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Excessive daytime sleepiness in Parkinson's disease: characteristics and determinants.
Eur Neurol. 2010; 63(3):129-35.EN

Abstract

BACKGROUND/AIMS

Excessive daytime sleepiness (EDS) is frequent in patients with Parkinson's disease (PD). Occasionally, EDS in PD exhibits narcolepsy-like features. We aimed to assess characteristics and determinants of EDS in consecutive patients with PD.

METHODS

Thirty consecutive patients with PD underwent a detailed clinical examination. EDS was assessed using the Epworth Sleepiness Scale (ESS) and Multiple Sleep Latency Test (MSLT). Sleep was assessed using video-polysomnography. Cerebrospinal fluid (CSF) hypocretin-1 levels were obtained in 3 patients.

RESULTS

ESS was >10 in 17 patients (57%). Mean sleep latency (MSL) on MSLT was <5 min in 11 patients (37%). There was a significant negative correlation between ESS and MSL. None of the 11 patients with MSL <5 min showed a sleep onset REM (SOREM) episode. Patients with EDS had higher dopamine agonists/levodopa equivalent doses, higher apnea/hypopnea index and exhibited wearing-off symptoms more often. Hypocretin-1 was normal in 3 patients tested.

CONCLUSION

EDS, which can sometimes be severe, is common in PD patients even in the absence of SOREM and detectable CSF-hypocretin deficiency. In PD, EDS is a multifaceted phenomenon, the determinants of which include severity of PD, wearing-off symptoms, dosage of antiparkinsonian drugs and sleep-disordered breathing.

Authors+Show Affiliations

Department of Neurology, University Hospital Zurich, Zurich, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20090346

Citation

Poryazova, R, et al. "Excessive Daytime Sleepiness in Parkinson's Disease: Characteristics and Determinants." European Neurology, vol. 63, no. 3, 2010, pp. 129-35.
Poryazova R, Benninger D, Waldvogel D, et al. Excessive daytime sleepiness in Parkinson's disease: characteristics and determinants. Eur Neurol. 2010;63(3):129-35.
Poryazova, R., Benninger, D., Waldvogel, D., & Bassetti, C. L. (2010). Excessive daytime sleepiness in Parkinson's disease: characteristics and determinants. European Neurology, 63(3), 129-35. https://doi.org/10.1159/000276402
Poryazova R, et al. Excessive Daytime Sleepiness in Parkinson's Disease: Characteristics and Determinants. Eur Neurol. 2010;63(3):129-35. PubMed PMID: 20090346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Excessive daytime sleepiness in Parkinson's disease: characteristics and determinants. AU - Poryazova,R, AU - Benninger,D, AU - Waldvogel,D, AU - Bassetti,C L, Y1 - 2010/01/16/ PY - 2009/04/22/received PY - 2009/10/18/accepted PY - 2010/1/22/entrez PY - 2010/1/22/pubmed PY - 2010/6/15/medline SP - 129 EP - 35 JF - European neurology JO - Eur Neurol VL - 63 IS - 3 N2 - BACKGROUND/AIMS: Excessive daytime sleepiness (EDS) is frequent in patients with Parkinson's disease (PD). Occasionally, EDS in PD exhibits narcolepsy-like features. We aimed to assess characteristics and determinants of EDS in consecutive patients with PD. METHODS: Thirty consecutive patients with PD underwent a detailed clinical examination. EDS was assessed using the Epworth Sleepiness Scale (ESS) and Multiple Sleep Latency Test (MSLT). Sleep was assessed using video-polysomnography. Cerebrospinal fluid (CSF) hypocretin-1 levels were obtained in 3 patients. RESULTS: ESS was >10 in 17 patients (57%). Mean sleep latency (MSL) on MSLT was <5 min in 11 patients (37%). There was a significant negative correlation between ESS and MSL. None of the 11 patients with MSL <5 min showed a sleep onset REM (SOREM) episode. Patients with EDS had higher dopamine agonists/levodopa equivalent doses, higher apnea/hypopnea index and exhibited wearing-off symptoms more often. Hypocretin-1 was normal in 3 patients tested. CONCLUSION: EDS, which can sometimes be severe, is common in PD patients even in the absence of SOREM and detectable CSF-hypocretin deficiency. In PD, EDS is a multifaceted phenomenon, the determinants of which include severity of PD, wearing-off symptoms, dosage of antiparkinsonian drugs and sleep-disordered breathing. SN - 1421-9913 UR - https://www.unboundmedicine.com/medline/citation/20090346/Excessive_daytime_sleepiness_in_Parkinson's_disease:_characteristics_and_determinants_ L2 - https://www.karger.com?DOI=10.1159/000276402 DB - PRIME DP - Unbound Medicine ER -