_before_the_10th_gestation_week_with_and_without_antiphospholipid_antibodies_ L2 - https://doi.org/10.1111/j.1538-7836.2010.03747.x DB - PRIME DP - Unbound Medicine ER -